Laser Treatments for Glaucoma

Age: 18+

Sex: Any

Trial Phase: Phase 4

Sponsor: Medical University of South Carolina

Disqualifiers: Angle-closure glaucoma, Recent ocular surgery, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Prior Safety Data This treatment has passed at least one previous human trial

Compensation: Varies

Number of Visits: 1

Duration: 1 day

What You Need to Know Before You Apply

What is the purpose of this trial?

This study compares two FDA-approved laser treatments for glaucoma: Direct Selective Laser Trabeculoplasty (DSLT) and Selective Laser Trabeculoplasty (SLT). Both procedures aim to lower eye pressure and prevent vision loss. DSLT is a newer, non-contact technique that may improve comfort and efficiency. Participants will be randomly assigned to receive either DSLT or SLT and followed for 12 months to assess eye pressure, safety, and treatment outcomes.

Who Is on the Research Team?

Jella An, MD

Principal Investigator

Medical University of South Carolina

Are You a Good Fit for This Trial?

This trial is for adults over 18 with Open-Angle Glaucoma (OAG) or Ocular Hypertension (OHT), who have a clear view of the eye's drainage angle. Participants must be able to consent and attend follow-up appointments.

Inclusion Criteria

Gonioscopically open angle (visible scleral spur 360°)

I am 18 years old or older.

I have been diagnosed with open-angle glaucoma or high eye pressure.

Exclusion Criteria

IOP >35 mmHg despite therapy

I have had eye surgery in the last 6 months.

I have an eye condition that affects laser treatments or pressure tests.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive either Direct Selective Laser Trabeculoplasty (DSLT) or Selective Laser Trabeculoplasty (SLT) to lower eye pressure

1 day

1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

12 months

Regular visits as per study protocol

What Are the Treatments Tested in This Trial?

Interventions

• Direct Selective laser Trabeculoplasty

Trial Overview

The study compares two FDA-approved laser treatments for glaucoma: Direct Selective Laser Trabeculoplasty (DSLT) and standard Selective Laser Trabeculoplasty (SLT). It aims to see if DSLT is as good as SLT in lowering eye pressure over a year.

How Is the Trial Designed?

Group I: Direct Selective Laser Trabeculoplasty Experimental Treatment 1 Intervention

This arm is going to receive the Direct SLT treatment

Group II: Traditional Selective Laser Trabeculoplasty Active Control 1 Intervention

This arm is going to receive the Traditional SLT treatment which will act as a control for the experimental arm. Note that both lasers are Standard of Care (SOC) and FDA approved

Who Is Running the Clinical Trial?

Medical University of South Carolina

Lead Sponsor

Trials

994

Recruited

7,408,000+