Pylera

Helicobacter Pylori Infection, Postoperative, Cough + 2 more
Treatment
1 FDA approval
5 Active Studies for Pylera

What is Pylera

Bismuth subcitrate potassiumThe Generic name of this drug
Treatment SummaryA bismuth compound is a medication used to treat peptic ulcers and gastroesophageal reflux disease (GORD).
Pylerais the brand name
Pylera Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Pylera
Bismuth subcitrate potassium
2007
4

Approved as Treatment by the FDA

Bismuth subcitrate potassium, also known as Pylera, is approved by the FDA for 1 uses which include Helicobacter Pylori Infection .
Helicobacter Pylori Infection
Used to treat Helicobacter Pylori Infection in combination with Metronidazole

Effectiveness

How Pylera Affects PatientsBismuth subcitrate is an effective treatment for stomach and intestine issues. It does not reduce acid levels or affect how much acid is produced.
How Pylera works in the bodyColloidal bismuth subcitrate works in multiple ways to treat gastroduodenal disorders. It does not affect acid production, but it does block the action of peptic acid. It also causes an increase in mucus glycoprotein and can form a barrier to protect the stomach from acid. It helps heal ulcers, increases mucosal secretion of protective substances, and kills bacteria associated with gastritis and ulcers. Additionally, it prevents bacteria from sticking to the lining of the stomach and inhibits the enzymes they produce.

When to interrupt dosage

The proffered dosage of Pylera is contingent upon the diagnosed state, such as Postoperative, Bronchoscopy and Stomach Ulcer. The amount of dosage can be found in the table below, contingent upon the technique of delivery.
Condition
Dosage
Administration
Postoperative
, 140.0 mg, 40.0 mg
Oral, , Capsule, Capsule - Oral
Preoperative
, 140.0 mg, 40.0 mg
Oral, , Capsule, Capsule - Oral
Cough
, 140.0 mg, 40.0 mg
Oral, , Capsule, Capsule - Oral
Bronchoscopy
, 140.0 mg, 40.0 mg
Oral, , Capsule, Capsule - Oral
Helicobacter Pylori Infection
, 140.0 mg, 40.0 mg
Oral, , Capsule, Capsule - Oral

Warnings

Pylera has three contraindications, so it should not be utilized in conjunction with the conditions documented in the table below.Pylera Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
ethanol
Do Not Combine
There are 20 known major drug interactions with Pylera.
Common Pylera Drug Interactions
Drug Name
Risk Level
Description
Bismuth subcarbonate
Major
Bismuth subcitrate potassium may increase the neurotoxic activities of Bismuth subcarbonate.
Bismuth subgallate
Major
Bismuth subcitrate potassium may increase the neurotoxic activities of Bismuth subgallate.
Bismuth subnitrate
Major
Bismuth subcitrate potassium may increase the neurotoxic activities of Bismuth subnitrate.
Valproate bismuth
Major
Bismuth subcitrate potassium may increase the neurotoxic activities of Valproate bismuth.
Amitriptylinoxide
Minor
Bismuth subcitrate potassium may increase the neurotoxic activities of Amitriptylinoxide.
image of a doctor in a lab doing drug, clinical research

Pylera Novel Uses: Which Conditions Have a Clinical Trial Featuring Pylera?

One ongoing clinical trial is examining the effectiveness of Pylera in relieving Cough, Acute Bronchoscopy and Stomach Ulcer symptoms.
Condition
Clinical Trials
Trial Phases
Postoperative
3 Actively Recruiting
Not Applicable, Early Phase 1
Bronchoscopy
0 Actively Recruiting
Helicobacter Pylori Infection
2 Actively Recruiting
Not Applicable, Phase 4
Cough
0 Actively Recruiting
Preoperative
0 Actively Recruiting

Pylera Reviews: What are patients saying about Pylera?

4.7Patient Review
5/18/2021
Pylera for Inflammation of the Stomach Lining caused by H. Pylori
This medicine has been incredibly effective at treating my H. pylori infection. I started feeling better very quickly after starting the course, and didn't experience any of the reported side effects like black stools (although some stool discoloration is to be expected). Overall, this was a tricky medication to schedule due to its high frequency dosing requirements, but once I figured out a workable routine it was no problem. I would definitely take this medication again if necessary.
3.7Patient Review
4/15/2022
Pylera for Inflammation of the Stomach Lining caused by H. Pylori
I'm on day 8 and have experienced a few side effects: black tongue, stool, tiredness and little weight loss. I've been eating bananas every dose and drinking one bottle of synergy raw Kombucha daily for probiotics. I'm feeling ok better than before the meds for sure. Hope my story helps!
3.7Patient Review
4/13/2018
Pylera for Ulcer of Duodenum caused by Bacteria Helicobacter Pylori
The only side effect I experienced was soft, dark green stool.
3.3Patient Review
8/22/2022
Pylera for Inflammation of the Stomach Lining caused by H. Pylori
Although the initial test results were positive, I am now HP negative (4 months later). I had an endoscopy and another AG tool test to confirm. Still experience mild bloating and discomfort if I eat a tad too much, but otherwise this medication was effective for me.
2.7Patient Review
5/14/2021
Pylera for Ulcer of Duodenum caused by Bacteria Helicobacter Pylori
This treatment is tough, but it's worth it. I had ten days of h. pylori treatment. The first three were fine, but the last seven were rough. I had a terrible taste in my mouth, was tired all the time, nauseous, and had green stools and a stomach ache. On top of that, I had mild panic attacks. But as soon as I stopped taking the pills, all those symptoms faded away within 48 hours. So hang in there and take the pills correctly and it'll be over before you know it.
2.7Patient Review
4/4/2022
Pylera for Inflammation of the Stomach Lining caused by H. Pylori
I followed the instructions to a tee but unfortunately saw no results. I ended up having to self-medicate with azithromycin, which seemed to be much more effective in clearing the infection.
2.7Patient Review
3/29/2019
Pylera for Inflammation of the Stomach Lining caused by H. Pylori
I'm on my third day of the medication and I'm already struggling. I still have 11 days to go. I constantly feel nauseous, dizzy, and weak. I really hope it's worth it in the end.
2.3Patient Review
8/28/2022
Pylera for Ulcer of Duodenum caused by Bacteria Helicobacter Pylori
I am on day 7 and I can say with certainty that this is the worst medication I have ever taken. On the third day, I had hallucinations so bad that I thought I was going to faint. In addition to feeling tired and restless, I also can't concentrate or work properly. Hopefully the next three days go by quickly.
2Patient Review
5/4/2019
Pylera for Inflammation of the Stomach Lining caused by H. Pylori
I'm on day six of the treatment, and I have been experiencing a lot of pain in my stomach. It's hard to eat, I'm always tired, and it hurts to pass stool because of the pain. I hope I don't have to go through another round of this because it's worse than the pain I was feeling beforehand!
1.7Patient Review
4/16/2020
Pylera for Ulcer of Duodenum caused by Bacteria Helicobacter Pylori
The doctor told me to take this medication three times a day for two weeks. Is that the correct amount?
1.3Patient Review
10/31/2018
Pylera for Inflammation of the Stomach Lining caused by H. Pylori
The high cost of this drug really prevents me from being able to recommend it to others. $1,500 is way too much for most people.
1.3Patient Review
10/27/2021
Pylera for Inflammation of the Stomach Lining caused by H. Pylori
I was only prescribed this for 30 days, but I started having negative side effects after just 9 days. My tooth became sensitive and I had a stinging pain in my stomach. I'm worried that this might have caused me to get ulcers, so I stopped taking it immediately and will be discussing it with my doctor at my next appointment.
1Patient Review
7/15/2018
Pylera for Ulcer of Duodenum caused by Bacteria Helicobacter Pylori
I am currently on day three of the treatment, and I have had several troubling side effects. These include migraines, nausea, black stool, and dark urine. I will be contacting my doctor tomorrow to discuss whether or not I should continue with the treatment.

Patient Q&A Section about pylera

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Pylera an antibiotic?

"Pylera is a combination of a mineral and two antibiotics that is used to treat stomach ulcers associated with H pylori infection."

Answered by AI

When should I take Pylera?

"You should take Pylera after meals and at bedtime. If you are also taking omeprazole, take it after your morning and evening meals. Even if your symptoms improve quickly, you should continue using this medicine. If you skip doses, the infection could become resistant to the medication."

Answered by AI

How long does it take for Pylera to work?

"Side effects are typically minimal.

This therapy takes only ten days to complete, which is shorter than other options. It is a good choice for those who cannot take macrolides, which are a class of antibiotics used to treat H. pylori. Side effects from this therapy are usually minimal."

Answered by AI

What is Pylera used for?

"This drug is used in conjunction with an acid blocker, such as a proton pump inhibitor, to treat stomach or intestinal ulcers caused by the bacteria H. pylori. It is also effective in preventing the ulcers from returning."

Answered by AI

Clinical Trials for Pylera

Image of University of Virginia in Charlottesville, United States.

Methadone vs Remifentanil for Pain in Craniotomy Surgery

18 - 65
All Sexes
Charlottesville, VA
Postoperative pain is prevalent after intracranial surgery. Patients undergoing craniotomy are typically managed with short acting opioids to enable early and reliable post-operative neurological exam as well as avoid the risk of respiratory depression. However, a plethora of studies have shown that a majority of these patients experience moderate to severe pain in first 48 hours after surgery. Suboptimal pain control can lead to complications such as arterial hypertension and post-operative intracranial hemorrhage, and hence, increased morbidity and mortality. Intravenous (IV) methadone has a long analgesic half-life and has N-methyl-D-aspartate (NMDA) receptor antagonist and serotonin and norepinephrine reuptake inhibitor (SNRI) properties. It has previously been shown to reduce postoperative opioid requirements, postoperative nausea and vomiting (PONV), and postoperative pain scores in patients that underwent orthopedic, abdominal, complex spine, and cardiac surgery. Similar findings have been shown in obstetric patients that underwent caesarean delivery under general anesthesia as well as patients that underwent gynecologic surgery and received IV methadone intraoperatively. In a recently published retrospective study, a single intraoperative dose of IV methadone was well tolerated with lower pain scores as well as MME (oral morphine milligram equivalents) requirements for up to 72 hours after elective intracranial surgery. IV methadone has, however, never been compared with conventional management via IV remifentanil for functional recovery in patients undergoing elective intercranial surgery. The investigator's hypothesis is that intravenous (IV) methadone is non-inferior to IV remifentanil in patients who undergo elective intracranial surgery. It offers the advantage of being a single dose noninvasive analgesic modality that may contribute to decreasing MME consumption during the first 72 hours postoperatively, controlling postoperative pain, and improving quality of recovery after surgery.
Phase < 1
Waitlist Available
University of Virginia
Image of Brigham and Women's Hospital in Boston, United States.

Argon Plasma for Helicobacter Pylori Infection

18+
All Sexes
Boston, MA
The objective of the study is to investigate the efficacy and safety of an argon plasma-based therapy - HEAPE - in treating H. pylori infections during endoscopic procedures. By filling the stomach with sodium chloride solution that is treated with APC (PAL), the Investigators hypothesize a significant reduction in H. pylori. The use of PAL instead of direct application of APC allows for a broader and more homogeneous application throughout the stomach and a faster procedure time, as the fluid bypasses the thermal effects typically associated with higher electrical power settings and focuses on the bactericidal action of PAL. It is a procedure that does not involve thermal ablation of the stomach lining. Thus, side effects should be expected to be as low as possible. Two different PAL generation modalities will be compared in this study: 1. HEAPE direct: This modality is the direct generation of PAL in the stomach. The stomach is filled with sodium chloride solution which is then treated with APC. With HEAPE direct a potential decrease of reactive species is avoided, as the treatment happens directly at the intended location in the H. pylori infected stomach. 2. Pre-HEAPE: This modality features the treatment of sodium chloride with APC outside of the patient in a sterile container. After the APC treatment, the generated PAL is administered into the stomach with a syringe through the working channel of the endoscope. Pre-HEAPE allows an easier handling of the APC probe as the treatment of the sodium chloride solution can be done without an endoscope. To evaluate the immediate effect of this novel treatment approach the metabolic activity of H. pylori will be assessed using a urea breath test (UBT) before and after treatment. A reduction in H. pylori levels can be detected by a reduction in urease activity in the breath test. After the HEAPE procedure, patients are treated with antibiotics (best practice) as they would be under normal circumstances. Four weeks after treatment, another UBT is performed to determine if H. pylori has been eradicated or if additional antibiotic treatment is indicated. This two-arm, randomized, pilot, single-center, prospective clinical study is designed to evaluate the safety, tolerability and proof of concept that PAL has the ability to eradicate or reduce the bacterial load of H. pylori in humans.
Recruiting
Has No Placebo
Brigham and Women's HospitalChristopher C Thompson, MDErbe Elektromedizin GmbH
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