MR-Guided Focused Ultrasound for Breast Cancer
(BreastMRgFUS Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial is testing the Muse MRgFUS System, which uses sound waves guided by MRI to partially destroy breast tumors. It targets breast cancer patients with multiple tumor sites. The sound waves heat and kill part of the tumor while MRI ensures precise targeting. This noninvasive technique has been shown to treat both benign and malignant tumors.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial team or your doctor.
Is MR-guided focused ultrasound generally safe for humans?
How is the MR-guided focused ultrasound treatment different from other breast cancer treatments?
What data supports the effectiveness of the treatment MR-Guided Focused Ultrasound for Breast Cancer?
Research shows that MR-guided focused ultrasound (MRgFUS) is effective in treating both benign and malignant tumors, including breast cancer, by using heat to destroy the tumor without surgery. It has also been used successfully for pain relief in bone cancer patients, suggesting its potential for treating other types of cancer.12568
Who Is on the Research Team?
Cindy Matsen, MD
Principal Investigator
Huntsman Cancer Institute
Are You a Good Fit for This Trial?
This trial is for women under 50 with unilateral, unifocal invasive breast cancer planning a lumpectomy. They must be able to lie prone for 90 minutes, have no severe allergies to gadolinium contrast or sedatives, and not have had prior radiation in the affected breast or certain other cancers within the last two years. Participants should not be pregnant and must use effective contraception if of childbearing potential.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Subjects undergo partial ablation of half (≤50%) of one of their tumors followed by surgical resection per standard of care
Follow-up
Participants are monitored for safety and effectiveness after treatment, including evaluation of adverse events and ablation efficacy
Long-term Follow-up
Estimate disease-free survival (DFS) and overall survival (OS) at 5 years post ablation
What Are the Treatments Tested in This Trial?
Interventions
- Muse MRgFUS System
Muse MRgFUS System is already approved in United States, European Union for the following indications:
- Investigational device exemption for clinical trials in human subjects with breast cancer
- Clinical trials for breast cancer treatment
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Utah
Lead Sponsor