Study Summary
This trial tests a long-acting growth hormone product given once/wk vs daily injections in kids with Turner Syndrome in the US. 48 kids (12/arm) will be randomized.
- Turner Syndrome
Treatment Effectiveness
Effectiveness Progress
Study Objectives
0 Primary · 4 Secondary · Reporting Duration: 26 weeks, 52 weeks and 104 weeks
Trial Safety
Safety Progress
Trial Design
4 Treatment Groups
Somatropin at 0.05 mg/kg/day
1 of 4
Lonapegsomatropin at 0.24 mg hGH/kg/week
1 of 4
Lonapegsomatropin at 0.30 mg hGH/kg/week
1 of 4
Lonapegsomatropin at 0.36 mg hGH/kg/week
1 of 4
Active Control
Experimental Treatment
48 Total Participants · 4 Treatment Groups
Primary Treatment: Lonapegsomatropin at 0.24 mg hGH/kg/week · No Placebo Group · Phase 2
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 1 - 10 · Female Participants · 5 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:Frequently Asked Questions
Is the trial open to minors?
"This research project is looking for participants that are younger than 10 years of age and older than a year." - Anonymous Online Contributor
How many established healthcare facilities are conducting this research?
"Currently, 17 research sites are participating in this clinical trial. These locations stretch across the country from Palo Alto to Aurora and San Diego as well as 14 other cities. To minimize travel requirements, it is best to choose a site nearest you if you decide to join the study." - Anonymous Online Contributor
Is Lonapegsomatropin dosage of 0.24 mg hGH/kg/week safe for patients?
"Currently, Lonapegsomatropin administered in doses of 0.24 mg hGH/kg/week is evaluated to be relatively safe with a score of 2 due to Phase 2 trial data indicating some evidence for safety but no efficacy results yet." - Anonymous Online Contributor
Does this trial have vacancies for participants at present?
"Clinicaltrials.gov reports that this medical study, which initial posting was on January 1st 2023, is not actively enrolling participants at the moment. However, there are 1369 other clinical trials currently in progress and open to patient recruitment." - Anonymous Online Contributor
Could I register to participate in this clinical trial?
"This clinical trial is seeking 48 prepubertal children who have been diagnosed with Turner Syndrome and are between 1 - 10 years of age. Additional criteria must be met by participants, including having a height lower than the 10th percentile for sex/age according to 2000 CDC Growth Charts for America, bone age at no more than their chronological age on left wrist radiograph scans during screening, biochemically euthyroid without signs or symptoms of intracranial hypertension or proliferative retinopathy in fundoscopy screenings, and stable doses of hormone replacement therapies (other than growth hormones) taken four weeks prior to Screening onwards." - Anonymous Online Contributor