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Opioid

methadone group for Long QT Syndrome

Phase 4
Recruiting
Led By Glenn S Murphy, MD
Research Sponsored by NorthShore University HealthSystem
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
All patients presenting for elective surgical cases requiring general anesthesia and associated with moderate-to-severe postoperative pain will be eligible for enrollment.
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 30 minutes after post anesthesia care unit admission
Awards & highlights

Study Summary

This study is evaluating whether a drug called methadone may help reduce the risk of a potentially lethal heart rhythm problem in patients who have undergone surgery.

Eligible Conditions
  • Long QT Syndrome

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~30 minutes after postanesthesia care unit admission
This trial's timeline: 3 weeks for screening, Varies for treatment, and 30 minutes after postanesthesia care unit admission for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
QT prolongation on the EKG 30 minutes after postanesthesia care unit admission
Secondary outcome measures
Level of pain on a 0-10 scale on the morning of postoperative day one
Level of pain on on a 0-10 scale 30 minutes after postanesthesia care unit admission
QT prolongation on the EKG on the morning of postoperative day one

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: methadone groupActive Control1 Intervention
Patients in this group will receive a syringe of methadone at the induction of anesthesia and a syringe of saline at the end of anesthesia.
Group II: hydromorphone groupPlacebo Group1 Intervention
Patients in this group will receive a syringe of saline at induction of anesthesia and a syringe of hydromorphone at the end of anesthesia

Find a Location

Who is running the clinical trial?

NorthShore University HealthSystemLead Sponsor
132 Previous Clinical Trials
737,720 Total Patients Enrolled
Glenn S Murphy, MDPrincipal InvestigatorNorthShore University HealthSystem
8 Previous Clinical Trials
1,010 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Effect of Methadone and Hydromorphone on the QT Interval After Anesthesia and Surgery
Glenn Murphy 2018. "Effect of Methadone and Hydromorphone on the QT Interval After Anesthesia and Surgery". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03893734.
All > Anesthesia
~20 spots leftby Apr 2025
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