Ketorolac for Tonsillitis

Phase-Based Progress Estimates
University of Tennessee Health Science Center; St. Jude Children's Research Hospital, Memphis, TNTonsillitis+4 MoreKetorolac - Drug
2 - 18
All Sexes
What conditions do you have?

Study Summary

This trial will compare two types of anesthesia for tonsillectomy surgery, one with opioids and one without, to see if the opioid-free option is just as good.

Eligible Conditions
  • Tonsillitis
  • Opioid Use Disorder
  • Surgery
  • Sleep Disorders
  • Anesthesia

Treatment Effectiveness

Effectiveness Progress

3 of 3
This is further along than 93% of similar trials

Study Objectives

1 Primary · 6 Secondary · Reporting Duration: up to 2 years

up to 2 years
Bleeding prevalence
Frequency of non-artifactual percentage of oxygen saturation (SpO2)<90% (>30 seconds)
Frequency of readmission and of seeking unplanned medical attention (phone calls, office visits, ED visits)
Percentage of patients receiving rescue opioids
up to 30 minutes
Median Maximum Pain Score
Day 30
Family satisfaction with patient recovery based on seven-point Likert score
Frequency of nausea, vomiting, pruritis

Trial Safety

Safety Progress

3 of 3
This is further along than 85% of similar trials

Trial Design

2 Treatment Groups

Traditional Care Group (TCG)
1 of 2
Opioid-Free Group (OFG)
1 of 2

Active Control

Experimental Treatment

550 Total Participants · 2 Treatment Groups

Primary Treatment: Ketorolac · No Placebo Group · Phase 4

Opioid-Free Group (OFG)Experimental Group · 2 Interventions: Ketorolac, Dexmedetomidine · Intervention Types: Drug, Drug
Traditional Care Group (TCG)ActiveComparator Group · 2 Interventions: Morphine, Fentanyl · Intervention Types: Drug, Drug
First Studied
Drug Approval Stage
How many patients have taken this drug
FDA approved
FDA approved

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: up to 2 years

Who is running the clinical trial?

University of Tennessee Health Science CenterOTHER
48 Previous Clinical Trials
24,599 Total Patients Enrolled
University of TennesseeOTHER
185 Previous Clinical Trials
141,449 Total Patients Enrolled
Children's Hospital of PhiladelphiaLead Sponsor
661 Previous Clinical Trials
7,854,936 Total Patients Enrolled
University of PennsylvaniaOTHER
1,873 Previous Clinical Trials
41,146,250 Total Patients Enrolled
Tori Sutherland, MD,MPHPrincipal InvestigatorChildren's Hospital of Philadelphia
Anthony Sheyn, MD, FACSPrincipal InvestigatorUniversity of Tennessee

Eligibility Criteria

Age 2 - 18 · All Participants · 5 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:

Frequently Asked Questions

Is enrollment open to minors for this medical experiment?

"This particular medical research is open to minors between 2 and 18 years of age. There are 159 trials specifically for people in this demographic, while 633 studies concentrate on individuals over 65." - Anonymous Online Contributor

Unverified Answer

Are there other examinations that have been conducted concerning Ketorolac?

"Currently, there are 220 ongoing studies on ketorolac and 49 of them have entered Phase 3. With 425 recruiting sites across the United States, many of which in Boston Massachusetts, this medication is being heavily researched." - Anonymous Online Contributor

Unverified Answer

To what degree is Ketorolac a secure medication for individuals?

"The safety of Ketorolac has been clinically validated, thus it earned a score of 3." - Anonymous Online Contributor

Unverified Answer

How many participants is the maximum capacity for this clinical experiment?

"Affirmative, reveals that the trial is actively seeking participants. Initially posted on July 22nd 2020 and modified as recently as August 29th 2022, this medical research requires 550 individuals to be enrolled from two separate facilities." - Anonymous Online Contributor

Unverified Answer

Is eligibility for this trial open at the present time?

"Correct. Data held on suggests that recruitment for this trial, which was originally published on July 22nd 2020, is currently ongoing. Approximately 550 people need to be recruited from 2 distinct medical facilities." - Anonymous Online Contributor

Unverified Answer

For what medical conditions is Ketorolac commonly prescribed?

"Ketorolac is generally prescribed to reduce the effects of general anesthesia. In addition, it's also utilized in cases such as miosis disorder and intraocular lens replacement." - Anonymous Online Contributor

Unverified Answer

Could I fulfill the criteria for this experimental research?

"This medical research is seeking 550 pediatric patients between the ages of two and eighteen suffering from tonsillitis. To be eligible, participants must meet these conditions: Male or female with a maximum American Society of Anesthesiologists (ASA) physical classification score 3; post-menarche girls must present a negative pregnancy test result; undergo scheduled tonsillectomy/tonsillectomy in combination with adenoidectomy and/or ear tube placement at the Children's Hospital of Philadelphia (CHOP)'s main or ambulatory surgical centers." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.