Primary Progressive Aphasia Clinical Trials
Here are the 6 most popular medical studies for primary progressive aphasia
Behavioural Intervention
Home-based multicomponent exercise intervention program for Aphasia
This trial is testing a new exercise program that can be done at home by adults with Primary Progressive Aphasia. The goal is to see if the program is practical and effective.
Behavioural Intervention
Transmagnetic Stimulation for Primary Progressive Aphasia
This trial studies a non-invasive therapy for Frontotemporal Degeneration (FTD), a type of dementia, using brain scans and magnetic stimulation. The goal is to improve symptoms and support current treatment.
Popular filter options for primary progressive aphasia trials
PPA Clinical Trials
View 28 PPA medical studies.
Behavioural Intervention
TMS for Primary Progressive Aphasia
This trial is testing whether non-invasive repetitive transcranial brain stimulation (rTMS), which induces electric currents in degenerating brain networks, can help people with Primary Progressive Aphasia (PPA), a progressive syndrome in the family of Alzheimer's disease and related disorders involving devastating language impairments caused by selective neurodegeneration of the brain's language network.
Device
HD-tDCS + mCILT for Primary Progressive Aphasia
This trial is testing whether high-definition transcranial direct current stimulation (HD-tDCS) paired with modified constraint-induced language therapy (mCILT) can improve language performance in people with primary progressive aphasia (PPA). The study will compare changes in language performance and brain imaging before and after receiving 10 semi-consecutive daily sessions of real or sham HD-tDCS + mCILT. The 3-month follow-up will be the primary endpoint.
Frontotemporal Dementia Clinical Trials
View 24 Frontotemporal Dementia medical studies.
Behavioural Intervention
Speech-Language Therapy for Frontotemporal Dementia
This trial will investigate the effects of high definition transcranial direct current stimulation (HD-tDCS) on language abilities in people with primary progressive aphasia (PPA), a neurodegenerative disease that affects language. HD-tDCS will be administered in combination with language therapy, and the effects will be compared to those of language therapy alone.
Behavioural Intervention
Speech-Language Therapy for Primary Progressive Aphasia
This trial seeks to study how tailored speech-language interventions help bilingual individuals with PPA. Researchers will evaluate effects of treatment, language use, and brain scans to determine best approach.
Hormone Therapy
Oxytocin Nasal Spray for Frontotemporal Dementia
This trial is testing the safety and effects of oxytocin given as a nasal spray to people with frontotemporal dementia or Pick's disease, compared to a placebo. Approximately 112 patients will be enrolled at 15 centers in the US and Canada, and will be given either oxytocin or the placebo nasal spray. The trial will happen in two phases, first testing different doses of oxytocin to see which is most effective, and then randomly assigning patients in the second phase to either the most effective dose of oxytocin or the placebo.
Primary Progressive Aphasia Clinical Trials With No Placebo
View 54 primary progressive aphasia medical studies that do not have a placebo group.
Behavioural Intervention
TMS for Primary Progressive Aphasia
This trial is testing whether non-invasive repetitive transcranial brain stimulation (rTMS), which induces electric currents in degenerating brain networks, can help people with Primary Progressive Aphasia (PPA), a progressive syndrome in the family of Alzheimer's disease and related disorders involving devastating language impairments caused by selective neurodegeneration of the brain's language network.
Aphasia Rehabilitation for Primary Progressive Aphasia
This trial is testing a new approach to treating word-finding problems in patients with Primary Progressive Aphasia or Alzheimer's Disease, by trying to strengthen the neural connections that remain functional.
View More Primary Progressive Aphasia Trials
See another 26 medical studies focused on primary progressive aphasia.
Frequently Asked Questions
Introduction to primary progressive aphasia
What are the top hospitals conducting primary progressive aphasia research?
When it comes to advancing our understanding of primary progressive aphasia, several top hospitals are leading the way in conducting clinical trials. In Baltimore, Johns Hopkins Hospital is at the forefront with four ongoing trials focused on this rare neurological condition characterized by a progressive loss of language abilities. With their first recorded trial in 2023, they are committed to exploring innovative approaches and potential treatments for primary progressive aphasia. Similarly, the University of Pennsylvania in Philadelphia has three active trials dedicated to studying this disorder that affects communication skills. They too began their journey into primary progressive aphasia research in 2023.
Meanwhile, the University of Texas in Austin has taken up the challenge with two ongoing trials since recording their first study back in 2017. Their efforts contribute immensely to unraveling the complexities surrounding primary progressive aphasia and offer hope for future interventions. Mayo Clinic located in Rochester also plays a significant role with two currently running trials as part of their extensive experience which dates back to 2010 when they began investigating this enigmatic condition.
Notably, among these distinguished institutions stands out Memory and Aging Center at the University of California, San Francisco where researchers are actively conducting one trial targeting primary progressive aphasia—a testament to their commitment towards unravelling mysteries within neurodegenerative diseases like these; although yet untouched territory concerning PPA's progressional treatment options—new doors open through each investigation conducted here.
These renowned hospitals across different regions demonstrate unwavering dedication toward making breakthroughs that could potentially benefit individuals living with primary progressive aphasia and improve their quality of life significantly. Through collaborative efforts such as these clinical trials conducted nationwide, we inch ever closer towards better comprehension and potentially life-changing therapeutic solutions for those affected by this challenging condition.
Which are the best cities for primary progressive aphasia clinical trials?
When it comes to primary progressive aphasia clinical trials, several cities are at the forefront of research. Baltimore, Maryland offers 5 active studies exploring treatments like Active tDCS + Language Therapy and High-definition active tDCS (HD-tDCS) + "Repeat After Me" (RAM) Treatment. Austin, Texas has 3 ongoing trials focusing on interventions such as RS-LRT and Video-Implemented Script Training for Aphasia (VISTA). Philadelphia, Pennsylvania also hosts 3 active trials investigating options like Active tDCS + Language Therapy and HD-tDCS+mCILT. San Francisco, California and Rochester, Minnesota each have 2 studies underway examining approaches including RS-LRT and F-18 AV 1451. These cities provide patients with primary progressive aphasia access to cutting-edge research that may lead to improved treatment outcomes.
Which are the top treatments for primary progressive aphasia being explored in clinical trials?
Clinical trials are actively exploring novel treatments for primary progressive aphasia. One promising approach involves the combination of active transcranial direct current stimulation (tdcs) with language therapy, currently being evaluated in a single ongoing trial since 2023. Another innovative treatment under investigation is Video-Implemented Script Training for Aphasia (VISTA), which utilizes video-based techniques to aid individuals with aphasia. This intervention is also being studied in one active trial and was first listed in 2017. These pioneering treatments offer hope for individuals living with primary progressive aphasia and may potentially improve their quality of life through enhanced communication abilities.
What are the most recent clinical trials for primary progressive aphasia?
In the realm of primary progressive aphasia, recent clinical trials have sparked hope for novel treatment approaches. One such trial involves remotely supervised tdcs and word-naming practice, which has entered Phase 2 as of November 1st, 2022. Another study explores the potential benefits of HD-tDCS+mCILT in individuals with primary progressive aphasia, also currently in Phase 2 since August 17th, 2020. Additionally, AV-1451 is being investigated in a Phase 4 trial that began on July 1st, 2018. These pioneering efforts offer promising prospects towards improving the lives of those affected by this challenging condition.
What primary progressive aphasia clinical trials were recently completed?
Recently completed clinical trials have made significant strides in the field of primary progressive aphasia. These trials focused on evaluating novel treatments and therapies to address this specific neurodegenerative disorder. While details may vary, three noteworthy studies were recently concluded. With promising results, these trials offer hope for individuals affected by primary progressive aphasia and their loved ones as researchers continue to explore innovative approaches to manage and potentially halt its progression.