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Procedure
EBUS for Pulmonary Embolism (VEBUS Trial)
N/A
Waitlist Available
Led By Colleen L Channick, M.D.
Research Sponsored by University of California, Los Angeles
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Intubated patients in the intensive care unit (ICU) where there is a clinical concern for acute pulmonary embolism or a confirmed diagnosis for acute pulmonary embolism.
Patient ≥ 18 years of age.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 years
Awards & highlights
VEBUS Trial Summary
This trial is a prospective, single center study evaluating the role of endobronchial ultrasound in the diagnosis of acute central pulmonary embolism in critically ill patients who cannot undergo a computed tomography angiogram.
Who is the study for?
This trial is for adults over 18 in the ICU suspected of having or confirmed with acute pulmonary embolism, who are intubated and can't be safely moved for a CT scan. They must understand and sign a consent form. It's not for those with an endotracheal tube size under 8.0 mm, contraindications to lidocaine, or unsuitable for bronchoscopy.Check my eligibility
What is being tested?
The study tests if Endobronchial ultrasound (EBUS) can diagnose acute central pulmonary embolism in critically ill patients when a CT scan isn't safe or possible. This pilot study aims to see if EBUS could help decide on urgent treatments without moving unstable patients.See study design
What are the potential side effects?
While specific side effects of EBUS aren't listed here, common ones from similar procedures may include sore throat, coughing, shortness of breath, bleeding at the biopsy site, and infection risk.
VEBUS Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am on a breathing machine in the ICU, suspected or diagnosed with a lung clot.
Select...
I am 18 years old or older.
VEBUS Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 2 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 years
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Assess sensitivity and specificity of EBUS to visualize or exclude PE by its ability to identify a clot.
Assess sensitivity and specificity of EBUS to visualize or exclude PE by its ability to identify flow around clot(s) present.
Assess sensitivity and specificity of EBUS to visualize or exclude PE compared to the chest CT.
+4 moreSecondary outcome measures
Other airway finding(s)
VEBUS Trial Design
3Treatment groups
Experimental Treatment
Active Control
Group I: Patients undergoing standard of care clinical bronchoscopyExperimental Treatment1 Intervention
Patients undergoing clinical bronchoscopy as a part of their standard of care.
The enrolled subjects will be imaged using the flexible bronchoscopy with EBUS.
Group II: Critically Ill PatientsExperimental Treatment1 Intervention
Intubated patients in the intensive care unit (ICU) where there is a clinical concern for acute pulmonary embolism or a confirmed diagnosis for acute pulmonary embolism.
The enrolled subjects will be imaged using the flexible bronchoscopy with EBUS.
Group III: Previously recorded patient media from standard of care clinical bronchoscopy with EBUSActive Control1 Intervention
Patients who underwent a standard of care clinical bronchoscopy with EBUS previously.
Information and media including images and videos that were previously recorded for patients who underwent a standard of care clinical bronchoscopy with EBUS will be available to the study team.
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Who is running the clinical trial?
University of California, Los AngelesLead Sponsor
1,529 Previous Clinical Trials
10,277,791 Total Patients Enrolled
3 Trials studying Pulmonary Embolism
274 Patients Enrolled for Pulmonary Embolism
Colleen L Channick, M.D.Principal InvestigatorUniversity of California, Los Angeles
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- My doctor says I can't have a bronchoscopy.I am on a breathing machine in the ICU, suspected or diagnosed with a lung clot.I am intubated and my doctor has decided I need a bronchoscopy.I am 18 years old or older.You have a breathing tube smaller than 8.0 mm.You should not use lidocaine for medical reasons.
Research Study Groups:
This trial has the following groups:- Group 1: Critically Ill Patients
- Group 2: Patients undergoing standard of care clinical bronchoscopy
- Group 3: Previously recorded patient media from standard of care clinical bronchoscopy with EBUS
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are there any open spots left for volunteers in this research project?
"The information provided on clinicaltrials.gov suggests that this medical study is no longer recruiting participants. Initially posted on August 12th 2019, it was last updated May 22nd 2022; however, 79 other investigations are currently eager to enrol new subjects."
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