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Brachytherapy

Interstitial Radiation Therapy for Kidney Cancer

Phase 1 & 2
Recruiting
Led By Albert J Chang
Research Sponsored by Jonsson Comprehensive Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Good performance status (Eastern Cooperative Oncology Group [ECOG]) < 2
No definitive evidence of locally advanced (nodal or tumor thrombus) or distant (metastatic) disease
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at 1 year
Awards & highlights

Study Summary

This trial is testing a new cancer treatment called interstitial brachytherapy to see if it is effective and has limited side effects.

Who is the study for?
This trial is for adults with kidney cancer that's too large or unsuitable for surgery or ablation. They must not be candidates for curative surgery, have a tumor size of 4-10 cm without evidence of advanced disease, and have normal liver function tests. Women must test negative for pregnancy, and all participants need good blood counts and kidney function.Check my eligibility
What is being tested?
The study is testing interstitial brachytherapy—a type of internal radiation therapy—on patients with large kidney tumors that can't be removed surgically. The goal is to see if this treatment can limit tumor growth and potentially shrink the cancer enough to lower the risk of it spreading.See study design
What are the potential side effects?
Possible side effects include localized pain, swelling at the treatment site, bleeding, infection risk from invasive procedure, fatigue due to radiation exposure, potential damage to surrounding tissues or organs near the treated area.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I can do most of my daily activities without help.
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My cancer has not spread to nearby lymph nodes or distant parts of my body.
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I am a woman who can have children and my pregnancy test before starting therapy was negative.
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My cancer can be treated with brachytherapy according to my radiation oncologist.
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I cannot or do not want to have surgery to cure my condition.
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I have not received any systemic treatment for kidney cancer.
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My tumor is mostly solid.
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My kidney cancer was confirmed through a biopsy.
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My kidney tumor can be treated with a special type of radiation.
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I have chosen to receive internal radiation therapy for my kidney cancer.
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My cancer cannot be treated with targeted destruction methods.
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My tumor is between 4 and 10 cm in size.
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My lesion has been growing for over 6 months and is expected to grow more than 4mm a year.
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My immune system is healthy.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at 1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and at 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Dose limiting toxicity (DLT)
One year (12-month) linear growth rate

Trial Design

1Treatment groups
Experimental Treatment
Group I: Treatment (interstitial brachytherapy)Experimental Treatment1 Intervention
Patients undergo interstitial brachytherapy for 1-2 fractions in the absence of disease progression or unacceptable toxicity. Patients who undergo 2 fractions may receive both fractions in the same day or on 2 separate days over 2 weeks.

Find a Location

Who is running the clinical trial?

Jonsson Comprehensive Cancer CenterLead Sponsor
358 Previous Clinical Trials
26,059 Total Patients Enrolled
Albert J ChangPrincipal InvestigatorUCLA / Jonsson Comprehensive Cancer Center
1 Previous Clinical Trials
9 Total Patients Enrolled

Media Library

Interstitial Radiation Therapy (Brachytherapy) Clinical Trial Eligibility Overview. Trial Name: NCT04473781 — Phase 1 & 2
Kidney Cancer Research Study Groups: Treatment (interstitial brachytherapy)
Kidney Cancer Clinical Trial 2023: Interstitial Radiation Therapy Highlights & Side Effects. Trial Name: NCT04473781 — Phase 1 & 2
Interstitial Radiation Therapy (Brachytherapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04473781 — Phase 1 & 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many people are currently taking part in this experiment?

"That is correct. The website clinicaltrials.gov indicates that this study, which was created on 16 July 2020 and last updated 18 July 2020, is currently seeking patients. In total, they need 17 individuals at a single location."

Answered by AI

Are there any positions available in this clinical trial for new patients?

"That is correct, the information available on clinicaltrials.gov indicates that this trial is still recruiting patients. The study was originally posted on July 16th, 2020 and has since been updated on July 18th, 2022. Currently, there is only 1 site for recruitment but the study is looking for a total of 17 participants."

Answered by AI
~1 spots leftby Jun 2024