Topical Anesthetics for Lentigo
Trial Summary
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are taking a class I anti-arrhythmic medication.
What data supports the effectiveness of the drug lidocaine 2.5%/prilocaine 2.5% topical anesthetic and lidocaine 7%/tetracaine 7% topical anesthetic for treating lentigo?
Research shows that lidocaine/tetracaine cream is effective in reducing pain during dermatologic procedures, making it a promising option for similar skin treatments. The combination of lidocaine and tetracaine has been found to provide effective pain relief with mild side effects, which could be beneficial for treating lentigo.12345
Is the lidocaine/tetracaine topical anesthetic safe for use in humans?
How does the topical anesthetic treatment for lentigo differ from other treatments?
The topical anesthetic treatment for lentigo is unique because it involves the application of anesthetic creams like lidocaine and prilocaine, which are typically used for numbing the skin before minor procedures. This approach is novel for lentigo as it focuses on providing local anesthesia to the skin, potentially making the treatment more comfortable compared to other methods that may not address pain management directly.12367
What is the purpose of this trial?
This study will conduct a split-face and -body randomized control trial to compare lidocaine 2.5%/prilocaine 2.5% topical anesthetic (LPTA), lidocaine 7%/tetracaine 7% topical anesthetic (LTTA), and placebo vechicle (PV) on patients' pain perceptions with Q-switched 532nm laser for the treatment of lentigines and/or photorejuvenation.Subjects will fill out a pain score on a visual analog scale (VAS) with 0 being no pain and 10 being most pain after each treatment area is completed.
Research Team
Murad Alam, MD
Principal Investigator
Northwestern University
Eligibility Criteria
This trial is for women aged 25-65 with skin types I-III who have moderate lentigines or photodamage and want laser treatment. They must be in good health, able to consent, and not pregnant. Exclusions include certain medical conditions, recent facial treatments, allergies to anesthetics, chronic pain conditions, liver/kidney disease, or tanned skin.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive a single pass of the Q-switched 532nm laser after application of topical anesthetics or placebo
Follow-up
Participants are monitored for pain perception using a visual analog scale after treatment
Treatment Details
Interventions
- lidocaine 2.5%/prilocaine 2.5% topical anesthetic
- lidocaine 7%/tetracaine 7% topical anesthetic
- placebo vehicle
Find a Clinic Near You
Who Is Running the Clinical Trial?
Northwestern University
Lead Sponsor