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Cyclophosphamide + Sirolimus for Advanced Thyroid Cancer
Study Summary
This trial will study the effects of two drugs, Cyclophosphamide and Sirolimus, on thyroid cancer that has spread.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
Media Library
- People who are in jail or prison.I do not have any serious health issues or infections that would stop me from receiving the study treatment.I am allergic to cyclophosphamide or sirolimus.I have a blockage in my urinary tract.I am mentally capable of understanding and following the study's requirements.I haven't had chemotherapy, radiation, or tyrosine kinase inhibitor treatments in the last 4 weeks.I have been treated with an mTOR inhibitor before.I haven't had advanced genetic testing on my cancer.I am not on strong CYP3A4 or P-glycoprotein inhibitors/inducers, or can stop them a week before starting Cyclophosphamide and Sirolimus.My stomach or intestines do not work well, affecting how I absorb medicine.I am not using, or unable to use, birth control or practice abstinence.I am not pregnant or breast-feeding.My thyroid cancer cannot be cured by surgery or I have chosen not to undergo curative treatment.My cancer has grown despite treatment, and I have a tumor larger than 10 mm.My organs and bone marrow are working well.I am willing and able to follow the study's schedule and procedures.I am able to get out of my bed or chair and move around.You are expected to live for at least 12 more weeks.Iodine-131 treatment did not work for me or I can't receive it.I have not had 131I therapy in the last 6 months, or 1 month if my post-treatment scan was negative.I haven't had 131I therapy in the last 6 months, or 4 weeks if my post-treatment scan was negative.I am 18 years old or older.
- Group 1: Cyclophosphamide and Sirolimus
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What studies have been done on the long-term effects of Sirolimus?
"Sirolimus has received a score of 2 from our team at Power. This is because, although there is data supporting its safety, this medication has not yet been proven effective in clinical trials."
What is the total subject pool for this experiment?
"According to the clinicaltrials.gov website, this clinical trial is still looking for patients. This particular study was first posted on April 27th, 2017 and received its most recent update on August 15th, 2022. So far, 19 patients have been enrolled at 1 site."
For what purpose is Sirolimus most often prescribed?
"Sirolimus is a medication that's frequently used in organ transplantation procedures. Additionally, it has shown to be helpful for patients with multiple sclerosis, leukemia, myelocytic, acute conditions, and retinoblastoma."
Are new participants being accepted for this experiment?
"The online registry, clinicaltrials.gov, shows that this trial is open and looking for patients. This particular study was first advertised on April 27th, 2017 with the most recent update being from August 15th, 2022."
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