500 Participants Needed

MRI for Breast Cancer Diagnosis

JS
Overseen ByJocelyn Steffan
Age: 18+
Sex: Female
Trial Phase: Academic
Sponsor: Stanford University
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Approved in 1 JurisdictionThis treatment is already approved in other countries

What You Need to Know Before You Apply

What is the purpose of this trial?

To compare magnetic resonance imaging (MRI) with more well established diagnostic imaging techniques to determine which method best finds and defines breast cancer.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It is best to discuss this with the trial coordinators or your doctor.

Is MRI safe for humans?

MRI (Magnetic Resonance Imaging) is generally considered safe for humans, but there are some concerns about false-positive results, which can lead to unnecessary stress and additional testing. Additionally, artifacts (distortions in the images) can occur, which may affect the accuracy of the diagnosis.12345

How does MRI differ from other treatments for breast cancer?

MRI for breast cancer is unique because it provides detailed images that help in diagnosing and planning treatment, especially in cases where other imaging methods are less effective, such as in dense breast tissue or when multiple tumors are present. It is not a treatment itself but a tool that aids in better surgical planning and assessing the effectiveness of treatments like chemotherapy.13678

What data supports the effectiveness of the treatment MRI for breast cancer diagnosis?

MRI is effective in providing detailed images of breast lesions, which helps in planning breast-conservation therapy and surgical management. It is particularly useful for women with dense breast tissue or those with discrepancies between mammography and ultrasound, leading to more accurate treatment decisions.79101112

Who Is on the Research Team?

BL

Bruce L Daniel

Principal Investigator

Stanford University

Are You a Good Fit for This Trial?

This trial is for women with suspicious breast lesions, either felt by touch or seen in mammograms within the last 3 months. It's also open to those who've had a lumpectomy and now have new abnormalities. Men, pregnant or breastfeeding women, individuals with certain metal implants, severe claustrophobia, or allergies to MRI contrast agents cannot participate.

Inclusion Criteria

I am a woman who has had a breast exam documented.
I have a lump in my breast or an abnormal mammogram.
You need to have had a mammogram within the last 3 months before the MR studies.
See 1 more

Exclusion Criteria

I cannot have an MRI due to a pacemaker, metal in my body, severe fear of tight spaces, pregnancy, breastfeeding, or similar reasons.
I've had an MRI with contrast or am allergic to MRI dye.
I am biologically male.
See 1 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Imaging

Participants undergo contrast-enhanced magnetic resonance imaging (MRI) using standard department of Radiology MRI screening procedures

Up to 90 minutes

Follow-up

Participants are monitored for safety and effectiveness after imaging

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • MRI
Trial Overview The study is testing how well magnetic resonance imaging (MRI) can identify and define breast cancer compared to established diagnostic methods like mammography.
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: Magnetic Resonance Imaging (MRI) of Breast CancerExperimental Treatment1 Intervention
Contrast-enhanced magnetic resonance imaging (MRI) using the standard department of Radiology MRI screening procedures. The duration of scanning may be variable, but will not exceed 90 minutes.

Find a Clinic Near You

Who Is Running the Clinical Trial?

Stanford University

Lead Sponsor

Trials
2,527
Recruited
17,430,000+

National Cancer Institute (NCI)

Collaborator

Trials
14,080
Recruited
41,180,000+

National Institutes of Health (NIH)

Collaborator

Trials
2,896
Recruited
8,053,000+

Published Research Related to This Trial

Breast MRI is a highly effective tool for diagnosing breast cancer, particularly in women with dense breast tissue or those with silicone implants, as it provides detailed images that help assess the extent of the disease.
The use of breast MRI can enhance surgical planning and management by accurately characterizing tumor size and location, which is crucial for optimizing treatments like lumpectomy and evaluating the effectiveness of chemotherapy and radiation therapy.
MRI in breast cancer diagnosis and treatment.Harms, SE.[2019]
In a study of 45 breast cancer patients and 35 benign tumor patients, key MRI indicators for diagnosing breast cancer were identified, including tumor edge features, time-signal intensity curve (TIC) types, and apparent diffusion coefficient (ADC) values at b=500 s/mm2.
The combination of conventional MRI, diffusion-weighted imaging (DWI), and dynamic contrast-enhanced MRI provided the best diagnostic approach, with magnetic resonance spectroscopy (MRS) serving as a useful supplementary tool for challenging cases.
[Optimization of diagnosis indicator selection and inspection plan by 3.0T MRI in breast cancer].Jiang, Z., Wang, Y., He, Z., et al.[2015]
Magnetic resonance imaging (MRI) has emerged as the most accurate noninvasive method for local staging of breast cancer, significantly improving the measurement of tumor size and detection of multicentric disease.
The enhanced accuracy of MRI in evaluating breast tumors can influence treatment selection and prognosis, potentially transforming how clinical trials for new cancer therapies are designed and assessed.
Magnetic resonance imaging in breast cancer staging.Davis, PL., McCarty, KS.[2019]

Citations

MRI in breast cancer diagnosis and treatment. [2019]
[Optimization of diagnosis indicator selection and inspection plan by 3.0T MRI in breast cancer]. [2015]
Magnetic resonance imaging in breast cancer staging. [2019]
Role of magnetic resonance imaging in managing selected women with newly diagnosed breast cancer. [2010]
Magnetic resonance imaging for primary breast cancer management: current role and new applications. [2019]
Breast MRI for cancer detection and characterization: a review of evidence-based clinical applications. [2008]
Time-Related Changes in Yield and Harms of Screening Breast Magnetic Resonance Imaging. [2015]
Sixteen-Year Institutional Review of Magnetic Resonance Imaging-Guided Breast Biopsies: Trends in Histologic Diagnoses With Radiologic Correlation. [2023]
Breast MRI artefacts: evaluation and solutions in 630 consecutive patients. [2015]
Prevalence and influencing factors for artifact development in breast MRI-derived maximum intensity projections. [2023]
MRI in the detection and management of breast cancer. [2007]
12.United Statespubmed.ncbi.nlm.nih.gov
Magnetic resonance imaging of breast cancer: clinical indications and breast MRI reporting system. [2019]
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top
Terms of ServiceยทPrivacy PolicyยทCookiesยทSecurity