LIFU for Alzheimer's Disease
Trial Summary
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but if you are on AChEI or memantine, you must have been on a stable dose for at least 45 days.
What data supports the effectiveness of the treatment Low-Intensity Focused Ultrasound (LIFU) for Alzheimer's Disease?
Research shows that Low-Intensity Focused Ultrasound (LIFU) can open the blood-brain barrier (a protective layer around the brain) and potentially improve brain activity. In a pilot study, LIFU was explored for its effects on Alzheimer's patients, focusing on brain metabolism and cognitive function, although its full effectiveness and safety in humans are still being studied.12345
How is the LIFU treatment for Alzheimer's disease different from other treatments?
What is the purpose of this trial?
This study is a prospective, single-center, single-arm early feasibility study, to establish safety and tolerability of LIFU for neuromodulation in patients with mild cognitive impairment ( MCI) due to Alzheimer's disease.
Research Team
Ali Rezai, MD
Principal Investigator
WVU Rockefeller Neuroscience Institute
Eligibility Criteria
This trial is for men and women aged 45-85 who can communicate during the procedure, have mild cognitive impairment due to Alzheimer's, and are not pregnant. Participants must be able to consent and if taking certain Alzheimer's medications, they should be on a stable dose for at least 45 days.Inclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo Exablate low intensity focused ultrasound neuromodulation
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Low-Intensity Focused Ultrasound (LIFU)
Low-Intensity Focused Ultrasound (LIFU) is already approved in United States, Canada, Japan for the following indications:
- Mild Cognitive Impairment (MCI) due to Alzheimer's disease
- Research use for neuromodulation
- Research use for neuromodulation in Alzheimer's disease
- Research use for neuromodulation in Alzheimer's disease
Find a Clinic Near You
Who Is Running the Clinical Trial?
Ali Rezai
Lead Sponsor