LIFUP Dose Group 1 for Mild Cognitive Impairment
Study Summary
This trial is testing whether a new brain stimulation technique can improve memory in people with early Alzheimer's disease.
- Mild Cognitive Impairment
- Deep Brain Stimulation
Treatment Effectiveness
Effectiveness Progress
Study Objectives
2 Primary · 5 Secondary · Reporting Duration: 4 years
Trial Safety
Safety Progress
Trial Design
4 Treatment Groups
LIFUP Dose Group 1
1 of 4
LIFUP Dose Group 3
1 of 4
LIFUP Dose Group 2
1 of 4
Sham LIFUP
1 of 4
Active Control
Non-Treatment Group
144 Total Participants · 4 Treatment Groups
Primary Treatment: LIFUP Dose Group 1 · Has Placebo Group · N/A
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 50 - 90 · All Participants · 6 Total Inclusion Criteria
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- Stephen, James H., Casey H. Halpern, Cristian J. Barrios, Usha Balmuri, Jared M. Pisapia, John A. Wolf, Kyle M. Kampman, Gordon H. Baltuch, Arthur L. Caplan, and Sherman C. Stein. 2012. “Deep Brain Stimulation Compared with Methadone Maintenance for the Treatment of Heroin Dependence: A Threshold and Cost-effectiveness Analysis”. Addiction. Wiley. doi:10.1111/j.1360-0443.2011.03656.x.
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- Hescham, Sarah, Lee Wei Lim, Ali Jahanshahi, Arjan Blokland, and Yasin Temel. 2013. “Deep Brain Stimulation in Dementia-related Disorders”. Neuroscience & Biobehavioral Reviews. Elsevier BV. doi:10.1016/j.neubiorev.2013.09.002.
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- Taylor Kuhn 2022. "Modulation of Hippocampal Circuitry and Memory Function With Focused Ultrasound in Amnestic MCI". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05417555.
Frequently Asked Questions
What do researchers hope to gain from this experiment?
"This 40 minute trial has been designed to measure changes in Perfusion Arterial Spin Labeling (ASL) fMRI Signal throughout the Brain. Secondary outcomes involve assessing memory through Rey Verbal Learning Test Scores, which involves recalling a list of 15 words over 5 trials and 30 minutes later as an indicator for short-term and long-term memory respectively; post-hoc biomarker analysis of plasma AB42/40 ratio as predictor of tFUS efficacy, where values lower than 0.160 suggest high risk for Alzheimer's Disease; lastly, post-hoc biomarker analysis involving APOE-4 status to predict" - Anonymous Online Contributor
Is recruitment still underway for this clinical procedure?
"The information posted on clinicaltrials.gov attests to this study not currently recruiting patients, having been initially launched on September 1st 2022 and last updated 2 days later. Nonetheless, there are 602 other active trials that are looking for participants at the present moment." - Anonymous Online Contributor
Are people over 55 years old being accepted as participants in this research endeavor?
"Candidates aged 50 and above, but below 90 years old are being admitted to this clinical study." - Anonymous Online Contributor
Who is eligible to join this medical experiment?
"This research requires the recruitment of 144 individuals aged 50 to 90, all with a pre-existing Deep Brain Stimulation treatment. Additionally, these participants must be diagnosed with Amnestic Mild Cognitive Impairment (MCI), English speaking, right handed; and have normal hearing or vision that can be corrected as necessary. Further, they must also agree to provide informed consent through UBACC protocols put forward in 2007 by Jeste et al." - Anonymous Online Contributor