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Aerobic Training for Spinocerebellar Ataxias

N/A

Waitlist Available

Research Sponsored by Columbia University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Ability to safely ride a stationary exercise bike

Diagnosed with spinocerebellar ataxia

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 0, 3, 6, and 9 months

Awards & highlights

Study Summary

This trial aims to study how aerobic training affects eyeblink conditioning, which is a type of motor learning related to the cerebellum. The researchers will use a smartphone app called iBlink to test

Who is the study for?

This trial is for individuals with Spinocerebellar Ataxias and related conditions who can perform physical exercises. The study aims to understand if exercise can improve certain brain-related learning processes.Check my eligibility

What is being tested?

The study tests whether aerobic training, compared to balance training, enhances a type of learning linked to the cerebellum in the brain. Participants will use an app called iBlink at home to measure outcomes.See study design

What are the potential side effects?

While specific side effects are not listed, typical risks may include muscle soreness or strain from physical activities like balance and aerobic exercises.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I can safely use a stationary exercise bike.

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I have been diagnosed with spinocerebellar ataxia.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 0, 3, 6, and 9 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~0, 3, 6, and 9 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and 0, 3, 6, and 9 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Conditioned Response (CR) Amplitude

Secondary outcome measures

PROM of Ataxia Score

SARAhome Score

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Aerobic TrainingExperimental Treatment1 Intervention

Participants will be given a stationary exercise bike for home use. They will be instructed to use the exercise bike five times a week for thirty-minute sessions. The exercise intensity prescription will be based on the subject's VO2max determined on pre-test day. The exercise program will start at 60% of intensity per session, and then will be increased by steps of 5% intensity every 2 sessions until participants reach 30 minutes of training at 80% intensity. Participants will be contacted weekly by e-mail or phone to answer any questions about the exercise protocol and will be instructed to log each training session. Participants will record duration of exercise, perceived exertion, average heart rate, maximum heart rate, and distance.

Group II: Balance TrainingActive Control1 Intervention

A physical therapist will tailor a home balance training program for each participant based on pre- training capabilities. Participants will be asked to perform exercises five times a week for thirty-minute sessions. Both dynamic and static exercises will be performed in sitting and standing positions. Exercises will start with stabilizing in a challenging static position and progress to dynamic arm and leg movements in the same or modified position. Participants will be contacted weekly by e-mail or phone to answer any questions about the exercise protocol and will be required to log their exercise effort in terms of frequency and level of balance challenge.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Aerobic Training

2020

N/A

~830

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

Columbia UniversityLead Sponsor

1,433 Previous Clinical Trials

2,460,955 Total Patients Enrolled

4 Trials studying Spinocerebellar Ataxias

292 Patients Enrolled for Spinocerebellar Ataxias

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Which individuals meet the criteria to participate in this research?

"For inclusion in this clinical trial, individuals between the ages of 18 and 80 with spinocerebellar ataxias are sought after. A total of 60 participants will be enrolled for this study."

Answered by AI

Does the clinical trial include individuals who are above 80 years of age?

"Patients who are at least 18 years old and no older than 80 years old meet the age requirements for enrollment in this trial."

Answered by AI

Are potential participants currently able to apply for enrollment in this ongoing clinical trial?

"As per the information provided on clinicaltrials.gov, this particular clinical trial is not currently accepting participants. Although it was initially posted on June 1st, 2024 and last updated on December 11th, 2023, there are still numerous other active trials (approximately 40) that are actively recruiting patients at this time."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Impact of Exercise on Eyeblink Conditioning in Spinocerebellar Ataxias

Scott Barbuto 2024. "Impact of Exercise on Eyeblink Conditioning in Spinocerebellar Ataxias". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06177626.

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