← Back to Search

EEG Monitoring for Anesthesia in Aging

N/A

Waitlist Available

Led By Patrick L. Purdon, PhD

Research Sponsored by Massachusetts General Hospital

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Candidates scheduled for open or laparoscopic general surgical procedures under general anesthesia

American Society of Anesthesiologists (ASA) physical status classification of I, II or III

Timeline

Screening 3 weeks

Treatment Varies

Follow Up on postoperative day 1

Awards & highlights

Study Summary

This trial is exploring whether monitoring brain waves could help anesthesiologists deliver anesthesia more precisely, specifically in elderly patients.

Who is the study for?

This trial is for people aged 65 or older who are fluent in English and scheduled for surgery under general anesthesia. They must be generally healthy (ASA I-III) with no cognitive impairment, dementia, severe obesity, MRI contraindications like metal implants, or a history of significant neurological or psychiatric conditions.Check my eligibility

What is being tested?

The study is looking at how brain wave patterns during anesthesia (alpha oscillation dynamics) relate to brain images and aging. Participants will have their EEG monitored during surgery to see if these signals can predict changes in the brain associated with getting older.See study design

What are the potential side effects?

Since this trial involves standard procedures already used in surgeries (EEG monitoring and MRI), side effects are minimal but may include discomfort from wearing the EEG cap or lying still for an MRI scan.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am scheduled for surgery under general anesthesia.

Select...

My overall health is good to moderately impaired.

Select...

I am 65 years old or older.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ one week before the surgery and postoperative day 7

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~one week before the surgery and postoperative day 7

This trial's timeline: 3 weeks for screening, Varies for treatment, and one week before the surgery and postoperative day 7 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Intraoperative Burst Suppression Time

Postoperative Cognitive Decline

Postoperative Delirium Incidence

Trial Design

2Treatment groups

Active Control

Group I: Treatment GroupActive Control1 Intervention

Anesthesiologists in the treatment group use the unprocessed EEG waveforms and EEG spectrogram to maintain appropriate levels of unconsciousness for general anesthesia while avoiding burst suppression.

Group II: Control GroupActive Control1 Intervention

Anesthesiologists managing patients assigned to the control group will manage each anesthetic based on their clinical judgment, using standard monitoring required by American Society of Anesthesiologists (ASA), which include cardiac and respiratory monitoring, but not EEG monitoring.

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

Massachusetts General HospitalLead Sponsor

2,928 Previous Clinical Trials

13,198,331 Total Patients Enrolled

12 Trials studying Aging

1,131 Patients Enrolled for Aging

Patrick L. Purdon, PhDPrincipal InvestigatorMassachusetts General Hospital

Media Library

EEG-Guided Administration of General Anesthesia Clinical Trial Eligibility Overview. Trial Name: NCT03442179 — N/A

Aging Research Study Groups: Treatment Group, Control Group

Aging Clinical Trial 2023: EEG-Guided Administration of General Anesthesia Highlights & Side Effects. Trial Name: NCT03442179 — N/A

EEG-Guided Administration of General Anesthesia 2023 Treatment Timeline for Medical Study. Trial Name: NCT03442179 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any available opportunities to join this research initiative?

"As per the records hosted on clinicaltrials.gov, this research unfortunately is no longer looking for participants as it was last updated in October 2019. Nevertheless, there remain 48 other investigations that are actively recruiting patients at this time."

Answered by AI

Recent research and studies

Annals of Internal MedicineJournal

3D-CAM: Derivation and Validation of a 3-minute Diagnostic Interview for Cam-defined Delirium

Marcantonio, Edward R., Long H. Ngo, Margaret O'Connor, Richard N. Jones, Paul K. Crane, Eran D. Metzger, and Sharon K. Inouye. 2014. “3D-CAM: Derivation and Validation of a 3-minute Diagnostic Interview for Cam-defined Delirium”. Annals of Internal Medicine. American College of Physicians. doi:10.7326/m14-0865.

New England Journal of MedicineJournal

General Anesthesia, Sleep, and Coma

Brown, Emery N., Ralph Lydic, and Nicholas D. Schiff. 2010. “General Anesthesia, Sleep, and Coma”. Edited by Robert S. Schwartz. New England Journal of Medicine. Massachusetts Medical Society. doi:10.1056/nejmra0808281.

AnesthesiologyJournal

Predictors of Cognitive Dysfunction After Major Noncardiac Surgery

Monk, Terri G., B Craig Weldon, Cyndi W. Garvan, Duane E. Dede, Maria T. van der Aa, Kenneth M. Heilman, and Joachim S. Gravenstein. 2008. “Predictors of Cognitive Dysfunction After Major Noncardiac Surgery”. Anesthesiology. Ovid Technologies (Wolters Kluwer Health). doi:10.1097/01.anes.0000296071.19434.1e.

British Journal of AnaesthesiaJournal