ccPAS group for Aphasia

Shirley Ryan AbilityLab, Chicago, IL
Aphasia+1 More ConditionsCortico-cortical paired associative stimulation - Device
Eligibility
18+
All Sexes

Study Summary

This trial will look at how brain stimulation and speech therapy can help stroke patients with language problems.

Eligible Conditions
  • Aphasia
  • Stroke

Treatment Effectiveness

Study Objectives

1 Primary · 4 Secondary · Reporting Duration: Visit 3 (baseline, pre-intervention), Visit 7 (midpoint, of intervention), Visit 12 (immediately post-intervention), and Visit 13 (maintenance, 1-month post-intervention).

Day 10
Changes in functional connectivity with resting-state functional magnetic resonance imaging (rs-fMRI)
Visit 1 (baseline, pre-intervention), Visit 12 (immediately post-intervention), and Visit 13 (maintenance, 1-month post-intervention).
Changes in the Western Aphasia Battery-Revised (WAB-R) Reading subtest
Visit 3 (baseline, pre-intervention), Visit 12 (immediately post-intervention), and Visit 13 (maintenance, 1-month post-intervention).
Changes in production of connected speech using standardized expositional discourse stimuli (Broken Window and Cat in Tree picture scenes)
Changes on The Short-Form Philadelphia Naming Test (PNT)
Visit 3 (baseline, pre-intervention), Visit 7 (midpoint, of intervention), Visit 12 (immediately post-intervention), and Visit 13 (maintenance, 1-month post-intervention).
Changes in oral reading probes

Trial Safety

Trial Design

2 Treatment Groups

ccPAS group
1 of 2
Sham ccPAS group
1 of 2

Experimental Treatment

Non-Treatment Group

10 Total Participants · 2 Treatment Groups

Primary Treatment: ccPAS group · Has Placebo Group · N/A

ccPAS group
Device
Experimental Group · 1 Intervention: Cortico-cortical paired associative stimulation · Intervention Types: Device
Sham ccPAS group
Device
ShamComparator Group · 1 Intervention: Sham cortico-cortical paired associative stimulation · Intervention Types: Device

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: visit 3 (baseline, pre-intervention), visit 7 (midpoint, of intervention), visit 12 (immediately post-intervention), and visit 13 (maintenance, 1-month post-intervention).

Who is running the clinical trial?

Shirley Ryan AbilityLabLead Sponsor
177 Previous Clinical Trials
13,804 Total Patients Enrolled
9 Trials studying Aphasia
411 Patients Enrolled for Aphasia
Julio Hernandez Pavon, PhDPrincipal InvestigatorShirley Ryan AbilityLab

Eligibility Criteria

Age 18+ · All Participants · 3 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have difficulty speaking due to a stroke in the left side of your brain.
You are right-handed.
You are able to participate in magnetic resonance imaging (MRI) or transcranial magnetic stimulation (TMS) testing.

Frequently Asked Questions

Is enrollment still open for the trial participants?

"According to clinicaltrials.gov, this medical study has begun recruiting patients and is open for enrollment. The initial posting date was September 1st 2023 while the most recent edit occured on December 20th 2022." - Anonymous Online Contributor

Unverified Answer

What is the maximum number of participants being accepted into this clinical trial?

"Indeed, the information on clinicaltrials.gov shows that this research is still open to recruiting participants. The trial was initially published on September 1st 2023 and has been revised as of December 20th 2022. A total of 10 individuals are expected to be recruited from only one site." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.