This trial is evaluating whether Ibuprofen will improve 1 primary outcome and 2 secondary outcomes in patients with Sleep Apnea, Obstructive. Measurement will happen over the course of 1.5 years.
This trial requires 120 total participants across 2 different treatment groups
This trial involves 2 different treatments. Ibuprofen is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are in Phase 3 and have had some early promising results.
This is a review of the current understanding of the causes of sleep apnea, obstructive. It is a difficult and sometimes fatal disease and a discussion of what the treatment is and whether or not it is a good medical management.
The most common treatment for [sleep apnea](https://www.withpower.com/clinical-trials/sleep-apnea), obstructive, in males is a nasal continuous positive airway pressure (CPAP) device (also called a nasal positive airway pressure monitor), which attaches to the nose on the inside forehead and connects to a patient's breathing system via tubing implanted from the nose to the patient's airway so that air is breathed automatically. Treatment is typically prescribed for sleep apnea for patients with chronic sleep apnea who do not benefit from or cannot tolerate continuous positive airway pressure (CPAP) therapy. The nasal CPAP may decrease daytime sleepiness and fatigue, as well as improve quality of life and the overall sleep architecture of a person with sleep apnea.
Sleep apnea, obstructive is characterized primarily by recurrent episodes of obstructive breathing during sleep. The episodes of mild to moderate hypopnea with a decrease in respiratory effort during sleep are the most predominant abnormalities. Oxyhemoglobin desaturation is the major contributing factor that leads to excessive daytime sleepiness and other health problems resulting from the sleep-disordered breathing syndrome. In addition, hypopnea with a reduction of baseline airway resistance, such as that found in sleep apnea, obstructive, is the underlying pathological mechanism or mechanism of the occurrence of central sleep apnea, which includes central apnea, central sleep apnea with hypopnea, and obstructive central sleep apnea.
If sleep apnea is a trigger in a patient's breathing issues, then CPAP has been shown to be effective in reducing severity of obstructive sleep apnea symptoms.
About 0.9 million people are diagnosed with sleep apnea, obstructive in the Unites States a year. There is a wide variability in the prevalence and severity of sleep apnea in the USA with estimates varying between 0.5 and 2.5 million. The variation in prevalence estimates reflects differences in inclusion criteria and cut thresholds used in the different studies.
Symptoms of obstructive sleep apnoea typically present themselves when people are tired and should include excessive daytime sleepiness and night-time awakening due to sleepiness, restless legs, excessive daytime sleepiness, difficulty concentrating, and heavy daytime fatigue. Moreover, a positive airway resistance index should be performed in each patient to diagnose sleep apnoea.
sleep apnea causes significant health complications. There is the need for further study on sleep apnea. There are a number of treatments available both OSA related and non OSA related treatments. As more data becomes available, we will eventually be able to establish more precise guidelines regarding the management of sleep apnea.
In these well-trained patients with mild to moderate OSA, ibuprofen was significantly more effective in reducing the AHI and the number of OSA episodes during daytime sleep than a placebo.
Subjects who are at higher risk for a poor clinical outcome should be evaluated to gain a full picture of prognosis before participation in a phase 3 trial.
Sleep-disordered breathing is the most common sleep disorder in children, so evaluating for sleep apnea is important. Obesity and airway resistance are the other leading causes of sleep apnea. A combination of the above factors may cause the syndrome.
There are many new medicines, devices, and techniques that clinicians can use to control sleep apnea. Although there has been research on the new treatments for sleep apnea, it has been slow to show the effectiveness of the therapies on quality of life and survival. Until the results from the studies on new treatments for sleep apnea become more convincing, there are no obvious therapeutic recommendations for patients with obstructive sleep apnea as of 2018. Sleep Apnea – Obstructive.
It remains to be seen how ibuprofen will be used in patients with obstructive sleep apnea. However, studies have reported positive effects in this population. ClinicalTrials.gov, National Institutes of Health [http://clinicaltrials.gov/ct2/show/NCT00257914?term=ibuprofen&selector=ibuprofen&search=yes&rank=10&site=&cnnLinkup] (NCT00257914) and the FDA's (NCT00382810) have shown positive results thus far from ibuprofen.