Doxycycline for Acne
Trial Summary
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you've taken certain antibiotics, isotretinoin, or oral probiotics recently. Also, you can't be using proton pump inhibitors or have changed your oral contraceptive brand within four weeks of starting the study.
What data supports the effectiveness of the drug Doxycycline for treating acne?
Research shows that Doxycycline, especially in low doses, is effective in reducing acne lesions. In one study, 11 out of 12 participants had a 50% reduction in acne lesions after eight weeks of treatment with Doxycycline hyclate. Another study found that a combination of Doxycycline with other topical treatments significantly improved severe acne in most patients by week 12.12345
Is doxycycline safe for treating acne?
Doxycycline is generally considered safe for treating acne, but it can cause side effects like stomach issues, sensitivity to sunlight, and, rarely, severe allergic reactions. It is usually safer than minocycline, another acne treatment, but there have been rare cases of serious hypersensitivity reactions.16789
How is the drug doxycycline unique in treating acne?
What is the purpose of this trial?
Lipidome and microbiome analysis in subjects with acne on doxycycline. Investigators will look at the skin lipidome, blood lipidome, gut micro biome and skin micro biome.Investigators will look at the changes between acne subjects and control participants, but also the changes that occur after the use of antibiotics and how this is altered.
Research Team
Raja K Sivamani, MD MS CAT
Principal Investigator
UCDavis
Eligibility Criteria
This trial is for individuals aged 15 and older who have acne diagnosed by a dermatologist and are prescribed or eligible for Doxycycline. They must understand the study procedures and consent forms. Excluded are those with certain chronic diseases, recent antibiotic use, allergies to tetracyclines, high BMI, or on specific medications.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive doxycycline and undergo assessment of gut, blood, and skin microbiomes and lipidomes
Follow-up
Participants are monitored for changes in microbiome and lipidome profiles after treatment
Treatment Details
Interventions
- Doxycycline
Doxycycline is already approved in United States, European Union, Canada, Japan for the following indications:
- Acne
- Bacterial infections
- Chlamydia
- Gonorrhea
- Lyme disease
- Malaria
- Pneumonia
- Rosacea
- Urinary tract infections
- Acne
- Bacterial infections
- Chlamydia
- Gonorrhea
- Lyme disease
- Malaria
- Pneumonia
- Rosacea
- Urinary tract infections
- Acne
- Bacterial infections
- Chlamydia
- Gonorrhea
- Lyme disease
- Malaria
- Pneumonia
- Rosacea
- Urinary tract infections
- Acne
- Bacterial infections
- Chlamydia
- Gonorrhea
- Lyme disease
- Malaria
- Pneumonia
- Rosacea
- Urinary tract infections
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, Davis
Lead Sponsor