← Back to Search

Morphine for Blood Cancers

Phase < 1
Waitlist Available
Led By Akhila S Reddy
Research Sponsored by M.D. Anderson Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Diagnosis of cancer related pain currently treated with first line strong oral opioid analgesics such as morphine, oxycodone, oxymorphone, hydromorphone or hydrocodone
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 10 or any day after 2 days of rotation to levorphanol
Awards & highlights

Study Summary

This trial is testing whether levorphanol can help reduce pain in cancer patients who have tried other opioids.

Eligible Conditions
  • Blood Cancers
  • Cancer

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
You are currently taking strong pain medication like morphine or oxycodone for cancer-related pain.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline up to day 10 or any day after 2 days of rotation to levorphanol
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline up to day 10 or any day after 2 days of rotation to levorphanol for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Proportion of successful opioid rotation (OR) from morphine equivalent daily dose (MEDD) to levorphanol
Secondary outcome measures
Change of Edmonton Symptom Assessment Scale (ESAS) pain score
Incidence of levorphanol related side effects
Opioid rotation ratio (ORR)
+1 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: Supportive care (levorphanol, opioid regimen)Experimental Treatment7 Interventions
Patients receive levorphanol PO every 8 or 12 hours for 30 days. Patients may receive opioid regimen including hydrocodone, morphine, hydromorphone, oxycodone, and oxymorphone for breakthrough pain. Patients may continue levorphanol for an additional 6-8 months if it is determined by the Principal Investigator the patient can continue.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Oxycodone
2014
Completed Phase 4
~2210
Oxymorphone
2016
Completed Phase 1
~27190
Morphine
2013
Completed Phase 4
~2230
Hydrocodone
2016
Completed Phase 4
~27640
Hydromorphone
2005
Completed Phase 4
~4340
Levorphanol
2018
Completed Early Phase 1
~50

Find a Location

Who is running the clinical trial?

M.D. Anderson Cancer CenterLead Sponsor
2,958 Previous Clinical Trials
1,798,309 Total Patients Enrolled
National Cancer Institute (NCI)NIH
13,607 Previous Clinical Trials
40,913,941 Total Patients Enrolled
1 Trials studying Blood Cancers
70 Patients Enrolled for Blood Cancers
Akhila S ReddyPrincipal InvestigatorM.D. Anderson Cancer Center
1 Previous Clinical Trials
400 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this study the inaugural research of its type?

"Currently, 123 trials assessing the medical efficacy of Morphine are being conducted in 311 cities and 36 countries. The initial investigation into this drug was sponsored by Merck Sharp & Dohme LLC in 2005 with 80 participants involved up until Phase 4 approval. Since then, 1295 separate studies have been completed."

Answered by AI

Can you provide a synopsis of other experiments conducted involving Morphine?

"At present, 123 ongoing clinical trials for Morphine are underway with 29 in their third phase. Although the majority of these studies are taking place in Boston, Massachusetts, there exists a total of 652 sites conducting research on this medication."

Answered by AI

What therapeutic objectives is Morphine typically employed to address?

"Morphine can be employed to address peripheral vascular disease, neuropathic pain, and other medical procedures."

Answered by AI

How many individuals have been recruited for this clinical trial thus far?

"This medical trial is not actively accepting participants at the moment. It was first posted on November 29th 2018 and last updated June 29 2022. If you are seeking other studies, there are 2436 clinical trials recruiting patients with lymphoid cells and 123 trials for Morphine currently enrolling volunteers."

Answered by AI

Are there still opportunities for individuals to join this testing program?

"This research is no longer in need of participants. It was first posted on November 29th 2018, and last edited on June 29 2022. For individuals searching for alternate trials, 2436 studies recruiting lymphoid cells are currently enrolling candidates, while 123 separate Morphine related clinical studies remain active."

Answered by AI
~7 spots leftby Mar 2025