Epidural Steroids for Slipped Disc
(Intra-Op Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this study is to determine a grading system for inflammation in lumbar disc herniation and which groups, if any, benefit most from the administration of an intra-operative epidural steroid.
Will I have to stop taking my current medications?
The trial protocol does not specify whether you need to stop taking your current medications. However, if you are using chronic steroids or immunosuppressive drugs, you may not be eligible to participate.
Is dexamethasone safe for treating slipped discs?
How does the drug used in the trial for slipped disc differ from other treatments?
Epidural steroids, like dexamethasone, are injected directly into the space around the spinal nerves, which can provide quick pain relief by reducing inflammation. This method is different from oral medications or surgery, as it targets the affected area directly and may help avoid surgery in many cases.26789
What evidence supports the effectiveness of the drug dexamethasone for treating a slipped disc?
Who Is on the Research Team?
Don Kim Moore, MD
Principal Investigator
Missouri Orthopaedic Institute
Are You a Good Fit for This Trial?
This trial is for individuals with a confirmed single-level lumbar disc herniation, experiencing leg pain or nerve-related symptoms, who haven't improved with rest, anti-inflammatory meds, or physical therapy. It's only for those treated within the University of Missouri hospital system and not for pregnant women, people with certain spine conditions like spinal stenosis or previous surgery at the affected level.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo discectomy surgery with intraoperative administration of either dexamethasone or placebo
Follow-up
Participants are monitored for post-operative outcomes including disability index, pain scores, opioid usage, and complications
What Are the Treatments Tested in This Trial?
Interventions
- Dexamethasone
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Missouri-Columbia
Lead Sponsor