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Neuropeptide Y for High Blood Pressure (OB-HTN Trial)

Phase < 1
Recruiting
Research Sponsored by University of Texas Southwestern Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Control - BMI<30, age 18-55
Obese-hypertensive- BMI>30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring
Timeline
Screening 3 weeks
Treatment Varies
Follow Up acutely on the day of study
Awards & highlights

OB-HTN Trial Summary

This trial will help researchers understand how the nervous system communicates with blood vessels to increase blood pressure during stress, and how hypertension and obesity may influence this process.

Who is the study for?
This trial is for adults aged 18-55 who are either healthy, overweight (BMI>30), have high blood pressure, or both. Participants must not have other significant cardiovascular diseases, kidney disease, a history of smoking, or diabetes.Check my eligibility
What is being tested?
The study aims to understand how stress affects blood pressure in people with obesity and/or hypertension by measuring nervous system activity and blood flow during stress tests and drug-induced changes in vessel size.See study design
What are the potential side effects?
Potential side effects may include reactions to the infusion such as discomfort at the injection site or allergic reactions. Stress tests might cause temporary increases in heart rate or blood pressure.

OB-HTN Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 18 and 55 years old with a BMI under 30.
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I am between 18-55, have a BMI over 30, and diagnosed with high blood pressure.
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I am 18-55 years old, have a BMI under 30, and my high blood pressure was confirmed by a 24-hour monitor.
Select...
I am between 18 and 55 years old with a BMI over 30.
Select...
I am between 18 and 55 years old with a BMI under 30.

OB-HTN Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~acutely on the day of study
This trial's timeline: 3 weeks for screening, Varies for treatment, and acutely on the day of study for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Blood flow measured by doppler ultrasound
Muscle sympathetic nervous system activity

Side effects data

From 2017 Phase 4 trial • 18 Patients • NCT02639637
8%
paresthesias
8%
Light-headedness
100%
80%
60%
40%
20%
0%
Study treatment Arm
Sitagliptin (Diabetics and Controls)
Placebo and Valsartan (Controls Only)
Placebo (Diabetics and Controls)
Sitagliptin and Valsartan (Controls Only)

OB-HTN Trial Design

4Treatment groups
Experimental Treatment
Group I: Obese-hypertensiveExperimental Treatment1 Intervention
Obese adults who are being treated for hypertension
Group II: ObeseExperimental Treatment1 Intervention
Obese adults who are not hypertensive
Group III: HypertensiveExperimental Treatment1 Intervention
Hypertensive adults who are not obese
Group IV: Healthy ControlExperimental Treatment1 Intervention
Healthy age matched controls with no history of cardiovascular disease and normal bodyweight
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Neuropeptide Y
2012
Completed Phase 4
~50

Find a Location

Who is running the clinical trial?

University of Texas Southwestern Medical CenterLead Sponsor
1,043 Previous Clinical Trials
1,053,450 Total Patients Enrolled

Media Library

Neuropeptide Y Clinical Trial Eligibility Overview. Trial Name: NCT04838678 — Phase < 1
High Blood Pressure Research Study Groups: Hypertensive, Obese, Obese-hypertensive, Healthy Control
High Blood Pressure Clinical Trial 2023: Neuropeptide Y Highlights & Side Effects. Trial Name: NCT04838678 — Phase < 1
Neuropeptide Y 2023 Treatment Timeline for Medical Study. Trial Name: NCT04838678 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there vacancies available in this medical trial at present?

"As confirmed on clinicaltrials.gov, this medical experiment is actively looking for potential participants. The research was initially published on July 18th 2021 and most recently updated on August 8th 2022."

Answered by AI

Am I a viable candidate to participate in this research?

"This clinical trial requires 100 individuals aged 18-55 that fit into four different categories: Control (BMI<30), Hypertensive (BMI<30, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring) , Obese (BMI>30), and Obese-Hypertensive (BMI>30 with a diagnosis of hypertension by 24 hour ambulatory blood pressure monitoring)."

Answered by AI

What other research has employed Neuropeptide Y as its focus?

"At present, there is one ongoing clinical trial pertaining to Neuropeptide Y. This research does not have any Phase 3 trials running and the majority of testing is taking place in Dallas, Texas with a single other location involved as well."

Answered by AI

How many participants are being included in this research project?

"Affirmative. Clinicaltrials.gov has verified that this clinical trial, which was first published on July 18th 2021, is still actively recruiting patients at the moment. It is estimated that 100 people need to be enrolled from 1 medical centre in order for the study to move forward."

Answered by AI

Is the geriatric population being considered for involvement in this trial?

"The parameters for this trial necessitate that potential participants are aged between 18 and 55. If candidates do not meet these criteria, there exist 252 studies available to those under 18 years old or 1236 for elderly individuals over 65."

Answered by AI

Who else is applying?

What state do they live in?
Texas
How old are they?
18 - 65
What site did they apply to?
University of Texas Southwestern Medical Center
What portion of applicants met pre-screening criteria?
Met criteria
Did not meet criteria
How many prior treatments have patients received?
0

How responsive is this trial?

Typically responds via
Email
Most responsive sites:
  1. University of Texas Southwestern Medical Center: < 48 hours
Average response time
  • < 2 Days
~35 spots leftby Sep 2025