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Telemedicine Interventions for Aphasia (PICTURE IT Trial)

N/A
Recruiting
Led By Argye E Hillis, MD
Research Sponsored by Johns Hopkins University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 1 week after treatment
Awards & highlights
No Placebo-Only Group

Summary

This trial is testing two types of speech therapy for stroke patients who have trouble speaking. One therapy engages the right side of the brain, and the other helps with naming objects. The goal is to see which therapy improves speech better.

Who is the study for?
This trial is for adults over 18 who've had a stroke between 1 to 4 months ago, leading to aphasia with difficulty in naming objects. Participants must be able to give consent and understand therapy tasks. It's not for those with severe vision/hearing loss, non-English speakers, or individuals with other brain-affecting diseases or severe psychiatric conditions.
What is being tested?
The PICTURE IT study tests two language therapies using telemedicine for post-stroke aphasia: one stimulates the right side of the brain (PICTURE IT) and another computer-based treatment improves naming (CoDeLT). The effectiveness of each will be compared in a randomized order with blinded assessors.
What are the potential side effects?
Since this trial involves behavioral language treatments rather than drugs, traditional side effects are not expected. However, participants may experience fatigue or frustration during therapy sessions due to the challenges associated with learning and practicing new skills.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 1 week after treatment
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 1 week after treatment for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in discourse content as assessed by z-score for the number of meaning-carrying units used in describing a picture
Secondary study objectives
Change in accuracy of naming actions as assessed by the Hopkins Action Naming Assessment form
Change in accuracy of naming objects as assessed by the Boston Naming Test
Change in discourse informational efficiency as assessed by z-score for the number of syllables of meaning-carrying units used in describing a picture
+1 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: PICTURE IT Intervention-CoDeLT InterventionExperimental Treatment2 Interventions
Participants will receive PICTURE IT Intervention for 15 sessions followed by Computer Delivered Lexical Treatment (CoDeLT)Intervention for 15 sessions
Group II: CoDeLT Intervention-PICTURE IT InterventionActive Control2 Interventions
Participants will receive Computer Delivered Lexical Treatment (CoDeLT) Intervention for 15 sessions followed by PICTURE IT Intervention for 15 sessions

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.
Mechanism Of Action
Side Effect Profile
Prior Approvals
Other Research
Common treatments for aphasia, such as non-invasive brain stimulation (e.g., transcranial direct current stimulation, tDCS) and behavioral language therapies, aim to enhance neural reorganization and improve language functions. Non-invasive brain stimulation techniques like tDCS modulate cortical excitability, potentially facilitating neural plasticity and recovery in language networks. Behavioral therapies, including those targeting right hemisphere functions, engage patients in structured language tasks to stimulate neural pathways involved in language processing. These treatments are crucial for aphasia patients as they can lead to improvements in language abilities, thereby enhancing communication skills and overall quality of life.
Anodal transcranial direct current stimulation in early rehabilitation of patients with post-stroke non-fluent aphasia: a randomized, double-blind, sham-controlled pilot study.Noninvasive brain stimulation for treatment of right- and left-handed poststroke aphasics.Non-invasive brain stimulation (NIBS) and motor recovery after stroke.

Find a Location

Who is running the clinical trial?

Johns Hopkins UniversityLead Sponsor
2,333 Previous Clinical Trials
14,875,525 Total Patients Enrolled
Argye E Hillis, MDPrincipal InvestigatorJohns Hopkins University

Media Library

CoDeLT Clinical Trial Eligibility Overview. Trial Name: NCT05845047 — N/A
Hypercoagulability Research Study Groups: CoDeLT Intervention-PICTURE IT Intervention, PICTURE IT Intervention-CoDeLT Intervention
Hypercoagulability Clinical Trial 2023: CoDeLT Highlights & Side Effects. Trial Name: NCT05845047 — N/A
CoDeLT 2023 Treatment Timeline for Medical Study. Trial Name: NCT05845047 — N/A
~47 spots leftby Aug 2031