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Palifermin for Stem Cell Transplant Outcomes
Study Summary
This trial is testing whether the drug palifermin can help improve the results of stem cell transplants from HLA-matched unrelated donors.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I don't have a family donor but may have a match in a donor registry.I have been diagnosed with a blood cancer that meets certain criteria.My acute lymphoblastic leukemia is in its first complete remission.I meet the specific criteria for myelofibrosis treatment.You live outside of the United States.My donor's HLA type matches mine at the A, B, and C genes.My AML is in its first complete remission.I have an infection that isn't getting better with treatment.I had another cancer but was treated successfully and have been cancer-free for 5 years.I am 18 years old or older.I can care for myself but may need occasional help.I haven't had any cancer except for skin cancer in the last 5 years.My cancer has spread to my brain or spinal cord.My lymphoma meets specific requirements.My multiple myeloma is in complete remission.My vital organs are functioning well.I am HIV positive.I have had a condition where my lymphocytes grow abnormally.
- Group 1: 1/Phase 1: Dose escalation arm
- Group 2: 2/ Phase II arm
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Are researchers still looking for people to participate in this trial?
"The trial is currently ongoing, with the most recent update being on October 8th, 2022. The study was originally posted September 24th, 2015."
Are there other ongoing or completed research trials that have used Hematopoietic stem cell transplantation?
"The first study investigating hematopoietic stem cell transplant was published in 1993. Since then, 849 similar studies have been completed while 425 are still ongoing. A large number of the active trials are being conducted in Minneapolis, Minnesota."
How many test subjects are participating in this experiment?
"That is correct, the listing on clinicaltrials.gov currently indicates that this trial is open for recruitment. This particular study was first posted on September 24th, 2015 and most recently updated on October 8th, 2022. They are looking to enroll 50 patients at 3 different locations."
How is Hematopoietic stem cell transplant most often helpful to patients?
"Diffuse large b-cell lymphoma (dlbcl) patients often respond well to hematopoietic stem cell transplants. This treatment is also effective for other conditions, like B-cell lymphomas, polyangiitis, and pemphigus vulgaris."
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