Catheter Ablation for Atrial Fibrillation
(ARIADNE RCT Trial)
Trial Summary
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial team or your doctor.
What data supports the effectiveness of the treatment Catheter Ablation for Atrial Fibrillation?
Is catheter ablation generally safe for humans?
Catheter ablation for atrial fibrillation is generally considered safe, but it does carry some risks, especially since it is a complex procedure. Studies have shown that there can be complications, particularly in patients with other heart conditions, but understanding and managing these risks can help improve safety.678910
How does catheter ablation differ from other treatments for atrial fibrillation?
Catheter ablation is a unique treatment for atrial fibrillation because it involves using a thin tube (catheter) to deliver energy to the heart tissue, creating small scars that help restore a normal heart rhythm. Unlike antiarrhythmic drugs, which are often used first, catheter ablation directly targets the heart's electrical pathways and is typically considered when medications are not effective.24111213
What is the purpose of this trial?
A prospective multi-arm parallel group randomized clinical trial to compare the efficacy of three ablation strategies in patients with persistent atrial fibrillation using using a lattice-tip catheter that can switch between RFA and PFA energy. The incremental benefit of posterior wall isolation (PWI) and mitral isthmus ablation may contribute to greater freedom from atrial fibrillation at twelve months.
Research Team
Stavros Mountantonakis, MD
Principal Investigator
Northwell Health
Eligibility Criteria
The ARIADNE trial is for adults aged 18-80 with persistent atrial fibrillation, documented by a physician and ECG, lasting more than 7 days but less than 12 months. Candidates must be suitable for catheter ablation and able to follow the study's procedures. Exclusions include severe lung or heart conditions, recent MI or stroke, BMI over 40, clotting/bleeding issues, drug/alcohol dependency, and other specific medical exclusions.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Patients undergo catheter ablation for persistent AF using a lattice-tip catheter with RFA and PFA energy
Monitoring
Patients receive an implantable loop recorder for continuous monitoring of AF/AT/AFL recurrence
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Catheter Ablation
Find a Clinic Near You
Who Is Running the Clinical Trial?
Stavros E Mountantonakis
Lead Sponsor