Primary Biliary Cirrhosis Clinical Trials

Primary Biliary Cirrhosis studies recruiting patients for novel treatments. Filter by phase, distance, and inclusion criteria to find your perfect primary biliary cirrhosis clinical trial.

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does primary biliary cirrhosis run in families?

Add answer

The findings suggest that PBC has an autosomal dominant mode of inheritance. Familial aggregation was seen in all four HLA Class I-defined subgroups, but did not occur in HLA Class II-defined subgroups. Results from a recent clinical trial supports the hypothesis that PBC runs in families.

Unverified Answer

What causes primary biliary cirrhosis?

Add answer

The etiology of PBC remains elusive; however, this article outlines the current research on the possible involvement of various infectious agents, autoimmune disorders, and environmental factors in triggering PBC. This article emphasizes the need for further investigation into this intriguing and challenging disease entity.

Unverified Answer

Can primary biliary cirrhosis be cured?

Add answer

Liver [transplant](https://www.withpower.com/clinical-trials/transplant)ation will cure PBC in about 40% of cases, while other treatments will not improve outcomes and may increase complications. There are no randomized controlled trials comparing these treatments.

Unverified Answer

What is the primary cause of primary biliary cirrhosis?

Add answer

Primary sclerosing cholangitis is the primary abnormality causing PBC. The interaction between immune system and liver tissue results in inflammation and fibrosis of the liver. The autoimmune process seems to be self-limiting, because the antibodies are present at low levels and do not seem to have any effect. If PBC continues to progress, then secondary causes such as infection, bile duct cancer, and gallstones become important. There are several types of PBC, and each has its own pattern of progression.

Unverified Answer

How many people get primary biliary cirrhosis a year in the United States?

Add answer

The prevalence of PBC is 0.4% in the US population per year, with a higher prevalence in women than men. The gold standard for diagnosis of PBC is liver biopsy.

Unverified Answer

What are common treatments for primary biliary cirrhosis?

Add answer

This is the first study which summarizes the most commonly used medical treatments of PBC in Denmark. Lipid-lowering drugs were often prescribed but have not been shown to prevent progression to ESCC. Statins were rarely used. Rheumatology referrals were frequent. Although rheumatologic interventions are not routinely performed in Denmark, our data show that they are frequently utilized. A prospective multicenter observational study is urgently needed to better define the necessity for these interventions.

Unverified Answer

What is the average age someone gets primary biliary cirrhosis?

Add answer

This population-based study shows that average age of onset of PBC is equal to 49.9 ± 8.6 yr in women and 44.1 ± 6.2 yr in men, suggesting similar incidence rates for both sexes, although there seems to be an earlier age of onset of PBC in women. The findings do not support previous reports from single referral centers, where early onset of PBC was found in young patients.

Unverified Answer

What are the signs of primary biliary cirrhosis?

Add answer

Results from a recent paper, we found SBA (sclerosing cholangitis) to be one of the most common extrahepatic manifestations of PBC. However, it is not a sign of disease activity.

Unverified Answer

Is the prevalence of autoimmune hepatitis less than 10% in patients with primary biliary cirrhosis?

Add answer

Autoimmune hepatitis is rare in PBC, so it should be considered in patients with abnormal liver function tests. In addition, the presence of antinuclear antibodies may support the diagnosis of autoimmune hepatitis in PBC.

Unverified Answer

Primary biliary cirrhosis?

Add answer

Patients with PBC had significantly lower scores on health-related quality-of-life measures than controls. The functional status was also impaired. Results from a recent paper suggest that health-related quality-of-life measures should be included in the routine assessment in this patient group.

Unverified Answer

Are increased serum levels of CD4+CD25+ regulatory T cells and IL-10 correlated with hepatic encephalopathy in primary biliary cirrhosis?

Add answer

Increased serum levels of Tregs and IL-10 were found to correlate with HE in PBC patients. This information might be useful in predicting HE and reversing its severity.

Unverified Answer

Are socio-demographic factors associated with liver cirrhosis in Korean patients with primary biliary cirrhosis?

Add answer

The prevalence of liver cirrhosis was significantly higher in women. Alcohol consumption was more common in men than women. Age was an independent risk factor for liver cirrhosis in all groups.

Unverified Answer