Clinical Trials in Nashville, TN

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Clinical Trials Clinical Trials in Nashville, TN

Reviewed by Michael Gill, B. Sc.

Image of Research Site 24 in Huntsville, United States.

Phase-Based Progress Estimates

Maintenance Phase - BLI5100 Low Dosefor Erosive Esophagitis

The objective of the Healing Phase of the study is to evaluate the safety and efficacy of up to 8 weeks of once daily oral administration of BLI5100 versus a PPI control in healing EE. The objective of the Maintenance Phase of the study is to evaluate the safety and efficacy of 24 weeks of once daily oral administration of BLI5100 (low or high dose) versus a PPI control in the maintenance of healed EE.

Research Site 24 (+25 Sites)Leah HollinsBraintree Laboratories

Image of University of California Los Angeles Medical Center in Los Angeles, United States.

Phase-Based Progress Estimates

PRO1184for erbB-2 Receptor

This study will test the safety, including side effects, and determine the characteristics of a drug called PRO1184 in participants with solid tumors. Participants will have solid tumor cancer that has spread through the body (metastatic) or cannot be removed with surgery (unresectable). This study will have two parts. Part A of the study will find out how much and how frequently PRO1184 should be given to participants. Part B will use the dose and schedule found in Part A to find out how safe PRO1184 is and if it works to treat solid tumor cancers.

University of California Los Angeles Medical Center (+9 Sites)ProfoundBio US Co.

Image of Sarah Cannon Research in Nashville, United States.

Phase-Based Progress Estimates

Dose Escalationfor Castration Resistant Prostatic Cancer

This trial is testing a new drug for prostate cancer that has spread and is resistant to hormone therapy. They will study how well the drug works and if it is safe.

Sarah Cannon ResearchJanux Therapeutics, MDJanux Therapeutics

Image of University of California, San Diego - Antiviral Research Center in San Diego, United States.

Phase-Based Progress Estimates

JYNNEOSfor Monkeypox

This trial will compare two lower doses of the MVA-BN vaccine given intradermally to the standard dose given subcutaneously in order to see if there is a non-inferior response in terms of humoral immunity.

University of California, San Diego - Antiviral Research Center (+15 Sites)

Image of Vanderbilt University Medical Center in Nashville, United States.

Phase-Based Progress Estimates

CSTI-500 10mgfor Royer Syndrome

The purpose of this Phase 1 study is to evaluate the pharmacokinetics (PK) and safety of a single dose of CSTI-500 10 mg in subjects with Prader-Willi syndrome (PWS) between 13 and 50 years of age with a genetically confirmed diagnosis of PWS.

Vanderbilt University Medical CenterItalo Biaggioni, MDConSynance Therapeutics

Image of Vanderbilt University Medical Center in Nashville, United States.

Phase-Based Progress Estimates

Muscle Stimulationfor Obstructive Sleep Apnea (OSA)

Polysomnography (PSG) and drug-induced sleep endoscopy (DISE) are widely used diagnostic studies for assessing obstructive sleep apnea (OSA) severity and collapse patterns of the upper airway anatomy during sleep. Hypoglossal nerve stimulation (HNS) therapy for obstructive sleep apnea suffers from variable response at the level of the soft palate. The Investigators propose a study examining the physiologic effect of ansa cervicalis stimulation (ACS) alone and in combination with HNS during PSG and DISE.

Vanderbilt University Medical CenterDavid T. Kent, MD

Image of Vanderbilt University Medical Center in Nashville, United States.

Phase-Based Progress Estimates

Plasma P-tau Risk Disclosurefor Alzheimer Disease

This trial is testing whether it is safe to tell people with mild cognitive impairment their risk of Alzheimer's based on their plasma levels of tau phosphorylated at threonine 181 (p-tau181).

Vanderbilt University Medical CenterCorey J Bolton, PsyD

Image of City of Hope ( City of Hope National Medical Center, City of Hope Medical Center ) in Duarte, United States.

Phase-Based Progress Estimates

Magrolimabfor Colorectal Cancer

This trial is testing a new drug for people with mCRC who have already tried other treatments. The goal is to see if it is safe and effective.

City of Hope ( City of Hope National Medical Center, City of Hope Medical Center ) (+6 Sites)Gilead Study DirectorGilead Sciences

Image of University of Alabama at Birmingham in Birmingham, United States.

Phase-Based Progress Estimates

Posoleucel (ALVR105)for Adenovirus Infections

Senior-friendly

This trial will test an allogeneic, multi-virus specific T cell therapy for six viral pathogens.

Senior-friendly

University of Alabama at Birmingham (+49 Sites)AlloVir

Image of Carolina Biooncology Institute in Huntersville, United States.

Phase-Based Progress Estimates

AU-007 Combined With Aldesleukin Given Concomitantlyfor Metastatic Cancers

This trial is testing a new drug, AU-007, to see if it is safe and effective in treating people with advanced solid tumors.

Carolina Biooncology Institute (+3 Sites)Aulos Bioscience, Inc.

Image of Children's Hospital of Alabama in Birmingham, United States.

Phase-Based Progress Estimates

Thoracoscopyfor Osteosarcoma

This trial compares the effect of open thoracic surgery to thoracoscopic surgery in treating patients with osteosarcoma that has spread to the lung.

Children's Hospital of Alabama (+99 Sites)John J Doski

Image of Children's Hospital Los Angeles in Los Angeles, United States.

Phase-Based Progress Estimates

Setrusumabfor Lobstein's Disease

This trial is testing a new drug, setrusumab, to see if it can reduce the rate of fractures in people with osteogenesis imperfecta (OI), a condition that causes weak bones.

Children's Hospital Los Angeles (+28 Sites)Ultragenyx Medical DirectorMereo BioPharma

Image of Tulane Cancer Center Clinic - Oncology in New Orleans, United States.

Phase-Based Progress Estimates

Tivozanibfor Carcinoma

FDA Approved Drug

This trial will be testing whether adding tivozanib to nivolumab will be more effective than tivozanib alone in treating advanced RCC.

FDA Approved Drug

Tulane Cancer Center Clinic - Oncology (+23 Sites)AVEO Pharmaceuticals, Inc.

Image of Accel Research Sites in DeLand, United States.

Phase-Based Progress Estimates

JNJ-40411813for Seizures

This trial is testing a new drug to see if it can help people with epilepsy who are already taking other medication. The trial will last for a while, and participants will be monitored for safety and efficacy.

Accel Research Sites (+6 Sites)Janssen Research & Development, LLC Clinical TrialJanssen Research & Development, LLC

Image of Alabama Oncology, Bruno Cancer Center in Birmingham, United States.

Phase-Based Progress Estimates

MRTX849for Colorectal Cancer

FDA Approved Drug

This trial is testing a new drug, MRTX849, to see if it is better than chemotherapy at treating colorectal cancer that has a KRAS G12C mutation.

FDA Approved Drug

Alabama Oncology, Bruno Cancer Center (+97 Sites)Andrew Chi, MD, Ph.DMirati Therapeutics Inc.

Image of Stanford University Medical Center in Stanford, United States.

Phase-Based Progress Estimates

Mavacamtenfor Cardiomyopathies

Waitlist Available

This trial will test if mavacamten can reduce the number of heart procedures in people with symptomatic obstructive hypertrophic cardiomyopathy who are eligible for the procedure based on current guidelines.

Waitlist Available

Stanford University Medical Center (+46 Sites)Bristol-Myers SquibbMyoKardia, Inc.

Image of Investigational Site Number 1240004 in Edmonton, Canada.

Phase-Based Progress Estimates

Isatuximab SAR650984for Neoplasms, Plasma Cell

FDA Approved Drug

This trial is testing a drug to see if it can help people with a certain type of cancer.

FDA Approved Drug

Investigational Site Number 1240004 (+7 Sites)Clinical Sciences & OperationsSanofi

Image of Sylvester Comprehensive Cancer Center, University of Miami Hospital and Clinics in Miami, United States.

Phase-Based Progress Estimates

RVU120(SEL120)for Preleukemia

This trial will test a new drug for leukemia and myelodysplastic syndrome to see if it is safe and effective.

Sylvester Comprehensive Cancer Center, University of Miami Hospital and Clinics (+4 Sites)Ryvu Therapeutics SA

Image of University of Alabama at Birmingham Cancer Center in Birmingham, United States.

Phase-Based Progress Estimates

Pembrolizumabfor Stage IIIB Uterine Corpus Cancer AJCC v8

FDA Approved Drug

This trial is studying the combination of pembrolizumab, paclitaxel, and carboplatin to treat endometrial cancer.

FDA Approved Drug

University of Alabama at Birmingham Cancer Center (+99 Sites)Ramez N Eskander

Image of UCLA Jonsson Comprehensive Cancer Center in Los Angeles, United States.

Phase-Based Progress Estimates

ARV-110for Prostate Cancer

This trial is testing a new cancer drug in men who have prostate cancer that has spread and progressed despite treatment with other drugs. The study will assess how well the new drug is tolerated and how safe it is.

UCLA Jonsson Comprehensive Cancer Center (+99 Sites)Arvinas Inc.

Image of Anchorage Associates in Radiation Medicine in Anchorage, United States.

Phase-Based Progress Estimates

Pembrolizumabfor Stage IIIB Lung Cancer AJCC v8

FDA Approved Drug

This trial is studying whether giving first-line pembrolizumab followed by pemetrexed and carboplatin with or without pembrolizumab works better in treating patients with advanced non-squamous non-small cell lung cancer.

FDA Approved Drug

Anchorage Associates in Radiation Medicine (+99 Sites)Hossein Borghaei

Image of Arizona Oncology Associates, PC - HOPE in Tucson, United States.

Phase-Based Progress Estimates

CPI-006for Sarcoma

Waitlist Available

FDA Approved Drug

This trial is testing a new cancer drug, CPI-006, alone and in combination with other drugs, to see if it is safe and effective in treating advanced cancer.

Waitlist Available

FDA Approved Drug

Arizona Oncology Associates, PC - HOPE (+25 Sites)S Mahabhashyam, MDCorvus Pharmaceuticals, Inc.

Image of University of Arizona Cancer Center-Orange Grove Campus in Tucson, United States.

Phase-Based Progress Estimates

Radiation Therapyfor Intracranial Meningioma

This trial compares radiation therapy with observation in treating patients with newly diagnosed grade II meningioma.

University of Arizona Cancer Center-Orange Grove Campus (+99 Sites)C. Leland Rogers, MD

Image of Florida Cancer Specialists - Sarasota in Sarasota, United States.

Phase-Based Progress Estimates

Phase Ib: Dose Escalationfor Melanoma

This is a first-in-human study to evaluate the safety, tolerability, pharmacokinetics (PK), and anti-tumor activity of RO7502175 when administered as a single agent and in combination with atezolizumab in adult participants with locally advanced or metastatic solid tumors, including non-small-cell lung cancer (NSCLC), head and neck squamous cell carcinoma (HNSCC), melanoma, triple-negative breast cancer (TNBC), esophageal cancer, gastric cancer, cervical cancer, urothelial carcinoma (UC), clear cell renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC). Participants will be enrolled in 2 stages: dose escalation and dose expansion.

Florida Cancer Specialists - Sarasota (+2 Sites)Genentech, Inc.

Image of Vanderbilt University Medical Center in Nashville, United States.

Phase-Based Progress Estimates

Volume Control Modefor Respiratory Failure

Landmark trials in critical care have demonstrated that, among critically ill adults receiving invasive mechanical ventilation, the use of low tidal volumes and low airway pressures prevents lung injury and improves patient outcomes. Limited evidence, however, informs the best method of mechanical ventilation to achieve these targets. To provide mechanical ventilation, clinicians must choose between modes of ventilation that directly control tidal volumes ("volume control"), modes that directly control the inspiratory airway pressure ("pressure control"), and modes that are hybrids ("adaptive pressure control"). Whether the choice of the mode used to target low tidal volumes and low inspiratory plateau pressures affects clinical outcomes for critically ill adults receiving mechanical ventilation is unknown. All three modes of mechanical ventilation are commonly used in clinical practice. A large, multicenter randomized trial comparing available modes of mechanical ventilation is needed to understand the effect of each mode on clinical outcomes. The investigators propose a 9-month cluster-randomized cluster-crossover pilot trial evaluating the feasibility of comparing three modes (volume control, pressure control, and adaptive pressure control) for mechanically ventilated ICU patients with regard to the outcome of days alive and free of invasive mechanical ventilation.

Vanderbilt University Medical CenterKevin P. Seitz, MD, MSc

25 Clinical Trials Nashville Near Me

Top Cities for Clinical Trials Nashville

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Nashville

262Active Trials

Vanderbilt University Medical CenterTop Active Site

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New York

211Active Trials

Memorial Sloan Kettering Cancer CenterTop Active Site