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mRNA-1982 Vaccine for Lyme Disease

Not yet recruiting at 7 trial locations
MW
Overseen ByModerna WeCare Team
Age: 18+
Sex: Any
Trial Phase: Phase 2
Sponsor: ModernaTX, Inc.
Disqualifiers: Anaphylaxis, Chronic Lyme, Recent tick bite, others
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

This clinical study will evaluate the safety, reactogenicity, and immunogenicity of monovalent mRNA-1982, a messenger ribonucleic acid (mRNA) vaccine to prevent Lyme disease in healthy adults aged 18 to 70 years old.

Are You a Good Fit for This Trial?

Inclusion Criteria

* In good general health in the opinion of the investigator as determined by medical evaluation including medical history and physical examination at screening.
* Contraceptive use by participants should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies.
Key

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Dose-finding Phase

Participants will receive mRNA-1982 or placebo as an intramuscular injection

4 weeks

Booster Phase

Participants will receive mRNA-1982 (as a booster) or placebo as an intramuscular injection

4 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment

12 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • mRNA-1982

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Group I: Dose-finding PhaseExperimental Treatment2 Interventions
Group II: Booster PhaseExperimental Treatment2 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

ModernaTX, Inc.

Lead Sponsor

Trials
127
Recruited
66,790,000+

Dr. Stephen Hoge

ModernaTX, Inc.

Chief Medical Officer

MD from Harvard Medical School

Stéphane Bancel profile image

Stéphane Bancel

ModernaTX, Inc.

Chief Executive Officer since 2011

MBA from Harvard Business School, MSc in Engineering from École Centrale Paris

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