This trial is testing whether the diabetes drug metformin can improve outcomes in people with PH-HFpEF. The study will look at how well metformin works compared to placebo and what the effects are on heart function and capacity.
- Pulmonary Hypertension
- Heart Failure
1 Primary · 0 Secondary · Reporting Duration: 12 weeks (i.e. the 12th week of placebo vs 12th week of metformin)
Side Effects for
Awards & Highlights
2 Treatment Groups
1 of 2
Placebo Oral Capsule
1 of 2
10 Total Participants · 2 Treatment Groups
Primary Treatment: Metformin · Has Placebo Group · Phase 2
Who is running the clinical trial?
Age 18+ · All Participants · 0 Total Inclusion CriteriaMark “Yes” if the following statements are true for you:
Frequently Asked Questions
Has the FDA cleared Metformin for general use?
"Metformin is a medication that, according to our assessment, ranks as a 2 in terms of safety. This is due to it being in Phase 2 trials meaning while there is evidence suggesting it is safe, there is no data yet affirming its efficacy." - Anonymous Online Contributor
How many people fit the requirements to enroll in this experiment?
"That is correct. The clinical trial in question, which was first posted on February 26th 2019 and updated most recently on December 17th 2021, is currently seeking enrolment from 10 patients at 2 locations." - Anonymous Online Contributor
Are there any other ongoing investigations that include Metformin?
"Currently, 179 clinical trials involving Metformin are ongoing with 44 of those in the final stage. Many trials are based in Pittsburgh, but there are 1951 locations conducting research on this medication." - Anonymous Online Contributor
Are we still accepting participants for this experiment?
"That is correct. The clinicaltrials.gov website provides information which indicates that this study is still recruiting individuals. This trial was initially posted on February 26th, 2019 and updated December 17th, 2021. There are currently 10 patients enrolled at 2 locations." - Anonymous Online Contributor
What are the primary conditions that Metformin is indicated to treat?
"Metformin is a medication with many potential applications. It is commonly used to treat exercise, but it can also help manage type 1 diabetes mellitus, diabetic ketoacidosis, and polycystic ovary syndrome." - Anonymous Online Contributor