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Molecular Tumor Board

Molecular Tumor Board Recommendations for Cancer (CATRINA Trial)

N/A

Recruiting

Research Sponsored by Dartmouth-Hitchcock Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Subject must have ECOG Performance Status of 0 to 2.

Tumor must contain at least one of the following genetic alterations: (A) an alteration known to be potentially associated with sensitization to a clinically available treatment. (the list of genetic alterations evolves as new information emerges and new drugs are developed); (B) an alteration suspected to be germline.

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1 month after recommendation

Awards & highlights

CATRINA Trial Summary

This trial will measure the impact of Molecular Tumor Board recommendations on treatment decisions in a cancer center.

Who is the study for?

This trial is for adults over 18 with cancer, who are fairly active (ECOG Performance Status of 0 to 2), have tumors that can be measured or evaluated, and have given verbal consent. Their tumor must have been genetically profiled with at least 100 genes and contain certain genetic alterations that could respond to treatment.Check my eligibility

What is being tested?

The study tests how recommendations from the Dartmouth Cancer Center's Molecular Tumor Board affect doctors' treatment decisions. After genetic profiling of tumors, these personalized recommendations are made and their impact is assessed through physician surveys.See study design

What are the potential side effects?

Since this trial focuses on the impact of treatment recommendations rather than specific treatments themselves, side effects will vary based on individualized therapies chosen as a result of the Molecular Tumor Board's advice.

CATRINA Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am able to get out of my bed or chair and move around.

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My tumor has a genetic change that may respond to treatment or is inherited.

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My tumor was tested for over 100 genes.

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I am 18 years old or older.

CATRINA Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1 month after recommendation

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1 month after recommendation

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 month after recommendation for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Proportion of subjects for whom evaluation by Molecular Tumor Board impacts treatment decisions as reported by the treating physician.

Secondary outcome measures

Number of participants with progression-free survival after Molecular Tumor Board recommendations were made.

Proportion of subjects for whom Molecular Tumor Board recommends treatment with a tumor-targeted therapy or immunotherapy.

Proportion of subjects for whom Molecular Tumor Board-recommended germline genetic testing results in confirmation of a germline genetic lesion/mutation.

+2 more

CATRINA Trial Design

1Treatment groups

Experimental Treatment

Group I: Subjects evaluated by Molecular Tumor BoardExperimental Treatment1 Intervention

Subjects whose cases are evaluated by Molecular Tumor Board

0 / 4Eligibility criteria met

Find a Location

Who is running the clinical trial?

Dartmouth-Hitchcock Medical CenterLead Sponsor

524 Previous Clinical Trials

2,543,165 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many individuals are taking part in this clinical trial thus far?

"Affirmative. The information on clinicaltrials.gov indicates that this trial is actively seeking participants, with 174 individuals being recruited from 1 centre since its posting date of November 1st 2023 and last update on the 27th of that same month."

Answered by AI

Are there any vacancies to participate in this clinical experiment?

"According to the most recent information available on clinicaltrials.gov, this research is actively recruiting individuals for participation; it was first posted on November 1st and revised on November 27th of 2023."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

CAncer TReatment INformed by the Molecular Tumor Board At Dartmouth

Laura.J.Tafe 2024. "CAncer TReatment INformed by the Molecular Tumor Board At Dartmouth". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05405413.