Pharmacist-led de-escalation for Community-acquired Pneumonia

Indian River Hospital, Vero Beach, FL
Community-acquired Pneumonia+2 More ConditionsPharmacist-led de-escalation - Other
All Sexes
What conditions do you have?

Study Summary

This trial will test if reducing exposure to broad-spectrum antibiotics can help detect & reduce infections faster.

Eligible Conditions
  • Community-acquired Pneumonia
  • Antimicrobial Stewardship
  • Point of Care Testing

Treatment Effectiveness

Study Objectives

1 Primary · 21 Secondary · Reporting Duration: days from the time of admission to the time of discharge

Up to 48 hours
detection of influenza virus (yes/no)
viral testing ordered (yes/no)
Hour 72
Cross Infection
Day 21
days from the time of admission to the time of discharge
hospital length-of-stay (days, hours)
Day 21
Number of days of broad-spectrum antibiotic therapy
Day 21
Day 21
total inpatient cost (from hospital's cost accounting system)
up to 14 days
14-day mortality
up to 21 days
ICU transfer after admission (> 24 hours after admission)
Kidney Failure, Acute
total duration of any antibacterial antibiotic
up to 30 days
30-day mortality
Day 30
30-day readmission (yes/no)
up to 48 hours
S. pneumoniae urinary antigen test (UAT) performed
detection of RSV (yes/no)
Atypical Bacterial Forms
Pneumococcal vaccine
Pharmaceutical Preparations
Month 6
Communicable Diseases
within 21 days
Antiviral Agents
Hour 72
de-escalation by 72 hours from admission (yes/no)

Trial Safety

Awards & Highlights

No Placebo Group
All patients enrolled in this trial will receive the new treatment.

Trial Design

4 Treatment Groups

Pharmacist-led de-escalation
1 of 4
Rapid diagnostic testing (RDT)
1 of 4
Rapid diagnostic testing (RDT) and Pharmacist-led de-escalation
1 of 4
Usual care (no intervention)
1 of 4

Active Control

12500 Total Participants · 4 Treatment Groups

Primary Treatment: Pharmacist-led de-escalation · No Placebo Group · N/A

Pharmacist-led de-escalation
ActiveComparator Group · 1 Intervention: Pharmacist-led de-escalation · Intervention Types: Other
Rapid diagnostic testing (RDT)
ActiveComparator Group · 1 Intervention: Rapid Diagnostic Testing · Intervention Types: DiagnosticTest
Rapid diagnostic testing (RDT) and Pharmacist-led de-escalationActiveComparator Group · 2 Interventions: Pharmacist-led de-escalation, Rapid Diagnostic Testing · Intervention Types: Other, DiagnosticTest
Usual care (no intervention)NoIntervention Group · 1 Intervention: Usual care (no intervention) · Intervention Types:

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: days from the time of admission to the time of discharge

Who is running the clinical trial?

The Cleveland ClinicLead Sponsor
968 Previous Clinical Trials
1,348,756 Total Patients Enrolled
Michael Rothberg, M.D.Principal InvestigatorThe Cleveland Clinic
1 Previous Clinical Trials
3,000 Total Patients Enrolled

Eligibility Criteria

Age 18+ · All Participants · 0 Total Inclusion Criteria

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Frequently Asked Questions

How many participants have contributed to this research endeavor?

"Affirmative. The website reveals that the trial, which first went live on November 1st 2022, is still in search of participants. A total of 12500 patients must be recruited from 4 distinct sites to complete the study." - Anonymous Online Contributor

Unverified Answer

Are there any Canadian medical facilities conducting this research project?

"As of right now, the 4 sites running this medical trial are located in Avon, Fairview Park, Garfield Heights and multiple other areas. To facilitate participation, it is advisable to pick the closest clinic available so that any travel demands can be minimized." - Anonymous Online Contributor

Unverified Answer

Does this research offer any vacancies for participants?

"Affirmative. As per the information available on, this medical trial remains open and is currently seeking participants. It was announced on November 1st 2022 with a subsequent update made 13 days later; 12500 individuals are required to be recruited from 4 different medical centres." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.