Exercise for Spinocerebellar Ataxias
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether aerobic exercise can improve motor skills in people with spinocerebellar ataxia, a group of disorders affecting balance and coordination. Researchers aim to determine if aerobic exercise aids the brain, particularly the cerebellum, in adapting and enhancing motor learning. Participants will engage in either aerobic training on a stationary bike or balance exercises at home. Individuals diagnosed with spinocerebellar ataxia who can safely ride a stationary bike may be suitable for this study. As an unphased trial, this study provides a unique opportunity to contribute to understanding how exercise might benefit those with spinocerebellar ataxia.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research shows that aerobic exercise is generally safe for people with cerebellar ataxia. In previous studies, participants did not experience serious problems from the exercise. For instance, one study with 31 participants reported no major issues, and over 70% adhered well to the exercise plan. Aerobic exercise has also been found to improve ataxia symptoms, reduce tiredness, and increase fitness levels.
Similarly, balance exercises have helped people with degenerative cerebellar disease by enhancing movement and balance. Research indicates that these exercises can safely improve balance and ataxia symptoms without causing serious side effects.
Overall, both aerobic and balance exercises are well-tolerated and have positive effects in similar conditions. However, it is important to follow guidance and report any concerns to healthcare providers when engaging in any exercise program.12345Why are researchers excited about this trial?
Researchers are excited about these treatments for spinocerebellar ataxias because they focus on non-drug approaches that enhance physical function directly through exercise. Unlike typical symptomatic treatments that might involve medications to manage symptoms, the aerobic and balance training programs are designed to improve the body's coordination and stability from within. The aerobic training uses a progressive intensity approach with a stationary bike, which can boost cardiovascular health and stamina. Meanwhile, balance training is customized and evolves with the participant's progress, targeting both static and dynamic balance skills. These innovative exercise protocols could lead to improved quality of life by directly addressing the physical challenges of spinocerebellar ataxias.
What evidence suggests that this trial's treatments could be effective for spinocerebellar ataxias?
Research has shown that aerobic exercise, which participants in this trial may receive, can alleviate symptoms of cerebellar ataxia. One study found that performing aerobic exercises at home improved symptoms, reduced fatigue, and increased overall fitness. Another study indicated that aerobic exercise slightly outperformed circuit training in enhancing balance. Balance training, another option in this trial, can also help, though improvements are typically modest. Some evidence suggests it can aid in multitasking and balance. Both exercise types appear beneficial, but aerobic training might provide more significant advantages for those with cerebellar ataxia.13567
Are You a Good Fit for This Trial?
This trial is for individuals with Spinocerebellar Ataxias and related conditions who can perform physical exercises. The study aims to understand if exercise can improve certain brain-related learning processes.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Participants undergo baseline assessments including eyeblink conditioning using BlinkLab and other secondary outcome measures
Treatment
Participants are randomized to either home balance or aerobic training for 3 months, with weekly check-ins
Post-Treatment Assessment
Participants undergo post-treatment assessments including eyeblink conditioning and secondary outcome measures
Follow-up
Participants are monitored for changes in eyeblink conditioning and ataxia symptoms
What Are the Treatments Tested in This Trial?
Interventions
- Aerobic Training
- Balance Training
Find a Clinic Near You
Who Is Running the Clinical Trial?
Columbia University
Lead Sponsor