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EEG guided protocol for Delirium (ENGAGES Trial)

N/A
Waitlist Available
Led By Michael S. Avidan, MBBCh, FCASA
Research Sponsored by Washington University School of Medicine
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 year
Awards & highlights

ENGAGES Trial Summary

This study aims to determine whether, compared with usual anesthetic care, an electroencephalography-guided anesthesia protocol is effective at preventing postoperative delirium and its downstream effects, and improving postoperative patient reported health-related quality of life.

ENGAGES Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Number of Participants With Delirium
Secondary outcome measures
Health Related Quality of Life
Postoperative Falls
Other outcome measures
Agreements Among the FAM-CAM, Researchers' Delirium Assessments and Patient Perceptions
Clinically Relevant Outcomes Associated With Delirium
Collaborations With Other Studies
+10 more

ENGAGES Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: EEG guided protocolExperimental Treatment1 Intervention
Participants will have a pragmatic EEG-guided anesthetic protocol during their surgery. Practitioners will modify administration of anesthesia in an attempt to limit the occurrence of EEG burst suppression or persistent suppression.
Group II: Control ArmActive Control1 Intervention
Participants will have the standard anesthetic protocol.

Find a Location

Who is running the clinical trial?

Washington University School of MedicineLead Sponsor
1,938 Previous Clinical Trials
2,296,520 Total Patients Enrolled
7 Trials studying Delirium
75,228 Patients Enrolled for Delirium
National Institute on Aging (NIA)NIH
1,676 Previous Clinical Trials
28,020,099 Total Patients Enrolled
35 Trials studying Delirium
37,225 Patients Enrolled for Delirium
Sharon Inouye, MDStudy DirectorHebrew Rehabilitation Center

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
JamaJournal
Effect of Electroencephalography-guided Anesthetic Administration on Postoperative Delirium Among Older Adults Undergoing Major Surgery
Wildes, Troy S., Angela M. Mickle, Arbi Ben Abdallah, Hannah R. Maybrier, Jordan Oberhaus, Thaddeus P. Budelier, Alex Kronzer, et al.. 2019. “Effect of Electroencephalography-guided Anesthetic Administration on Postoperative Delirium Among Older Adults Undergoing Major Surgery”. Jama. American Medical Association (AMA). doi:10.1001/jama.2018.22005.
clinicaltrials.govStudy
Electroencephalography Guidance of Anesthesia
Michael Avidan 2015. "Electroencephalography Guidance of Anesthesia". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02241655.
All > Anesthesia
~135 spots leftby May 2025
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