Topicort

Skin Diseases, Dermatitis, Allergic Contact, Psoriasis Vulgaris + 1 more
Treatment
20 Active Studies for Topicort

What is Topicort

DesoximetasoneThe Generic name of this drug
Treatment SummaryGlucocorticoid creams are topical anti-inflammatory medications used to treat skin conditions such as dermatitis, skin allergies, and psoriasis.
Desoximetasoneis the brand name
Topicort Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Desoximetasone
Desoximetasone
1985
66

Effectiveness

How Topicort Affects PatientsDesoximetasone is a type of medication that reduces inflammation, itching, and constricts blood vessels when applied to the skin. It is a powerful drug and should not be used with tightly sealed bandages. It should only be used for two weeks at a time and stopped once the desired results are achieved.
How Topicort works in the bodyTopical steroids reduce inflammation, but how they do this is not known for sure. It's thought that they work by changing the way cells make certain molecules that cause inflammation. Steroids bind to receptors in cells and then move inside the cell and bind to DNA, which causes certain genes to be activated or turned off. This then changes the way cells make molecules like prostaglandins and leukotrienes, which are linked to inflammation. The process is thought to start with the drug blocking the release of arachidonic acid from cell membranes, which is needed to make these molecules.

When to interrupt dosage

The suggested dosage of Topicort is contingent upon the specified condition, for instance Atopic Dermatitis, corticosteroid-responsive dermatoses and Psoriasis. The measure can be found in the table below, contingent upon the technique of delivery (e.g. Topical or Cream - Topical).
Condition
Dosage
Administration
Skin Diseases
0.0025 mg/mg, , 0.0005 mg/mg, 2.5 mg/mL, 0.05 %, 0.25 %
Topical, , Ointment, Cream, Cream - Topical, Gel - Topical, Gel, Ointment - Topical, Spray, Emulsion - Topical, Emulsion, Spray - Topical
Psoriasis Vulgaris
0.0025 mg/mg, , 0.0005 mg/mg, 2.5 mg/mL, 0.05 %, 0.25 %
Topical, , Ointment, Cream, Cream - Topical, Gel - Topical, Gel, Ointment - Topical, Spray, Emulsion - Topical, Emulsion, Spray - Topical
Psoriasis
0.0025 mg/mg, , 0.0005 mg/mg, 2.5 mg/mL, 0.05 %, 0.25 %
Topical, , Ointment, Cream, Cream - Topical, Gel - Topical, Gel, Ointment - Topical, Spray, Emulsion - Topical, Emulsion, Spray - Topical
Dermatitis, Allergic Contact
0.0025 mg/mg, , 0.0005 mg/mg, 2.5 mg/mL, 0.05 %, 0.25 %
Topical, , Ointment, Cream, Cream - Topical, Gel - Topical, Gel, Ointment - Topical, Spray, Emulsion - Topical, Emulsion, Spray - Topical

Warnings

There are 20 known major drug interactions with Topicort.
Common Topicort Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Desoximetasone is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Desoximetasone is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abatacept
Major
The risk or severity of adverse effects can be increased when Desoximetasone is combined with Abatacept.
Abetimus
Major
The risk or severity of adverse effects can be increased when Desoximetasone is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Desoximetasone is combined with Acteoside.
Topicort Toxicity & Overdose RiskApplying desoximetasone to the skin may lead to an overdose which can cause thinning of the skin and a weakened ability of the adrenal gland to respond to stress.

Topicort Novel Uses: Which Conditions Have a Clinical Trial Featuring Topicort?

88 active trials are currently examining the potential of Topicort to address Psoriasis, Atopic Dermatitis and Plaque Psoriasis.
Condition
Clinical Trials
Trial Phases
Dermatitis, Allergic Contact
0 Actively Recruiting
Skin Diseases
0 Actively Recruiting
Psoriasis Vulgaris
23 Actively Recruiting
Early Phase 1, Phase 3, Not Applicable, Phase 2, Phase 4, Phase 1
Psoriasis
0 Actively Recruiting

Topicort Reviews: What are patients saying about Topicort?

5Patient Review
4/26/2012
Topicort for Skin Rash that Becomes Thick & Discolored From Rubbing It
I've been using this medication for a while now, but my recent responsibilities as a caregiver have exacerbated my condition. Thankfully, Topicort was able to quickly clear up my skin in just three days. It's dry, so I just use a thin layer of Vaseline to keep it moistened.
5Patient Review
10/18/2008
Topicort for Plaque Psoriasis
I've had psoriasis for most of my life, and Topicort is the only thing that has ever worked well for me. Within two days, my skin was 90% better...and with consistent use, it should stay that way.
5Patient Review
3/9/2010
Topicort for Skin Condition
I had a great experience with this treatment. It cleared up my lichen planis quickly and I haven't had any problems since.
5Patient Review
7/8/2010
Topicort for Reddish Nodules Arranged in a Circle On the Skin
This was the only medicated cream that quickly and effectively cleared up my rash. I've tried other creams before, but they only made the rash worse and it would spread more quickly. If you're dealing with a similar issue, I highly recommend this cream.
5Patient Review
5/28/2011
Topicort for Skin Condition
I was really amazed at how quickly this treatment worked. My skin condition disappeared within just two days!
5Patient Review
6/2/2020
Topicort for Plaque Psoriasis
This medication always gets rid of my psoriasis for a good length of time. I highly recommend it!
4.7Patient Review
12/20/2009
Topicort for Atopic Dermatitis
The cream has effectively treated the redness and scaling on my leg, though I'm not sure what the exact diagnosis is. I've only been using it for a short time so I can't speak to long-term results yet.
4.7Patient Review
3/27/2014
Topicort for Atopic Dermatitis
I developed a rash for no apparent reason and tried several over-the-counter creams to no avail. Finally, I went to the dermatologist who prescribed this medication. It cleared up the rash within just a couple of days - super easy and effective.
4.7Patient Review
1/2/2013
Topicort for Atopic Dermatitis
This treatment quickly got rid of my itchiness and redness. I only had to use it once or twice a day for about a week, which was really convenient.
4Patient Review
5/18/2008
Topicort for Scaly Oily Skin Problem Primarily On Face and Scalp
I had a problem with dry, bumpy acne on my chin. I used this treatment once a day for two weeks and it cleared the problem right up.
3.7Patient Review
7/28/2008
Topicort for Rash
Itching and swelling were both much better within 24 hours. I had a bad case of heat rash, but this treatment really helped.
3.3Patient Review
7/26/2009
Topicort for Rash
I am currently using this product to treat poison ivy, and I was wondering if it would be okay to wear a long sleeve shirt over the treatment.
2.7Patient Review
3/5/2009
Topicort for Reddish Nodules Arranged in a Circle On the Skin
I went back to the dermatologist after a spot developed on my hand. They zapped it with liquid nitrogen, but now it's worse...
2.3Patient Review
4/18/2014
Topicort for Skin Condition
The price is way too expensive for the amount you get.

Patient Q&A Section about topicort

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How long does it take Topicort to work?

"This medication contains a topical anti-inflammatory drug from the cortisone family (corticosteroid). Typically, it is used to treat inflammation and itching. It requires several days for the medication to take effect."

Answered by AI

What are the side effects of desoximetasone?

"The following are symptoms of a reaction to a medication: burning, itching, irritation, redness, or dryness of the skin; tiny red bumps or rash around the mouth; unwanted hair growth; acne; small white or red bumps on the skin; bruising or shiny skin; red or purple blotches or lines under the skin; thin, fragile, or dry skin."

Answered by AI

Is Topicort ointment a steroid?

"Desoximetasone is a steroid medication that is applied to the skin to treat conditions like inflammation and plaque psoriasis."

Answered by AI

What is Topicort used to treat?

"This medication is used to treat conditions such as eczema, dermatitis, allergies, and rash by reducing swelling, itching, and redness. It is a strong corticosteroid."

Answered by AI

Clinical Trials for Topicort

Have you considered Topicort clinical trials? We made a collection of clinical trials featuring Topicort, we think they might fit your search criteria.Go to Trials
Image of Lynderm Research in Markham, Canada.

ESK-001 for Plaque Psoriasis

18+
All Sexes
Markham, Canada
The objective of the ESK-001-018 long term extension is to evaluate the safety and efficacy of ESK-001 over time. The scientific questions it aims to answer are: * How safe is taking ESK-001 long-term in people with moderate to severe plaque psoriasis? * Does taking ESK-001 long-term reduce the severity of people's plaque psoriasis? Patients will enter the long-term extension study following completion of one of the parent studies (ESK-001-016 or ESK-001-017) and will receive open-label ESK-001 twice daily for 24 weeks. After 24 weeks, the first 200 patients meeting at least PASI-75 clinical response will be randomly assigned to receive ESK-001 or placebo. At any point during this time, the patients losing the initial clinical response may return to the open-label ESK-001 treatment. Patients who complete Week 48 will return to open-label ESK-001 treatment and they will receive ESK-001 until the end of the study or discontinuation. All the remaining patients not meeting the entry criteria for the randomized withdrawal phase will continue to receive open-label ESK-001 for the remainder of the study. Patients taking part in the study must be men or women aged at least 18 years old and have completed a previous (parent) study of ESK-001 in moderate to severe plaque psoriasis. Patients must consent and agree to: * ensure drug daily compliance until end of study or discontinuation. * visit the clinic for checkups and assessments. * provide blood and urine samples.
Phase 3
Recruiting
Quick Reply
Lynderm Research (+35 Sites)Alumis Inc
Image of Not posted in Webster, United States.

IRX4204 for Plaque Psoriasis

18+
All Sexes
Webster, TX
The goal of this clinical trial is to learn if IRX4204 works to treat plaque psoriasis in adults. It will also learn about the safety of IRX4204. The main questions it aims to answer are: * Does IRX4204 treat plaque psoriasis symptoms? * Does IRX4204 treat plaque psoriasis symptoms better than someone who is not being treated? * What medical problems do participants have when taking IRX4204? Researchers will compare IRX4204 to a placebo (a look-alike substance that contains no drug) to see if the drug works to treat mild to moderate plaque psoriasis. Participants will: * Take IRX4204 every day for 28 days * Visit the clinic once every week for checkups and tests * Complete specific assessments about plaque psoriasis and changes to plaques
Phase 2
Waitlist Available
Not postedIo Therapeutics
Image of Total Skin and Beauty Dermatology Center, PC in Birmingham, United States.

ESK-001 for Psoriasis

18+
All Sexes
Birmingham, AL
The goal of this clinical trial is to learn if ESK-001 works to treat moderate to severe plaque psoriasis. The main questions it aims to answer are: * Does ESK-001 reduce the severity of people's psoriasis? * How safe is ESK-001 in people with moderate to severe plaque psoriasis? The study includes 2 comparators: a placebo control (a 'dummy' tablet that does not contain the medicine ESK-001 but looks just like it) and an active control (apremilast, which is a medicine approved to treat psoriasis). People taking part in this study must be men or women aged at least 18 years and have had plaque psoriasis for at least 6 months, currently moderate to severe. Participants will: * take drug every day for 24 weeks. * visit the clinic for checkups and tests. * fill out questionnaires about their psoriasis, itch severity, and change in quality of life. * be assessed for health issues and side effects, physical examinations, vital signs, heart electrical activity measurements, and psychological health. * provide blood and urine samples.
Phase 3
Waitlist Available
Total Skin and Beauty Dermatology Center, PC (+58 Sites)Alumis Inc
Have you considered Topicort clinical trials? We made a collection of clinical trials featuring Topicort, we think they might fit your search criteria.Go to Trials
Have you considered Topicort clinical trials? We made a collection of clinical trials featuring Topicort, we think they might fit your search criteria.Go to Trials
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