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Lidocaine/Tetracaine Ointment vs Lidocaine/Prilocaine Cream for Photoaging

Phase 2 & 3

Recruiting

Led By Elika Hoss

Research Sponsored by Mayo Clinic

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up after laser treatment, approximately 60 minutes

Awards & highlights

Study Summary

This trial compares two topical treatments for numbing skin before a nonablative laser procedure.

Who is the study for?

This trial is for adults in good health with mild to moderate facial photoaging, who are undergoing a specific laser treatment. Women must use birth control if of childbearing potential. Excluded are those with certain skin conditions, severe diseases, recent use of isotretinoin or steroids, allergies to the anesthetics used, and pregnant or breastfeeding women.Check my eligibility

What is being tested?

The study compares two topical anesthetics: lidocaine/tetracaine ointment without occlusion versus lidocaine/prilocaine cream with occlusion before nonablative laser procedures on the face. The goal is to see which one is more effective at numbing the skin.See study design

What are the potential side effects?

Potential side effects may include reactions at the application site such as redness, swelling, itching or discomfort; rare systemic effects could be related to absorption like dizziness or irregular heart rate.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ after laser treatment, approximately 60 minutes

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~after laser treatment, approximately 60 minutes

This trial's timeline: 3 weeks for screening, Varies for treatment, and after laser treatment, approximately 60 minutes for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Self-reported pain after laser treatment

Secondary outcome measures

Self-reported burning after laser treatment

Self-reported itching after laser treatment

Trial Design

2Treatment groups

Active Control

Group I: 2.5 g of lidocaine 23% / tetracaine 7% ointmentActive Control1 Intervention

Patients undergoing 1927 nm fractional thulium fiber laser treatment of the face for photodamage as part of normal clinical care will have randomly assigned half of the face applied with 2.5 g of lidocaine 23% / tetracaine 7% ointment without occlusion for 60 minutes.

Group II: 7.5 g lidocaine 2.5%/ prilocaine 2.5% creamActive Control1 Intervention

Patients undergoing 1927 nm fractional thulium fiber laser treatment of the face for photodamage as part of normal clinical care will have randomly assigned half of the face applied with 7.5 g lidocaine 2.5%/ prilocaine 2.5% cream with occlusion for 60 minutes.

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor

3,213 Previous Clinical Trials

3,766,979 Total Patients Enrolled

Elika HossPrincipal Investigator - Mayo Clinic

Mayo Clinic Arizona

University Of Arizona College Of Medicine (Medical School)

Media Library

2.5 g of lidocaine 23% / tetracaine 7% ointment Clinical Trial Eligibility Overview. Trial Name: NCT04523961 — Phase 2 & 3

Anesthetic Toxicity Research Study Groups: 2.5 g of lidocaine 23% / tetracaine 7% ointment, 7.5 g lidocaine 2.5%/ prilocaine 2.5% cream

Anesthetic Toxicity Clinical Trial 2023: 2.5 g of lidocaine 23% / tetracaine 7% ointment Highlights & Side Effects. Trial Name: NCT04523961 — Phase 2 & 3

2.5 g of lidocaine 23% / tetracaine 7% ointment 2023 Treatment Timeline for Medical Study. Trial Name: NCT04523961 — Phase 2 & 3

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many people are eligible to take part in this research?

"The information available on clinicaltrials.gov suggests that this research project is still actively looking for participants. The study was originally posted on January 1st, 2021 and was updated as recently as January 13th, 2022. So far, only 32 individuals have been enrolled at a single location."

Answered by AI

Are people still eligible to sign up for this experiment?

"This clinical trial is currently recruiting patients, according to the listing on clinicaltrials.gov. The trial was first posted on January 1, 2021 and was last updated on January 13, 2022."

Answered by AI

What are some of the benefits to using 2.5 g of lidocaine 23% / tetracaine 7% ointment?

"The recommended dosage for treating sciatica is 2.5 grams of lidocaine 23% / tetracaine 7% ointment. However, 2.5 grams of lidocaine 23% / tetracaine 7% ointment can also be used to alleviate symptoms for conditions such as cervical syndrome, minor burns, and transplantation."

Answered by AI

Are there any other recorded instances of using 2.5 g of lidocaine 23% / tetracaine 7% ointment?

"To date, 138 clinical trials have been established to research the efficacy of 2.5 g of lidocaine 23% / tetracaine 7% ointment. Of those, 34 are still active. Many of the 2.5 g of lidocaine 23% / tetracaine 7% ointment trials are based in Saskatoon, Saskatchewan, but there are 1086 total locations running these experiments."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Comparative Study of Two Topical Anesthetics Prior to Fractional Nonablative Laser Treatment of the Face

Elika Hoss, MD 2021. "Comparative Study of Two Topical Anesthetics Prior to Fractional Nonablative Laser Treatment of the Face". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04523961.

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