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General Anesthetic

ECT with Etomidate for Depression

Phase 4
Waitlist Available
Led By Ian McIntyre, MD, MSc
Research Sponsored by University of Manitoba
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up approximately one week prior to, and at 2, 4 and 8 weeks post ect
Awards & highlights

Study Summary

This is a randomized controlled study assessing the effect of pre-emptive hyperventilation on ECT seizure duration, cerebral desaturation and remission of depressive symptoms in patients with Major Depressive Disorder. Comparison of etomidate and ketamine on remission of depressive symptoms with and without pre-emptive hyperventilation will also be studied.

Eligible Conditions
  • Depression

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~approximately one week prior to, and at 2, 4 and 8 weeks post ect
This trial's timeline: 3 weeks for screening, Varies for treatment, and approximately one week prior to, and at 2, 4 and 8 weeks post ect for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
ECT-induced seizure duration (seconds)
Electroencephalography
Secondary outcome measures
Changes in cerebral metabolism assessed by cerebral saturation (%)
Duration of stay in post-anesthesia care unit (hours)
Effect on blood pressure
+5 more

Trial Design

4Treatment groups
Active Control
Group I: ECT with EtomidateActive Control2 Interventions
Immediately prior to ECT study patients will be administered intravenous etomidate for anesthesia at a dose of 0.3 mg/kg given as a bolus dose.
Group II: ECT with KetamineActive Control2 Interventions
Immediately prior to ECT study patients will be administered intravenous ketamine for anesthesia at a dose of 0.5 -1.0 mg/kg given as a bolus dose.
Group III: ECT with Etomidate and HyperventilationActive Control3 Interventions
Immediately prior to ECT study patients will be administered intravenous etomidate for anesthesia at a dose of 0.3 mg/kg given as a bolus dose. Hyperventilation will be administered (20 breaths in 30 seconds) by face mask immediately prior to ECT.
Group IV: ECT with Ketamine and HyperventilationActive Control3 Interventions
Immediately prior to ECT study patients will be administered intravenous ketamine for anesthesia at a dose of 0.5 -1.0 mg/kg given as a bolus dose. Hyperventilation will be administered (20 breaths in 30 seconds) by face mask immediately prior to ECT.

Find a Location

Who is running the clinical trial?

University of ManitobaLead Sponsor
594 Previous Clinical Trials
199,394 Total Patients Enrolled
16 Trials studying Depression
1,213 Patients Enrolled for Depression
Ian McIntyre, MD, MScPrincipal InvestigatorUniversity of Manitoba
Michael Harrington, MDPrincipal InvestigatorUniversity of Manitoba

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
Psychiatry ResearchJournal
Rapid Antidepressant Effects of Repeated Doses of Ketamine Compared with Electroconvulsive Therapy in Hospitalized Patients with Major Depressive Disorder
Ghasemi, Mehdi, Mohammad H. Kazemi, Abolghasem Yoosefi, Abbas Ghasemi, Pedram Paragomi, Homayoun Amini, and Mohammad H. Afzali. 2014. “Rapid Antidepressant Effects of Repeated Doses of Ketamine Compared with Electroconvulsive Therapy in Hospitalized Patients with Major Depressive Disorder”. Psychiatry Research. Elsevier BV. doi:10.1016/j.psychres.2013.12.008.
clinicaltrials.govStudy
Hyperventilation Combined With Etomidate or Ketamine Anesthesia in ECT Treatment of Major Depression
2016. "Hyperventilation Combined With Etomidate or Ketamine Anesthesia in ECT Treatment of Major Depression". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02924090.
All > Anesthesia
~6 spots leftby Apr 2025
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