Your session is about to expire
← Back to Search
Osmotic Diuretic
Mannitol for Hemodialysis Complications
Phase 2 & 3
Recruiting
Led By Finnian R Mc Causland, MBBCH, MMSc
Research Sponsored by Brigham and Women's Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 4 weeks
Awards & highlights
Study Summary
This trial will compare the effects of mannitol (a sugar alcohol) to placebo on blood pressure and symptoms in adult dialysis patients.
Who is the study for?
This trial is for adults over 18 who are on maintenance hemodialysis for at least 90 days and often have low blood pressure during treatment. They must not be pregnant, planning a kidney transplant soon, or have had a recent heart attack or stroke. Also, they can't join if they're allergic to mannitol or have very high potassium levels.Check my eligibility
What is being tested?
The study is testing whether mannitol can help maintain stable blood pressure in patients who experience significant drops during hemodialysis compared to the usual saline solution. Participants will receive either mannitol or saline while undergoing their regular dialysis treatments.See study design
What are the potential side effects?
Mannitol may cause side effects like fluid overload, electrolyte imbalances (like low sodium), headache, nausea, vomiting, and dizziness. However, these vary from person to person.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 4 weeks
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~4 weeks
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Secondary outcome measures
Intra-dialytic hypotension
Patient Symptoms
Trial Design
2Treatment groups
Experimental Treatment
Placebo Group
Group I: MannitolExperimental Treatment1 Intervention
intravenous 20% mannitol, 0.25g/kg/hour (maximum 25g/hour; maximum 75g per session; maximum volume 375mL/session) as a continuous infusion during dialysis
Group II: PlaceboPlacebo Group1 Intervention
0.9% saline at a rate of 1.25mL/kg/hour (maximum volume 375mL) as a continuous infusion during dialysis
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Mannitol
2019
Completed Phase 4
~2900
Find a Location
Who is running the clinical trial?
Brigham and Women's HospitalLead Sponsor
1,615 Previous Clinical Trials
11,470,800 Total Patients Enrolled
Finnian R Mc Causland, MBBCH, MMScPrincipal InvestigatorBrigham and Women's Hospital
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I undergo hemodialysis three times a week.I have not had a heart attack or stroke in the last month.My blood pressure often drops below 100 mmHg during dialysis.I have been on hemodialysis for more than 90 days.I am allergic to mannitol.My doctor expects I have less than 2 months to live.I am scheduled for a kidney transplant within the next 2 months.I am 18 years old or older.
Research Study Groups:
This trial has the following groups:- Group 1: Mannitol
- Group 2: Placebo
Awards:
This trial has 0 awards, including:Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
For what purpose is Mannitol most often prescribed?
"The medical conditions of glucose tolerance test, glomerular filtration rate measurement, and kidney failure, acute can all be treated by using the medication Mannitol."
Answered by AI
How many people have signed up to participate in this research project?
"That is correct. The information available on clinicaltrials.gov indicates that this clinical trial is recruiting patients at this time. This particular trial was originally posted on April 6th, 2021 and was last edited on May 3rd, 2022. They are looking for a total of 30 patients from 1 location."
Answered by AI
Are patients currently being sought for this clinical trial?
"That is accurate, the clinical trial listed on clinicaltrials.gov is looking for more participants. This particular study was first posted on April 6th, 2021 and updated most recently on May 3rd, 2022. They are recruiting for a total of 30 individuals across 1 location."
Answered by AI
Recent research and studies
Other Trials to Consider
Popular Categories
Share this study with friends
Copy Link
Messenger