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NMDA Receptor Antagonist

Ketamine for Surgery

Phase 4
Waitlist Available
Led By Boris D Heifets, MD, PhD
Research Sponsored by Stanford University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up post-intervention days 1, 2, 3, 5, 7 and 14
Awards & highlights

Study Summary

This trial is testing whether ketamine can help relieve depression symptoms in people undergoing non-cardiac surgery.

Eligible Conditions
  • Depression
  • Surgery
  • Orthopedic Disorders

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~post-intervention days 1, 2, 3, 5, 7 and 14
This trial's timeline: 3 weeks for screening, Varies for treatment, and post-intervention days 1, 2, 3, 5, 7 and 14 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Montgomery-Asberg Depression Rating Scale (MADRS) Score
Secondary outcome measures
Brief Pain Inventory Pain Intensity Scale Score
Brief Pain Inventory Pain Interference Scale Score
Cumulative Opioid Use
+4 more
Other outcome measures
Hospital length of stay
Opioid consumption
Pain at surgical site: scale of 0-10
+4 more

Trial Design

3Treatment groups
Experimental Treatment
Placebo Group
Group I: Open label ketamineExperimental Treatment1 Intervention
Patients will receive an intravenous ketamine infusion during surgery.
Group II: Double blind ketamineExperimental Treatment1 Intervention
Patients will receive an intravenous ketamine infusion during surgery.
Group III: Double blind placeboPlacebo Group1 Intervention
Participants will receive placebo (normal saline infusion) during surgery.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Ketamine
2011
Completed Phase 4
~1090

Find a Location

Who is running the clinical trial?

Stanford UniversityLead Sponsor
2,394 Previous Clinical Trials
17,341,565 Total Patients Enrolled
6 Trials studying Surgery
932 Patients Enrolled for Surgery
Boris D Heifets, MD, PhDPrincipal InvestigatorStanford University

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who else is applying?

What state do they live in?
California
How old are they?
18 - 65
What site did they apply to?
Stanford University
What portion of applicants met pre-screening criteria?
Met criteria
Did not meet criteria
Recent research and studies
clinicaltrials.govStudy
Intraoperative Ketamine Versus Saline in Depressed Patients Undergoing Anesthesia for Non-cardiac Surgery
Boris D. Heifets 2019. "Intraoperative Ketamine Versus Saline in Depressed Patients Undergoing Anesthesia for Non-cardiac Surgery". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03861988.
All > Anesthesia
~8 spots leftby Apr 2025
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