104 Participants Needed

Sentence Training for Aphasia

JL
JL
Overseen ByJiyeon Lee
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Purdue University
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to improve sentence production and comprehension in people with aphasia using a technique that subtly influences the brain to enhance language skills without the person being fully aware of it. The goal is to create lasting improvements in language abilities by frequently exposing the brain to certain language patterns.

Do I need to stop my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Is Sentence Training for Aphasia safe for humans?

The research articles do not provide specific safety data for Sentence Training for Aphasia, but they focus on its effects on sentence production and comprehension in people with aphasia.12345

How is Sentence Production Training different from other treatments for aphasia?

Sentence Production Training is unique because it uses structural priming, a technique that helps people with aphasia improve their ability to form sentences by repeatedly exposing them to certain sentence structures. This method focuses on implicit learning, which means patients can improve their sentence production without needing to consciously think about the rules of grammar.12356

What data supports the effectiveness of the treatment Sentence Production Training, Sentence Production Training, Implicit Structural Priming Therapy for aphasia?

Research shows that structural priming, a key part of this treatment, helps people with aphasia improve their ability to form sentences. Studies found that this method can lead to lasting improvements in sentence production, even in those with severe language impairments.12356

Who Is on the Research Team?

JL

Jiyeon Lee, PhD

Principal Investigator

Purdue University

Are You a Good Fit for This Trial?

This trial is for English-speaking adults who had a stroke in the left hemisphere of their brain at least 6 months ago, causing aphasia. They should have completed high school and have normal or corrected vision and hearing. Participants must struggle with forming sentences but can use some words independently. Those with uncontrolled mental health issues, substance abuse, severe speech apraxia, or other neurological conditions affecting communication cannot join.

Inclusion Criteria

High-school educated
It's hard for you to talk in full sentences, and you can only say some words by themselves.
It has been over 6 months since I had a stroke affecting my left side.
See 4 more

Exclusion Criteria

You currently have a problem with alcohol or drugs.
I have severe difficulty speaking clearly.
You have other conditions that affect how you communicate, like dementia.
See 1 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo structural priming training sessions to improve sentence production and comprehension

Up to 15 sessions
3 sessions for experiments 1-3, up to 15 sessions for experiment 4

Follow-up

Participants are monitored for improvements in sentence production and comprehension post-treatment

Up to 2 months

What Are the Treatments Tested in This Trial?

Interventions

  • Sentence Production Training
Trial Overview The study is testing a new method to improve sentence formation and understanding in people with aphasia using 'implicit priming'. Researchers will first identify the most effective priming conditions for learning enhancement before developing and evaluating a novel treatment based on these initial findings.
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: Structural priming trainingExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Purdue University

Lead Sponsor

Trials
239
Recruited
72,200+

Temple University

Collaborator

Trials
321
Recruited
89,100+

University of California, San Diego

Collaborator

Trials
1,215
Recruited
1,593,000+

Published Research Related to This Trial

In a study involving 11 persons with aphasia (PWA) and 20 healthy older adults (HOA), it was found that lexical priming significantly influenced off-line sentence production in PWA, particularly for those with better-preserved syntactic processing.
While HOA demonstrated immediate word-driven production in both off-line and real-time measures, PWA showed a delay in preferential eye fixations to the primed character, indicating atypical sentence planning despite successful off-line production.
Effect of lexical accessibility on syntactic production in aphasia: An eyetracking study.Lee, J.[2022]
Eighteen individuals with aphasia (PWA) showed preserved structural priming effects during sentence comprehension, indicating that they can benefit from this technique to improve their understanding of syntactically ambiguous sentences.
The study found that PWA and healthy older adults both exhibited structural priming effects even after a delay, suggesting that this form of priming can facilitate longer-lasting improvements in sentence interpretation, although it did not rely on specific verb information.
Priming sentence comprehension in aphasia: Effects of lexically independent and specific structural priming.Lee, J., Hosokawa, E., Meehan, S., et al.[2023]
In a study involving five participants with nonfluent aphasia, it was found that they produced sentences more accurately when starting with high-frequency nouns, indicating that lexical retrieval speed significantly impacts their sentence production.
The nonfluent participants struggled more with sentences containing semantically related nouns, suggesting they rely heavily on activated concepts to form sentences, which supports the 'content drives structure' (COST) hypothesis.
What's in a sentence? The crucial role of lexical content in sentence production in nonfluent aphasia.Speer, P., Wilshire, CE.[2018]

Citations

Effect of lexical accessibility on syntactic production in aphasia: An eyetracking study. [2022]
Priming sentence comprehension in aphasia: Effects of lexically independent and specific structural priming. [2023]
What's in a sentence? The crucial role of lexical content in sentence production in nonfluent aphasia. [2018]
Effects of Verb Overlap on Structural Priming in Dialogue: Implications for Syntactic Learning in Aphasia. [2023]
Grammatical Encoding and Learning in Agrammatic Aphasia: Evidence from Structural Priming. [2020]
TelePriming sentence production in aphasia. [2023]
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