This trial is evaluating whether Colchicine will improve 1 primary outcome and 4 secondary outcomes in patients with Insulin Resistance. Measurement will happen over the course of From baseline to 3 months.
This trial requires 500 total participants across 6 different treatment groups
This trial involves 6 different treatments. Colchicine is the primary treatment being studied. Participants will be divided into 2 treatment groups. Some patients will receive a placebo treatment. The treatments being tested are in Phase 2 and have already been tested with other people.
"Inflammatory responses in tissues are often activated by a host attempting to eliminate an infection or to limit other damage caused by an inflammatory stimulus. Inflammation is one of the most common forms of cellular response to an infection or inflammation, and is also involved in both adaptive and innate immunity. In the context of infection, immune activation and inflammation occurs over time as a means to restore innate and adaptive immune functions in response to persistent antigenic stimuli. Both adaptive and innate immune responses may be stimulated by inflammation, and the two are not mutually exclusive." - Anonymous Online Contributor
"In the United States around 0.5% of people with arthritis are under the age of 30, 4% are under 40, and 19% of those diagnosed are over 70. In Europe it is estimated that 7% of the population has some form of inflammatory arthritis, however, only 3–4% of these are under 30 years of age." - Anonymous Online Contributor
"Inflammation, a physical response, occurs as a defense mechanism, aimed primarily at destroying invading microorganisms that may threaten the host. The body's natural defenses can be overused and result in a wide range of undesirable side effects. As a result, some clinicians use anti-inflammatory agents whenever possible.\n\n- Inflammation." - Anonymous Online Contributor
"There are many medications to treat inflammation, most commonly targeting cytokines with different methods. A combination of medications with a similar mechanism of action produces the greatest benefit. In general, nonpharmaceutical treatment and, preferably, dietary supplements show efficacy for most inflammatory conditions. Dietary supplements should not replace standard treatment, but should be utilized as an adjunct and complement." - Anonymous Online Contributor
"Inflammation is associated with many neurological/neural signals. Specifically, inflammation affects the brain, spinal cord, and brainstem. It can effect mood, behavioural, motor and sensory functions, as well as alter appetite." - Anonymous Online Contributor
"Inflammation is difficult to cure by any means. All treatments should be carefully tailored to the patient and the treatment plan that may be most effective for each case." - Anonymous Online Contributor
"It is important, because inflammatory processes begin at an early age, and that you may have them even before you feel any signs of a chronic illness. Inflammation is a very common process that occurs in adults and children." - Anonymous Online Contributor
"The most frequent side effects in this survey were gastrointestinal, including nausea, abdominal cramps, and diarrhea. Gastrointestinal symptoms were generally mild and tolerable with medication. In one study the side effect that had the greatest impact on patients was joint pain. The frequency of nausea and vomiting decreased with use of colchicine and this was a benefit to patients. Although colchicine significantly improved the symptoms of arthritis for some people, only half of patients improved on the measure that was used." - Anonymous Online Contributor
"Side effects can be minimized with medication education and routine symptom monitoring. Colchicine can cause a mild nausea, a high heart rate, an irregular or slow heartbeat, feeling uneasy when starting with a new medication and feeling tired. Colchicine can also lower calcium levels, which may cause bone fractures or tooth decay, as well as other serious problems. In rare cases, colchicine may cause allergic reactions or skin irritation. It may also increase the risk of some infections, particularly if taken at the same time as another blood thinner, warfarin, or corticosteroids. More serious and serious infections can occur when people with other allergies run the risk of developing a more serious allergic reaction." - Anonymous Online Contributor
"We suggest that when colchicine is being used in conjunction with any other treatments, it is prudent to consider the most common side effects of all drugs. Findings from a recent study indicate that there is a potential risk of liver failure if colchicine is used in combination with other drugs that could cause liver dysfunction." - Anonymous Online Contributor
"Inflammation is now considered to be a central mechanism in MS and its subtypes. Numerous research findings reveal potential opportunities to develop effective and innovative therapies." - Anonymous Online Contributor
"We conclude that the primary cause of inflammation is a combination of factors from three physiological systems activated (1) in response to bacterial-associated signals (2) because of changes (3) in the composition of peripheral lymphoid tissues by peripheral blood lymphocytes as a result of aging, (4) in patients following the initiation of immunosuppressive regimens, and/or (5) as a consequence of the autoimmune diseases in which they were diagnosed." - Anonymous Online Contributor