Quercetin for Coronary Artery Disease
(Q-CABG Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are taking quinolone antibiotics or quercetin supplements.
What evidence supports the effectiveness of the treatment Quercetin for Coronary Artery Disease?
Research suggests that quercetin, a natural compound found in many fruits and vegetables, has antioxidant and anti-inflammatory properties that may help manage conditions like atherosclerosis (a disease where plaque builds up in the arteries). While quercetin significantly increases its levels in the blood, studies have not shown it to directly affect heart disease risk factors in healthy individuals.12345
Is quercetin safe for human use?
How is the drug quercetin unique in treating coronary artery disease?
Quercetin is unique because it has antioxidant and anti-inflammatory properties that help protect the heart by improving blood flow, reducing heart rhythm issues, and limiting heart damage during a heart attack. It also helps maintain the integrity of blood vessels, which can prevent blood clots and improve overall heart function.311121314
What is the purpose of this trial?
This trial is testing quercetin, a natural substance found in fruits and vegetables, to see if it can reduce inflammation and slow down aging cells in patients undergoing heart bypass surgery. Patients will take quercetin starting before their surgery and continue for a short period afterward. The study will measure inflammation and cell health through blood samples. Quercetin is known for its antioxidant, anti-inflammatory, and cardio-protective properties.
Research Team
Michel Carrier, MD
Principal Investigator
Montreal Heart Institute
Eligibility Criteria
This trial is for adults who've had a heart attack in the last 30 days or have stable angina, awaiting coronary artery bypass surgery. They must speak French or English and consent to participate. Excluded are those without recent heart attacks, with infections, severe kidney/liver disease, estrogen-dependent tumor history, flavonoid intolerance, or taking certain medications.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Pre-surgery Treatment
Participants receive quercetin or placebo starting 2 days before surgery
Surgery and Immediate Post-surgery
Participants undergo coronary artery by-pass graft surgery and receive treatment during hospitalization
Follow-up
Participants are monitored for health status and changes post-surgery
Treatment Details
Interventions
- Quercetin
Quercetin is already approved in United States for the following indications:
- Herbal Supplementation
- Nonbacterial Chronic Prostatitis
- Interstitial Cystitis
Find a Clinic Near You
Who Is Running the Clinical Trial?
Montreal Heart Institute
Lead Sponsor