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tDCS + CILT for Aphasia

N/A
Waitlist Available
Led By Sharyl A Samargia-Grivette, Ph.D.
Research Sponsored by University of Minnesota
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
history of stroke
diagnosed with non-fluent aphasia
Timeline
Screening 3 weeks
Treatment Varies
Follow Up follow up assessment after second treatment phase: visit 17: 2 week after second baseline
Awards & highlights

Study Summary

This trial will test the effect of combining two therapies, constraint-induced language therapy and cerebellar tDCS, to see if it improves language skills in adults with non-fluent aphasia after a stroke.

Who is the study for?
This trial is for adults over 18 with non-fluent aphasia, typically from a stroke. Participants must understand simple directions, be able to speak somewhat, have reliable transportation, and be fluent in English before their stroke. It's not for pregnant individuals or those with seizures, metal implants (except dental fillings), scalp psoriasis/eczema, head injuries like concussions, or other neurological/mental health conditions.Check my eligibility
What is being tested?
The study tests if brain stimulation (tDCS) combined with language therapy (CILT) helps speech and memory in people who struggle to speak after a stroke. There are two parts: real tDCS and fake (sham) treatment each given three times a week for two weeks with a month break between them. Speech therapists trained in CILT provide additional therapy during sessions.See study design
What are the potential side effects?
Possible side effects of tDCS may include discomfort at the electrode site on the scalp, itching or tingling during stimulation, headache or fatigue post-treatment. The risk of serious side effects is considered low but will be monitored throughout the study.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have had a stroke in the past.
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I have been diagnosed with a speech disorder affecting my fluency.
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I am over 18 years old.
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I have had a stroke in the past.
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I have been diagnosed with difficulty in forming words or sentences.
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I have reliable means to get to my appointments.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~follow up assessment after second treatment phase: visit 17: 2 week after second baseline
This trial's timeline: 3 weeks for screening, Varies for treatment, and follow up assessment after second treatment phase: visit 17: 2 week after second baseline for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Discourse Analysis: Picture Description
Discourse Analysis: Procedural
Discourse Analysis: Story Retell
+2 more
Secondary outcome measures
EEG: Coherence
EEG: Power spectral analysis
Stroke Aphasia Quality of Life (SA-QOL)
+1 more

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: Real tDCSActive Control1 Intervention
the participant receives real tDCS to the right cerebellum during behavioral intervention (CILT)
Group II: Sham tDCSPlacebo Group1 Intervention
the participant receives sham tDCS to the right cerebellum during behavioral intervention (CILT)

Find a Location

Who is running the clinical trial?

University of MinnesotaLead Sponsor
1,367 Previous Clinical Trials
1,587,504 Total Patients Enrolled
1 Trials studying Aphasia
3 Patients Enrolled for Aphasia
Sharyl A Samargia-Grivette, Ph.D.Principal InvestigatorUniversity of Minnesota

Media Library

Real tDCS Clinical Trial Eligibility Overview. Trial Name: NCT05561400 — N/A
Aphasia Research Study Groups: Real tDCS, Sham tDCS
Aphasia Clinical Trial 2023: Real tDCS Highlights & Side Effects. Trial Name: NCT05561400 — N/A
Real tDCS 2023 Treatment Timeline for Medical Study. Trial Name: NCT05561400 — N/A
Aphasia Patient Testimony for trial: Trial Name: NCT05561400 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any slots remaining for patients to join this scientific trial?

"The information provided on clinicaltrials.gov shows that this specific study is no longer taking in enrolments, as its last update was registered 11/8/2022 - it originally began recruiting volunteers on 1/25/2023. However, 1376 other studies are still open for participant recruitment."

Answered by AI

What goals are this clinical experiment striving to attain?

"The primary focus of this study is to conduct a Discourse Analysis on Picture Description. Secondary metrics that are being monitored include Working Memory (measured using the Wisconsin Card Sorting Test), EEG: Peak Alpha Frequency, and Stroke Aphasia Quality of Life (SA-QOL). The scores for these outcomes will be tracked over two weeks after the second baseline visit; higher values indicate better performance."

Answered by AI

Who else is applying?

What state do they live in?
Massachusetts
Ontario
Tennessee
What site did they apply to?
University of Minnesota
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
1

Why did patients apply to this trial?

I've been looking for something for Brian's aphasia for a long time - something other than speech therapy.
PatientReceived 2+ prior treatments

How responsive is this trial?

Most responsive sites:
  1. University of Minnesota: < 48 hours
Average response time
  • < 2 Days
Typically responds via
Email
~3 spots leftby Mar 2025