Local multimodal analgesia group for Ankle Fractures

Phase-Based Estimates
1
Effectiveness
1
Safety
University of Utah Orthopaedic Center, Salt Lake City, UT
Ankle Fractures+1 More
Local multimodal analgesia group - Drug
Eligibility
18+
All Sexes
Eligible conditions
Ankle Fractures

Study Summary

This study is evaluating whether regional anesthesia is more effective than local analgesia in reducing post-operative pain.

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Eligible Conditions

  • Ankle Fractures
  • Fractures, Bone

Treatment Effectiveness

Study Objectives

This trial is evaluating whether Local multimodal analgesia group will improve 1 primary outcome in patients with Ankle Fractures. Measurement will happen over the course of 24-hour post-operative.

24-hour post-operative
Visual Analog Scale (VAS) pain

Trial Safety

Trial Design

2 Treatment Groups

Regional anesthesia group
Local multimodal analgesia group

This trial requires 200 total participants across 2 different treatment groups

This trial involves 2 different treatments. Local Multimodal Analgesia Group is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase < 1 and are in the first stage of evaluation with people.

Local multimodal analgesia group
Drug
Local multimodal analgesia composition will include 5mg of morphine, 500 mg of epinephrine, 15mg of ketorolac, and 20mg of bupivacaine.
Regional anesthesia group
Drug
Standard single-shot anesthesia consists of bupivacaine 0.25% with epinephrine 1:400,000.

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 24-hour post-operative
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 24-hour post-operative for reporting.

Who is running the study

Principal Investigator
J. H.
Justin Haller, Principle Investigator
University of Utah

Closest Location

University of Utah Orthopaedic Center - Salt Lake City, UT

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 5 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
people can apply People who speak English or Spanish can apply. show original
isolated rotational ankle fracture
A surgical intervention is needed. show original
provide informed consent
able to communicate with the research team via email or phone

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What causes ankle fractures?

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The ankle may be fractured by trauma or accidental fall of the foot, followed by hyperextension and external rotation in an attempt to get the ankle into its correct position. A displaced lateral malleolus fractures more easily owing to the bony architecture of the ankle. If one of the malleoli is fractured, this may cause disruption of the circulation, requiring urgent treatment.

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Can ankle fractures be cured?

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Fractures of the medial malleolus are rare, and patients are less likely to develop persistent arthritis than those who do not have an initial injury. Findings from a recent study support the theory that ankle fracture can be a manifestation of a medical condition and not a specific injury.

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What are common treatments for ankle fractures?

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For a relatively mild type of ankle fracture, the ankle is immobilized for at least a week following surgery. In the treatment of more severe types of injuries, such as high energy trauma or the open type, it is recommended to immobilize the ankle for 2–4 weeks. After this, the ankle is gradually rehabilitated in a gradual exercise program that involves progressively increasing mobility. Treatment is often discontinued when a satisfactory functional recovery has been reached through a functional assessment. The treatment of a displaced ankle fracture involves some minor surgical procedures such as reduction and fixation of the fracture, and the application of an internal splint to immobilize and stabilize the fractured bones when they are healing.

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What are the signs of ankle fractures?

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Ankle fractures can be considered to be the third most disabling musculoskeletal injury in the United Kingdom (25%). We conclude that an ankle trauma is not an uncommon lesion, especially for patients who do not have a fracture or malunion. We suggest that all trauma patients should have an X-ray of the ankle to make a proper diagnosis.

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How many people get ankle fractures a year in the United States?

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Around 9.5 million ankle fractures are diagnosed each year in the United States. Female patients are more susceptible to sustaining an ankle fracture compared with males.

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What is ankle fractures?

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Ankle fractures, especially with or without soft tissue injury, can lead to complications such as infections. Most patients could be treated by closed reduction and casting. There will be no need for operation. A high index of suspicion is important in diagnosing the ankle fractures.

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What does local multimodal analgesia group usually treat?

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The local multimodal analgesia group treated a wide spectrum of conditions. As expected, the knee and ankle osteodesis groups were the most frequently studied in both studies. The local multimodal analgesia group is the common framework for all the above-mentioned procedures. We strongly believe that the local multimodal analgesia group is the most common framework for any surgical orthopedic practice which uses local anesthesia. At present, we can speculate that many of the patients who have procedures and procedures requiring local anesthesia could be managed by a local multimodal analgesia team (e.g.

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What is the latest research for ankle fractures?

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Most recent studies point to positive results that support a more conservative approach to the management of post-high-energy ankle fractures. While these conclusions have been in place for some time, many experts still follow the traditional view of operative management for open wedge fractures, a technique that has been adopted for much longer by the general public than by the medical community.

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What is local multimodal analgesia group?

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In this series, local multimodal analgesia did not appear to increase risk of fracture in ankle fractures. At one hour after discharge from the hospital, patients reported using the local regimen the most frequently among both patients and staff. There was no correlation between the use of the local regimen and the occurrence of a fracture as well as hospital or long term follow up. As with the ankle, the local multimodal analgesia does not appear to increase risk for fracture; however, we advocate for randomized controlled trials of local analgesia use and fracture in the ankle.

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Is local multimodal analgesia group safe for people?

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Results from a recent clinical trial, multimodal analgesia was generally safe and can be well tolerated by patients with ankle fractures for at least 24 hours after surgery when it is used routinely.

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Has local multimodal analgesia group proven to be more effective than a placebo?

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In conclusion, the present work suggests that a local multimodal analgesia program could be more effective than a placebo in terms of improving analgesic efficiency and reducing pain on the first day after the ankle fracture. We believe that this program could also be effective for postoperative pain management.

Unverified Answer

Does local multimodal analgesia group improve quality of life for those with ankle fractures?

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A multimodal analgesia programme was shown to be an effective and safe treatment in patients undergoing operative management of ankle fractures. The benefits of the programme, and the potential risks of the programme, were not explained by differences in other quality of life outcomes.

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