375 Participants Needed

Exercise for Urge Urinary Incontinence

(MOVEONUP Trial)

UU
JV
Overseen ByJulia Vresilovic
Age: 65+
Sex: Female
Trial Phase: Academic
Sponsor: University of Pennsylvania
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. However, it mentions that participants should not plan to start new treatments for urinary incontinence or overactive bladder during the study.

What data supports the effectiveness of the treatment for urge urinary incontinence?

Research shows that pelvic floor muscle training, including Kegel exercises, is commonly used and effective for stress urinary incontinence and is sometimes recommended for urge urinary incontinence. Physical therapy interventions have also been shown to improve pelvic floor muscle strength, which can help manage urinary incontinence.12345

Is exercise safe for treating urinary incontinence?

Exercise, particularly pelvic floor exercises like Kegel exercises, is generally considered safe for treating urinary incontinence. These exercises have been used for many years and are recommended as a first-line treatment for urinary incontinence, with no significant safety concerns reported in the research.26789

How is the exercise treatment for urge urinary incontinence different from other treatments?

This exercise treatment focuses on strengthening the pelvic floor muscles through specific exercises like Kegel exercises, which are unique because they target the muscles that support the bladder and help control urination. Unlike medications or surgical options, this approach is non-invasive and can be more effective when supervised by a specialist, especially for stress urinary incontinence.1791011

What is the purpose of this trial?

A prospective, two-arm randomized clinical trial utilizing a multidimensional intervention to reduce falls in older women with Urinary Urge Incontinence. The intervention consist of general balance and strength training, bladder training and urge suppression, and home hazard assessments. The control group will receive informational booklets on fall prevention and behavioral treatment for urinary urge incontinence.

Research Team

UU

Uduak Andy, MD

Principal Investigator

University of Pennsylvania

Eligibility Criteria

The MoVEonUp trial is for women aged 70 or older who live independently, can consent and communicate in English, are not very physically active, and have moderate to severe urge-predominant urinary incontinence. They should be able to participate in an exercise program without harming their health as confirmed by a doctor.

Inclusion Criteria

I live on my own and manage my daily activities.
I am not planning to start new treatments for urinary issues during the study.
I can walk on my own or with help from a device.
See 8 more

Exclusion Criteria

You have a heart condition that is not stable according to your own report.
Not willing to sign Consent Form
I have a pelvic organ prolapse that extends beyond the vaginal opening.
See 11 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants in the exercise group will participate in home-based exercises including balance and strength training, bladder training, and home hazard assessments. The control group will receive informational booklets on fall prevention and behavioral treatment for urinary urge incontinence.

12 months

Follow-up

Participants are monitored for changes in urinary incontinence and number of falls over the course of the trial

12 months

Treatment Details

Interventions

  • Exercise Group
Trial Overview This study tests if exercises that improve balance and strength combined with bladder training can reduce falls in older women with Urinary Urge Incontinence. Participants will either join the exercise group or receive educational booklets on fall prevention.
Participant Groups
2Treatment groups
Active Control
Group I: Exercise GroupActive Control1 Intervention
Participants in this group will participate in the home-based exercise group intervention that consists of general balance and strength training, bladder training and urge suppression, and home hazard assessments.
Group II: Control GroupActive Control1 Intervention
Participants in this group will receive informational booklets on fall prevention and behavioral treatment for Urgency Incontinence.

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Pennsylvania

Lead Sponsor

Trials
2,118
Recruited
45,270,000+

Findings from Research

In a review of 21 trials involving 1490 women, pelvic floor muscle training with regular supervision (weekly or bi-weekly group sessions) significantly improved outcomes for women with stress urinary incontinence, with only 10% reporting no improvement compared to 43% in the individual supervision group.
Despite the positive findings, the evidence is not strong enough to recommend a specific training approach, highlighting the need for more consistent and well-defined training protocols in future studies.
Comparisons of approaches to pelvic floor muscle training for urinary incontinence in women.Hay-Smith, EJ., Herderschee, R., Dumoulin, C., et al.[2022]
A study involving 91 women with urinary incontinence found that both pelvic floor muscle training (PFMT) and assisted pelvic floor muscle training (APFMT) using the Kegelmaster device significantly improved urinary incontinence symptoms and quality of life after 12 weeks of training.
There was no significant difference in effectiveness between PFMT and APFMT, indicating that both methods are equally beneficial for strengthening pelvic floor muscles and reducing involuntary urine passage.
Evaluation of the effect of pelvic floor muscle training (PFMT or Kegel exercise) and assisted pelvic floor muscle training (APFMT) by a resistance device (Kegelmaster device) on the urinary incontinence in women: a randomized trial.Kashanian, M., Ali, SS., Nazemi, M., et al.[2022]
Pelvic floor muscle training (PFMT) is effective for women with urinary incontinence, showing that those who participated in PFMT were more likely to report improvement or cure compared to those who did not, based on a review of 13 trials involving 714 women.
While PFMT generally resulted in about one fewer incontinence episode per day, the studies showed significant variability in methods and outcomes, suggesting that younger women with stress urinary incontinence may benefit the most from longer, supervised training programs.
Pelvic floor muscle training versus no treatment, or inactive control treatments, for urinary incontinence in women.Hay-Smith, EJ., Dumoulin, C.[2022]

References

Comparisons of approaches to pelvic floor muscle training for urinary incontinence in women. [2022]
Evaluation of the effect of pelvic floor muscle training (PFMT or Kegel exercise) and assisted pelvic floor muscle training (APFMT) by a resistance device (Kegelmaster device) on the urinary incontinence in women: a randomized trial. [2022]
Pelvic floor muscle training versus no treatment, or inactive control treatments, for urinary incontinence in women. [2022]
Comparative analysis of biofeedback and physical therapy for treatment of urinary stress incontinence in women. [2019]
The effect of outpatient physical therapy intervention on pelvic floor muscles in women with urinary incontinence. [2013]
Nonsurgical management of pelvic floor dysfunction. [2019]
There is not yet strong evidence that exercise regimens other than pelvic floor muscle training can reduce stress urinary incontinence in women: a systematic review. [2018]
Does a Kegel Exercise Program Prior to Resistance Training Reduce the Risk of Stress Urinary Incontinence? [2023]
Pelvic floor exercise for urinary incontinence: a systematic literature review. [2022]
[Comparison of pelvic floor muscle strength in competition-level athletes and untrained women]. [2019]
The effect of pelvic floor exercises on urethral function in female stress urinary incontinence: an urodynamic study. [2004]
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