← Back to Search

Other

Pain Management Medications for Postoperative Pain

Phase 2

Waitlist Available

Led By SAM P Most, MD

Research Sponsored by Stanford University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Undergoing rhinoplasty for cosmetic purposes

Minimum age of 18 years

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 5 days

Awards & highlights

Study Summary

This trial will compare the effectiveness of two different post-operative pain medication regimens in order to determine which is more effective in managing pain after nasal surgery.

Who is the study for?

This trial is for adults over 18 who speak English and are having rhinoplasty either for cosmetic reasons or to treat nasal obstruction. It excludes pregnant or lactating women, those with allergies to pain meds used in the study, and anyone not undergoing nasal surgery.Check my eligibility

What is being tested?

The study compares postoperative pain control using two combinations of medications after nasal surgery: Acetaminophen (325mg) + Hydrocodone (5mg) versus Acetaminophen (325mg) + Ibuprofen (200mg), taken over a period of 5 days.See study design

What are the potential side effects?

Possible side effects may include gastrointestinal issues like stomach pain or ulcers from Ibuprofen, liver damage from Tylenol if overdosed, and dizziness, nausea, or constipation from Norco.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am planning to have a nose job for cosmetic reasons.

Select...

I am at least 18 years old.

Select...

I am having a nose surgery to fix my blocked nose.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 5 days

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~5 days

This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Pain intensity Visual Analog Scale (VAS)- 0-100 (0- no pain and 100- most severe pain)

Secondary outcome measures

Side effects of pain medications

Trial Design

2Treatment groups

Active Control

Group I: DRUG ARM BActive Control2 Interventions

Tylenol 325Mg Caplet, administered orally every 4 hours for 5 days total. Ibuprofen 200 mg administered orally every 4 hours for 5 days total.

Group II: DRUG ARM AActive Control1 Intervention

Norco 5Mg-325Mg Tablet, administered orally every 4 hours for 5 days total

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

Stanford UniversityLead Sponsor

2,386 Previous Clinical Trials

17,333,957 Total Patients Enrolled

7 Trials studying Postoperative Pain

1,042 Patients Enrolled for Postoperative Pain

SAM P Most, MDPrincipal InvestigatorStanford University

Media Library

Ibuprofen 200 mg (Other) Clinical Trial Eligibility Overview. Trial Name: NCT03584152 — Phase 2

Postoperative Pain Research Study Groups: DRUG ARM B, DRUG ARM A

Postoperative Pain Clinical Trial 2023: Ibuprofen 200 mg Highlights & Side Effects. Trial Name: NCT03584152 — Phase 2

Ibuprofen 200 mg (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03584152 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Has DRUG ARM B been sanctioned by the FDA?

"With clinical data providing evidence of safety, DRUG ARM B received a rating of 2 on the scale. However, as this is only a Phase 2 trial there are no studies to indicate its efficacy yet."

Answered by AI

What therapeutic purpose does DRUG ARM B typically serve?

"DRUG ARM B is an efficacious treatment for catarrh, rhinorrhoea, and musculoskeletal pain."

Answered by AI

How many participants are enrolled in this clinical experiment?

"Unfortunately, this trial has closed its recruitment period; it was initially posted on August 9th 2019 and last updated on May 5th 2022. However, there are currently 480 trials seeking participants with pain or postoperative conditions and 109 studies for DRUG ARM B looking for volunteers."

Answered by AI

Is recruitment for this research still ongoing?

"According to clinicaltrials.gov, this medical trial is not recruiting at the moment; it was initially posted on August 9th 2019 and edited lastly on May 5th 2022. Nonetheless, there are approximately five hundred and eighty-nine other studies enrolling patients currently."

Answered by AI

What other clinical experiments have featured DRUG ARM B?

"At present, 109 clinical trials are being conducted for DRUG ARM B with 32 of those in Phase 3. Most studies occur in Pittsburgh, Pennsylvania; however, 1031 locations worldwide have been chosen to facilitate research into this treatment."

Answered by AI

Recent research and studies

JAMA Facial Plastic SurgeryJournal

Opioid Use by Patients After Rhinoplasty

Patel, Sagar, Angela Sturm, Michael Bobian, Peter F. Svider, Giancarlo Zuliani, and Russell Kridel. 2018. “Opioid Use by Patients After Rhinoplasty”. JAMA Facial Plastic Surgery. Mary Ann Liebert Inc. doi:10.1001/jamafacial.2017.1034.

JAMA Facial Plastic SurgeryJournal

Opioid Use by Patients After Rhinoplasty

clinicaltrials.govStudy

Postoperative Pain Management in Rhinoplasty

Sam P. Most 2019. "Postoperative Pain Management in Rhinoplasty". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03584152.