← Back to Search

Opioid Analgesic

TAP Catheter vs. Spinal Morphine for Post-Cesarean Pain

N/A

Waitlist Available

Research Sponsored by Stamford Anesthesiology Services, PC

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patients age 18 - 45 years of age undergoing cesarean section under spinal anesthesia

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 48 hours

Awards & highlights

Study Summary

This trial is testing whether a long-acting local anesthetic infusion is better than spinal morphine for post-cesarean recovery, in terms of nausea, pruritus, and pain.

Who is the study for?

This trial is for English-reading women aged 18-45 undergoing a cesarean section with spinal anesthesia. It's not suitable for those lacking mental capacity to consent, needing a translator, having additional procedures, diabetes or chronic steroid use history, recent opioid use, or allergies to local anesthetics.Check my eligibility

What is being tested?

The study compares the effectiveness of TAP catheter infusions using long-acting local anesthetic against intrathecal morphine in managing postoperative pain after cesarean sections. The goal is to see if TAP catheters can improve recovery quality by reducing side effects like nausea and itching.See study design

What are the potential side effects?

Intrathecal morphine may cause significant nausea and itching. While the TAP catheter aims to reduce these issues by delivering local anesthetic directly near nerves around the surgical site, potential side effects are not detailed but could include discomfort at the infusion site.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am between 18 and 45 years old and will have a cesarean section with spinal anesthesia.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 48 hours

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~48 hours

This trial's timeline: 3 weeks for screening, Varies for treatment, and 48 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Quality of recovery after cesarean section

Secondary outcome measures

Incidence of nausea/vomiting

incidence and severity of pruritus

overall oral narcotic use during the 48 hours post-operatively

Trial Design

2Treatment groups

Active Control

Group I: TAP catheterActive Control1 Intervention

Indwelling TAP catheter placed at the end of c-section. It will be dosed with 20ml of Ropivacaine 0.5% at that time. Double lumen OnQ C-block pump containing 700 ml of the Ropivacaine 0.2% will be attached to the TAP catheters in the recovery room. The catheters will run at 7cc/hr/side for 50 hrs.

Group II: intrathecal morphineActive Control1 Intervention

0.3 mg of intrathecal morphine

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Stamford Anesthesiology Services, PCLead Sponsor

1 Previous Clinical Trials

100 Total Patients Enrolled

I-FlowIndustry Sponsor

6 Previous Clinical Trials

382 Total Patients Enrolled

Media Library

Intrathecal Morphine (Opioid Analgesic) Clinical Trial Eligibility Overview. Trial Name: NCT01593280 — N/A

Adult Research Study Groups: TAP catheter, intrathecal morphine

Adult Clinical Trial 2023: Intrathecal Morphine Highlights & Side Effects. Trial Name: NCT01593280 — N/A

Intrathecal Morphine (Opioid Analgesic) 2023 Treatment Timeline for Medical Study. Trial Name: NCT01593280 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are elderly people excluded from the scope of this clinical trial?

"The requisite age to be part of this trial is 18-45. Those below the age of consent are eligible for 85 other studies, while those over 65 can look at 430 different options."

Answered by AI

Are my characteristics suitable for enrollment in this experiment?

"This research project is looking to include 80 individuals aged 18 through 45 who are birthing with a cesarean section in the context of spinal anesthesia."

Answered by AI

What is the enrollment capacity for this experiment?

"This clinical trial has momentarily ceased its recruitment process. The study was first listed on May 1st, 2012 and edited most recently on the 7th of that same month. If you are seeking alternative trials, there currently exist 514 human studies and 54 intrathecal morphine studies actively searching for patients at this time."

Answered by AI

Are participants being actively sought for the current experiment?

"Unfortunately, this trial is not currently accepting applicants. It was initially published on the 1st of May 2012 and updated most recently on the 7th of May 2012. Alternatively, there are 514 trials actively recruiting human participants and 54 studies for intrathecal morphine which are also looking for individuals to join their research projects."

Answered by AI

Are there any related investigations that have undertaken intrathecal morphine?

"Presently, there are 54 experiments involving intrathecal morphine in active development with 15 of them reaching Phase 3. Most trials for this drug are taking place within the state of Massachusetts, particularly Boston; however, 131 sites worldwide have begun hosting research into its efficacy."

Answered by AI

Recent research and studies

Anesthesia & AnalgesiaJournal

The Analgesic Efficacy of Transversus Abdominis Plane Block After Cesarean Delivery: A Randomized Controlled Trial

McDonnell, John G., Gerard Curley, John Carney, Aoife Benton, Joseph Costello, Chrisen H. Maharaj, and John G. Laffey. 2008. “The Analgesic Efficacy of Transversus Abdominis Plane Block After Cesarean Delivery: A Randomized Controlled Trial”. Anesthesia & Analgesia. Ovid Technologies (Wolters Kluwer Health). doi:10.1213/01.ane.0000290294.64090.f3.

International Journal of Obstetric AnesthesiaJournal

A Randomized Controlled Trial Comparing Intrathecal Morphine with Transversus Abdominis Plane Block for Post-cesarean Delivery Analgesia

Loane, H., R. Preston, M.J. Douglas, S. Massey, M. Papsdorf, and J. Tyler. 2012. “A Randomized Controlled Trial Comparing Intrathecal Morphine with Transversus Abdominis Plane Block for Post-cesarean Delivery Analgesia”. International Journal of Obstetric Anesthesia. Elsevier BV. doi:10.1016/j.ijoa.2012.02.005.

Journal of AnesthesiaJournal

Transversus Abdominis Plane Block Reduces Postoperative Pain Intensity and Analgesic Consumption in Elective Cesarean Delivery Under General Anesthesia

Eslamian, Laleh, Zorvan Jalili, Ashraf Jamal, Vajiheh Marsoosi, and Ali Movafegh. 2012. “Transversus Abdominis Plane Block Reduces Postoperative Pain Intensity and Analgesic Consumption in Elective Cesarean Delivery Under General Anesthesia”. Journal of Anesthesia. Springer Science and Business Media LLC. doi:10.1007/s00540-012-1336-3.

Anesthesia & AnalgesiaJournal