~3 spots leftby Dec 2025

Caloric Vestibular Stimulation for OCD

PM
MF
Overseen ByMaria Filippou-Frye, MD, MBS
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: Stanford University
Disqualifiers: Vertigo, Otological surgery, Substance use, others
No Placebo Group
Approved in 2 Jurisdictions

Trial Summary

What is the purpose of this trial?

This trial investigates if using warm or cold water in the ear can help people with obsessive-compulsive disorders better understand their condition by stimulating certain brain areas.

Do I need to stop taking my current medications to join the trial?

The trial does not specify if you need to stop taking your current medications, but it mentions that there should be no recent change in your psychopharmacological treatment (medications for mental health conditions). This suggests you may need to stay on your current medications without changes.

Is caloric vestibular stimulation safe for humans?

Caloric vestibular stimulation, using either water or air, is generally safe for humans, but it can cause discomfort such as nausea and should be avoided in cases of ear infections or perforated eardrums. Studies have shown it is used safely in both adults and children, although children may find the water test more uncomfortable.12345

How is Caloric Vestibular Stimulation treatment different from other OCD treatments?

Caloric Vestibular Stimulation is unique because it involves using temperature changes in the ear canal to stimulate the vestibular system, which is different from typical OCD treatments that often involve medication or cognitive-behavioral therapy. This method is traditionally used to assess balance and hearing issues, making its application for OCD novel.23467

Research Team

PJ

Peter van Roessel, MD, PhD

Principal Investigator

Stanford University

Eligibility Criteria

This trial is for adults aged 18-65 with a primary diagnosis of Obsessive-Compulsive Disorder, Body Dysmorphic Disorder, Illness Anxiety Disorder, or Somatic Symptom Disorder. Participants should not have had recent changes in any psychopharmacological treatment and must be able to provide informed consent. Pregnant or nursing women, individuals with substance use issues or certain medical conditions like vertigo are excluded.

Inclusion Criteria

You have been diagnosed with certain mental health disorders, including Obsessive-Compulsive Disorder, Body Dysmorphic Disorder, Illness Anxiety Disorder, or Somatic Symptom Disorder (excluding "with predominant pain").
No recent change in psychopharmacological treatment, if any
Age 18-65
See 2 more

Exclusion Criteria

You are currently pregnant or breastfeeding.
You are currently using or have recently used drugs or alcohol.
You have a medical or psychiatric condition, such as vertigo or a history of ear surgery, that could make it unsafe for you to take part in the study.

Trial Timeline

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Treatment

Participants receive unilateral caloric vestibular stimulation with before and after measures of OCRD symptom severity and insight

1 hour
1 visit (in-person)

Follow-up

Participants are monitored for changes in clinical insight using the Brown Assessment of Beliefs Scale

1-2 weeks

Treatment Details

Interventions

  • Caloric Vestibular Stimulation (Other)
Trial OverviewThe study is testing caloric vestibular stimulation—a procedure that involves stimulating the balance organs in the ears using temperature—to see if it can change how people with obsessive-compulsive spectrum disorders perceive their symptoms.
Participant Groups
2Treatment groups
Experimental Treatment
Group I: right cold caloric vestibular stimulationExperimental Treatment1 Intervention
OCRD participants in this arm will receive an approx 60 second infusion of distilled cold(4)c water in their right external ear canal, with before and after measures of OCRD symptom severity and insight.
Group II: left cold caloric vestibular stimulationExperimental Treatment1 Intervention
OCRD participants in this arm will receive an approx 60 second infusion of distilled cold(4)c water in their left external ear canal, with before and after measures of OCRD symptom severity and insight.

Find a Clinic Near You

Who Is Running the Clinical Trial?

Stanford University

Lead Sponsor

Trials
2,527
Recruited
17,430,000+

Findings from Research

The air caloric test, which uses air instead of water, is better tolerated by children and can be effectively used to evaluate vestibular function, showing significant differences in results compared to the traditional water test.
In a study of 27 children aged 5 to 14, the air test produced a lower maximum slow speed component (2.98 degrees/s) compared to the water test (4.74 degrees/s), indicating that while the two methods differ, the air test is a viable alternative for assessing labyrinthine function in pediatric patients.
Comparison between air and water caloric tests in children.Melagrana, A., D'Agostino, R., Ravera, B., et al.[2019]
Caloric stimulation is an effective clinical test for assessing vestibular function in neonates, particularly useful for identifying vestibular disorders in infants with sensorineural hearing loss, which affects 20% to 70% of this population.
In a study of 58 high-risk infants aged 3 to 6 months, about 34% showed a weaker nystagmic reaction to cold water compared to healthy controls, especially those with perinatal issues or congenital defects, highlighting the need for careful testing methods.
[Caloric stimulation in infants].Zagólski, O.[2006]
The study analyzed caloric responses from 2587 patients, identifying significant differences in response magnitudes between warm and cool water stimuli, with warm water eliciting stronger responses.
Both air and water stimuli can effectively distinguish between normal vestibular function and bilateral vestibular weakness, achieving high sensitivity and specificity (0.82 to 0.84), suggesting that air caloric tests can be a reliable alternative to water tests when properly calibrated.
A comparison of water and air caloric responses and their ability to distinguish between patients with normal and impaired ears.Zapala, DA., Olsholt, KF., Lundy, LB.[2008]

References

Comparison between air and water caloric tests in children. [2019]
[Caloric stimulation in infants]. [2006]
A comparison of water and air caloric responses and their ability to distinguish between patients with normal and impaired ears. [2008]
What does the video head impulse test tell us about post-caloric vestibular recruitment? [2023]
A protocol for the air caloric test and a comparison with a standard water caloric test. [2019]
Comparison of vestibular autorotation and caloric testing. [2017]
Evaluation of a screening-procedure by hot-water caloric tests. [2009]