250 Participants Needed

Echocardiography for Anesthesia Effects on Heart Function

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GF
Overseen ByGregory Fischer, MD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Memorial Sloan Kettering Cancer Center
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial studies how general anesthesia affects heart function and blood flow in people who experience low blood pressure during surgery.

Will I have to stop taking my current medications?

If you are taking beta-blockers or anti-hypertensive medications, you will need to stop taking them to participate in this trial.

Is echocardiography safe for use in humans during anesthesia?

Echocardiography is a non-invasive and safe method used to assess heart function during anesthesia. It has been widely adopted in cardiac anesthesia and critical care without reported safety concerns.12345

How is echocardiography used to assess anesthesia effects on heart function different from other treatments?

Echocardiography is unique because it is a non-invasive imaging technique that allows doctors to see how the heart is functioning in real-time during anesthesia, unlike other treatments that may not provide immediate visual feedback on heart performance.34678

What data supports the effectiveness of the treatment Echocardiography for Anesthesia Effects on Heart Function?

Echocardiography, a heart imaging technique, is shown to be a noninvasive and safe method for assessing heart function during surgery, which can help manage anesthesia and monitor heart performance effectively.2491011

Who Is on the Research Team?

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Anahita Dabo-Trubelja, MD

Principal Investigator

Memorial Sloan Kettering Cancer Center

Are You a Good Fit for This Trial?

This trial is for adults over 18 who need general anesthesia for surgery, with at least a 20-minute prep time before incision and normal blood pressure. It's not for those in emergency surgery, on anti-hypertensive or beta-blocker medications, or with a history of heart disease.

Inclusion Criteria

I am 18 or older and need general anesthesia for surgery.
My surgery is expected to start 20 minutes after preparation.
I will need a breathing tube for my surgery.
See 1 more

Exclusion Criteria

I need a fast process for being put on a breathing machine.
I have a history of heart artery problems.
I need emergency surgery.
See 5 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo routine anesthetic and perioperative care with the addition of echocardiography and Clearsight BP measurement

During surgery
1 visit (in-person)

Follow-up

Participants are monitored for changes in heart function and blood flow post-anesthesia

up to 20 minutes after anesthesia induction

What Are the Treatments Tested in This Trial?

Interventions

  • Echocardiography
Trial Overview The study uses echocardiography to observe how general anesthesia affects heart function and blood flow during surgery, especially when patients have low blood pressure after receiving anesthesia.
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: EchocardiographyExperimental Treatment1 Intervention
Patients participating in this study will undergo routine anesthetic and perioperative care with the addition of an echocardiography and Clearsight BP measurement.

Find a Clinic Near You

Who Is Running the Clinical Trial?

Memorial Sloan Kettering Cancer Center

Lead Sponsor

Trials
1,998
Recruited
602,000+

Published Research Related to This Trial

Preoperative echocardiography in patients with cardiovascular risk undergoing major abdominal surgery did not lead to differences in 30-day mortality or postoperative cardiovascular complications, indicating it may not improve overall outcomes.
However, echocardiography was associated with a lower incidence of cardiac output monitoring during surgery, suggesting it may influence intraoperative anesthetic management practices.
Effect of performing preoperative echocardiography in patients with cardiovascular risk on intraoperative anesthetic management and postoperative outcomes: A retrospective study.Park, JH., Park, YH., Lee, B., et al.[2022]
Recent advances in perioperative echocardiography are enhancing the ability of cardiac anesthesiologists to assess and manage patients during surgery, particularly in areas like mitral valve imaging and critical care.
The role of echocardiography in perioperative care is becoming increasingly important, highlighting the need for cardiac anesthesiologists to be proficient in these techniques to improve patient outcomes.
Noteworthy Literature published in 2017 for Perioperative Echocardiography.Goeddel, LA., Kostibas, M., Metkus, T., et al.[2018]
In a study of 31 patients experiencing hemodynamic instability during noncardiac surgery, modified 'rescue' echocardiography successfully identified specific causes of instability in all cases, including left-heart dysfunction and hypovolemia.
The use of echocardiography led to timely interventions, with 13% of patients requiring and surviving an emergent secondary procedure, and 81% of patients ultimately being discharged from the hospital after recovery.
Use of rapid "rescue" perioperative echocardiography to improve outcomes after hemodynamic instability in noncardiac surgical patients.Shillcutt, SK., Markin, NW., Montzingo, CR., et al.[2019]

Citations

Effect of performing preoperative echocardiography in patients with cardiovascular risk on intraoperative anesthetic management and postoperative outcomes: A retrospective study. [2022]
Noteworthy Literature published in 2017 for Perioperative Echocardiography. [2018]
Use of rapid "rescue" perioperative echocardiography to improve outcomes after hemodynamic instability in noncardiac surgical patients. [2019]
[Noninvasive monitoring using echocardiography. II. Determination of cardiac output and comparison of volatile anesthetics]. [2013]
Focused cardiovascular ultrasound performed by anesthesiologists in the perioperative period: feasible and alters patient management. [2022]
[The role of echocardiography in preoperative diagnosis of cardiac risk in patients before non-cardiac surgical interventions]. [2016]
Echocardiographic assessment of ventricular performance following induction with two anesthetics. [2019]
A review of echocardiography in anaesthetic and peri-operative practice. Part 2: training and accreditation. [2015]
9.Czech Republicpubmed.ncbi.nlm.nih.gov
Effects of isoflurane concentration on basic echocardiographic parameters of the left ventricle in rats. [2020]
Effects of anesthesia on echocardiographic assessment of left ventricular structure and function in rats. [2022]
Decline in ventricular function as a result of general anesthesia in pediatric heart transplant recipients. [2018]
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