Study Summary
This trial will test whether patients who have surgery on their temporomandibular joint (TMJ) recover better when they do not receive opioids during anesthesia.
Eligible Conditions
- Temporomandibular Joint Disorder (TMJ Disorder)
Treatment Effectiveness
Effectiveness Progress
Study Objectives
1 Primary · 6 Secondary · Reporting Duration: 48 hours postoperatively
48 hours postoperatively
Incidence of Opioid Related Adverse Effects
Percocet Use
Perioperative Opioid Use
Day 1
Length of Stay
Pain Satisfaction
Pain Score
Rescue Analgesia in the PACU
Trial Safety
Safety Progress
This is further along than 68% of similar trials
Trial Design
2 Treatment Groups
Standard Anesthesia
1 of 2
Opioid-free Anesthesia
1 of 2
Active Control
Experimental Treatment
60 Total Participants · 2 Treatment Groups
Primary Treatment: Dexmedetomidine / Ketamine / Lidocaine · No Placebo Group · Phase 2
Opioid-free Anesthesia
Drug
Experimental Group · 1 Intervention: Dexmedetomidine / Ketamine / Lidocaine · Intervention Types: DrugStandard AnesthesiaNoIntervention Group · 1 Intervention: Standard Anesthesia · Intervention Types:
Trial Logistics
Trial Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 48 hours postoperatively
Who is running the clinical trial?
Massachusetts General HospitalLead Sponsor
2,703 Previous Clinical Trials
30,853,100 Total Patients Enrolled
Jingping Wang, MDPrincipal InvestigatorMassachusetts General Hospital
Eligibility Criteria
Age 18 - 75 · All Participants · 4 Total Inclusion Criteria
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Conditions
Cancer Related
Treatments