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Dexmedetomidine / Ketamine / Lidocaine for Temporomandibular Joint Disorder

Phase 2
Recruiting
Led By Jingping Wang, MD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 48 hours postoperatively
Awards & highlights

Study Summary

This trial will test whether patients who have surgery on their temporomandibular joint (TMJ) recover better when they do not receive opioids during anesthesia.

Eligible Conditions
  • Temporomandibular Joint Disorder (TMJ Disorder)

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~48 hours postoperatively
This trial's timeline: 3 weeks for screening, Varies for treatment, and 48 hours postoperatively for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Pain Score
Secondary outcome measures
Incidence of Opioid Related Adverse Effects
Length of Stay
Pain Satisfaction
+3 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Opioid-free AnesthesiaExperimental Treatment1 Intervention
Patients in this arm will not receiving opioids but the total intravenous anesthetic during surgery. Patients in this group will receive an infusion of lidocaine, ketamine, or dexmedetomidine supplemented with other intravenous analgesics and intravenous and inhaled anesthetics.
Group II: Standard AnesthesiaActive Control1 Intervention
Patients in this arm will undergo the standard of care and receive opioids as part of their anesthetic regimen.

Find a Location

Who is running the clinical trial?

Massachusetts General HospitalLead Sponsor
2,929 Previous Clinical Trials
13,198,245 Total Patients Enrolled
Jingping Wang, MDPrincipal InvestigatorMassachusetts General Hospital

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Might I be eligible to participate in this research?

"This research is trying to understand how well a new medication works for people with temporomandibular joint disorders. To be included in the study, patients must between 18 and 75 years old. In total, the researchers need 60 participants."

Answered by AI

Can people with the qualification still join this research project?

"Yes, this is an ongoing trial that was first posted on June 18th, 2021 and updated most recently on July 14th, 2022. The study is currently enrolling 60 patients at a single site."

Answered by AI

How many individuals are participating in this clinical trial?

"That is correct, the website provides evidence that the trial is ongoing and looking for 60 individuals from a single location. The listing was created on 6/18/2021 with the most recent update being from 7/14/2022."

Answered by AI

Has the FDA acknowledged Dexmedetomidine / Ketamine / Lidocaine as a safe and effective medication?

"Given that this is a phase 2 trial, and therefore there is only some data supporting safety but no evidence of efficacy, our team has given Dexmedetomidine / Ketamine / Lidocaine a score of 2 in terms of safety."

Answered by AI

Does this trial have an age limit of twenty-five years or older?

"Patients that meet the age requirement of 18-75 years old are eligible for this particular study. There are 69 other trials targeting patients below 18 and 383 involving seniors above 65."

Answered by AI

To what purpose is the Dexmedetomidine / Ketamine / Lidocaine combination most often given to patients?

"This medication, which is typically given to patients with cervical syndrome, can also be used to mitigate the pain of minor burns, during general anesthesia, and for other procedures where anesthesia is needed."

Answered by AI

Are Dexmedetomidine / Ketamine / Lidocaine often used in medical research?

"There are currently 338 live clinical trials researching the combined effects of Dexmedetomidine, Ketamine, and Lidocaine. Out of these studies, 70 are in Phase 3. Additionally, while there are several clinical trials for Dexmedetomidine / Ketamine / Lidocaine located in Duarte, California specifically, there are 1,496 locations with active research on this topic."

Answered by AI

Who else is applying?

What state do they live in?
Mississippi
What portion of applicants met pre-screening criteria?
Did not meet criteria
How many prior treatments have patients received?
3+
Recent research and studies
clinicaltrials.govStudy
The Effect of Opioid-Free Anesthesia in TMJ Surgery
Jingping Wang, MD, Ph.D. 2021. "The Effect of Opioid-Free Anesthesia in TMJ Surgery". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04724759.
All > Anesthesia
~16 spots leftby Apr 2025
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