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What is Pylera
Bismuth subcitrate potassiumThe Generic name of this drug
Treatment SummaryA bismuth compound is a medication used to treat peptic ulcers and gastroesophageal reflux disease (GORD).
Pylerais the brand name
Pylera Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Pylera
Bismuth subcitrate potassium
2007
4
Approved as Treatment by the FDA
Bismuth subcitrate potassium, also known as Pylera, is approved by the FDA for 1 uses which include Helicobacter Pylori Infection .Helicobacter Pylori Infection
Used to treat Helicobacter Pylori Infection in combination with Metronidazole
Effectiveness
How Pylera Affects PatientsBismuth subcitrate is an effective treatment for stomach and intestine issues. It does not reduce acid levels or affect how much acid is produced.
How Pylera works in the bodyColloidal bismuth subcitrate works in multiple ways to treat gastroduodenal disorders. It does not affect acid production, but it does block the action of peptic acid. It also causes an increase in mucus glycoprotein and can form a barrier to protect the stomach from acid. It helps heal ulcers, increases mucosal secretion of protective substances, and kills bacteria associated with gastritis and ulcers. Additionally, it prevents bacteria from sticking to the lining of the stomach and inhibits the enzymes they produce.
When to interrupt dosage
The proffered dosage of Pylera is contingent upon the diagnosed state, such as Postoperative, Bronchoscopy and Stomach Ulcer. The amount of dosage can be found in the table below, contingent upon the technique of delivery.Condition
Dosage
Administration
Postoperative
, 140.0 mg, 40.0 mg
Oral, , Capsule, Capsule - Oral
Bronchoscopy
, 140.0 mg, 40.0 mg
Oral, , Capsule, Capsule - Oral
Preoperative
, 140.0 mg, 40.0 mg
Oral, , Capsule, Capsule - Oral
Helicobacter Pylori Infection
, 140.0 mg, 40.0 mg
Oral, , Capsule, Capsule - Oral
Cough, Acute
, 140.0 mg, 40.0 mg
Oral, , Capsule, Capsule - Oral
Warnings
Pylera has three contraindications, so it should not be utilized in conjunction with the conditions documented in the table below.Pylera ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
ethanol
Do Not Combine
Common Pylera Drug Interactions
Drug Name
Risk Level
Description
Bismuth subcarbonate
Major
Bismuth subcitrate potassium may increase the neurotoxic activities of Bismuth subcarbonate.
Bismuth subgallate
Major
Bismuth subcitrate potassium may increase the neurotoxic activities of Bismuth subgallate.
Bismuth subnitrate
Major
Bismuth subcitrate potassium may increase the neurotoxic activities of Bismuth subnitrate.
Valproate bismuth
Major
Bismuth subcitrate potassium may increase the neurotoxic activities of Valproate bismuth.
Amitriptylinoxide
Minor
Bismuth subcitrate potassium may increase the neurotoxic activities of Amitriptylinoxide.
Pylera Novel Uses: Which Conditions Have a Clinical Trial Featuring Pylera?
One ongoing clinical trial is examining the effectiveness of Pylera in relieving Cough, Acute Bronchoscopy and Stomach Ulcer symptoms.Condition
Clinical Trials
Trial Phases
Helicobacter Pylori Infection
0 Actively Recruiting
Postoperative
1 Actively Recruiting
Not Applicable
Cough, Acute
0 Actively Recruiting
Bronchoscopy
0 Actively Recruiting
Preoperative
0 Actively Recruiting
Pylera Reviews: What are patients saying about Pylera?
4.7Patient Review
5/18/2021 This medicine has been incredibly effective at treating my H. pylori infection. I started feeling better very quickly after starting the course, and didn't experience any of the reported side effects like black stools (although some stool discoloration is to be expected). Overall, this was a tricky medication to schedule due to its high frequency dosing requirements, but once I figured out a workable routine it was no problem. I would definitely take this medication again if necessary.
3.7Patient Review
4/15/2022 I'm on day 8 and have experienced a few side effects: black tongue, stool, tiredness and little weight loss. I've been eating bananas every dose and drinking one bottle of synergy raw Kombucha daily for probiotics. I'm feeling ok better than before the meds for sure. Hope my story helps!
3.7Patient Review
4/13/2018 The only side effect I experienced was soft, dark green stool.
3.3Patient Review
8/22/2022 Although the initial test results were positive, I am now HP negative (4 months later). I had an endoscopy and another AG tool test to confirm. Still experience mild bloating and discomfort if I eat a tad too much, but otherwise this medication was effective for me.
2.7Patient Review
5/14/2021 This treatment is tough, but it's worth it. I had ten days of h. pylori treatment. The first three were fine, but the last seven were rough. I had a terrible taste in my mouth, was tired all the time, nauseous, and had green stools and a stomach ache. On top of that, I had mild panic attacks. But as soon as I stopped taking the pills, all those symptoms faded away within 48 hours. So hang in there and take the pills correctly and it'll be over before you know it.
2.7Patient Review
4/4/2022 I followed the instructions to a tee but unfortunately saw no results. I ended up having to self-medicate with azithromycin, which seemed to be much more effective in clearing the infection.
2.7Patient Review
3/29/2019 I'm on my third day of the medication and I'm already struggling. I still have 11 days to go. I constantly feel nauseous, dizzy, and weak. I really hope it's worth it in the end.
2.3Patient Review
8/28/2022 I am on day 7 and I can say with certainty that this is the worst medication I have ever taken. On the third day, I had hallucinations so bad that I thought I was going to faint. In addition to feeling tired and restless, I also can't concentrate or work properly. Hopefully the next three days go by quickly.
2Patient Review
5/4/2019 I'm on day six of the treatment, and I have been experiencing a lot of pain in my stomach. It's hard to eat, I'm always tired, and it hurts to pass stool because of the pain. I hope I don't have to go through another round of this because it's worse than the pain I was feeling beforehand!
1.7Patient Review
4/16/2020 The doctor told me to take this medication three times a day for two weeks. Is that the correct amount?
1.3Patient Review
10/31/2018 The high cost of this drug really prevents me from being able to recommend it to others. $1,500 is way too much for most people.
1.3Patient Review
10/27/2021 I was only prescribed this for 30 days, but I started having negative side effects after just 9 days. My tooth became sensitive and I had a stinging pain in my stomach. I'm worried that this might have caused me to get ulcers, so I stopped taking it immediately and will be discussing it with my doctor at my next appointment.
1Patient Review
7/15/2018 I am currently on day three of the treatment, and I have had several troubling side effects. These include migraines, nausea, black stool, and dark urine. I will be contacting my doctor tomorrow to discuss whether or not I should continue with the treatment.
Patient Q&A Section about pylera
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Pylera an antibiotic?
"Pylera is a combination of a mineral and two antibiotics that is used to treat stomach ulcers associated with H pylori infection."
Answered by AI
When should I take Pylera?
"You should take Pylera after meals and at bedtime. If you are also taking omeprazole, take it after your morning and evening meals. Even if your symptoms improve quickly, you should continue using this medicine. If you skip doses, the infection could become resistant to the medication."
Answered by AI
How long does it take for Pylera to work?
"Side effects are typically minimal.
This therapy takes only ten days to complete, which is shorter than other options. It is a good choice for those who cannot take macrolides, which are a class of antibiotics used to treat H. pylori. Side effects from this therapy are usually minimal."
Answered by AI
What is Pylera used for?
"This drug is used in conjunction with an acid blocker, such as a proton pump inhibitor, to treat stomach or intestinal ulcers caused by the bacteria H. pylori. It is also effective in preventing the ulcers from returning."
Answered by AI