Cerebral Palsy Clinical Trials 2022

Browse 88 Cerebral Palsy Medical Studies Across 74 Cities

3 Phase 3 Trial · 140 Cerebral Palsy Clinics

Reviewed by Michael Gill, B. Sc.
Photo of Atlanta 1
Phase-Based Progress Estimates
1
Effectiveness
1
Safety

VRfor Cerebral Palsy

Atlanta, GA
< 18
All Sexes
Virtual reality (VR) has shown to be effective to improve arm function in children with cerebral palsy (CP). Recently, functional strength training (FST) starts to show to improve arm function in patients with stroke but has not been extensively explored in children with CP. This pilot study is to examine the effect of FST and VR on improving arm function in children with CP using a sequential multiple assignment randomized trial (SMART) to develop valid, high-quality adaptive intervention using VR and FST to improve arm function in children with CP. There is a growing interest and need for research on how to adapt and re-adapt intervention in children with CP in order to maximize clinical benefits. The treatment adapted here is by augmenting or switching to the other intervention. Forty children with spastic type of CP will be recruited from the greater Atlanta area. Children will be randomly assigned to receive either VR or FST for 6 weeks (60 minutes per day, 3 days per week). After receiving 6 weeks of intervention, the children will be evaluated to determine whether they are responders or non-responders. For those who are responders, they will continue receiving the same dosage and type of intervention. That is, children who are assigned to VR will continue receiving VR for the next 6 weeks; children who are assigned to FST will continue receiving FST for the next 6 weeks. For those who are non-responders, children will be randomly assigned to augmenting the other intervention or switching to the other intervention. That is, for children who are assigned to augmenting the other intervention (i.e. the combination group), they will receive the combination of FST and VR for the next 6 weeks. For children who are assigned to switch to the other intervention, children who are assigned to VR in the first 6 weeks will receive FST for the next 6 weeks; whereas children who are assigned to FST in the first 6 weeks will receive VR for the next 6 weeks. Similar instruction, visit, and email reminder will be conducted as what they receive in the first 6 weeks. At the end of the study, children and primary caregivers will be interviewed to understand their perception about the intervention they have received. The research team is expected children with CP will improve their arm function regardless which intervention they are assigned; however, children received VR will have a better improvement in arm function as compared with those who received FST at the end of the intervention.
Recruiting
Has No Placebo
Photo of Calgary 1
Phase-Based Progress Estimates
1
Effectiveness
1
Safety

Robotic Training Periodfor Brain Injuries

Calgary, Canada
Any Age
All Sexes
A common problem among children with nervous system disorders is difficulty walking on their own. This has impacts beyond mobility including short and long-term health conditions associated with physical inactivity and different developmental experiences as a result of the mobility impairments. A robotic trainer can both provide rehabilitation and be an assistive device to help compensate for difficulties. Figuring out how to prescribe it is critical to improve daily life for children with significant disabilities. Preliminary use of robotic trainers have shown many benefits, such as better head control and improved independence in transfers, which greatly increases ability to live independently. Additionally, vital functions that are frequently impaired in those with less physical activity, such as sleep and bowel habits, seem to improve. Finally, these children enjoy using them. This project aims to determine who is most likely to benefit from training with a robotic trainer and investigate key details about the dose of training that is needed. Families that are already using or hope to use robotic training need this data to help improve their access to the intervention. Clinicians need this systematic approach to building evidence to ensure a future multi-centre randomized control trial is well designed. This study is needed to help improve the lives of those who live with significant disabilities. The objective is to evaluate the feasibility and impacts of delivering robotic gait training at home. Integral in this study is capturing the user perspectives. This will both provide preliminary evidence-based advice to potential users, their families, and clinicians as well as provide key metrics to design a definitive multi-centre randomized control trial. The investigators will provide robotic gait trainers, specifically Trexo robotic gait trainers, to participants and their families to use in their home communities for 12 weeks to evaluate the feasibility and impacts of intensive robotic gait training in people who cannot walk independently. Assessments will be completed throughout the duration of study, including before, during, and after the training intervention, with the goal of evaluating a wide range of feasibility considerations and impacts from robotic training.
Recruiting
Has No Placebo
25 Cerebral Palsy Clinical Trials Near Me
Seattle, WA
Charlottesville, VA
Québec, Canada
Saint Paul, MN
More Trial Locations
An interactive map to display trial locations for University of Washington, University of Virginia Motion Analysis and Motor Performance Lab, Université Laval, Gillette Children's Specialty Healthcare, and 31 more locations.
Most Popular References for Cerebral Palsy Clinical Trials
Frequency
Citation
Top Hospitals for Cerebral Palsy Clinical Trials
Location
Active Cerebral Palsy Clinical Trials
All Time Trials for Cerebral Palsy
First Recorded Cerebral Palsy Trial
Trials
Gillette Children's Specialty Healthcare, Saint Paul, Minnesota
2
10
2012
Boys Town National Research Hospital, Boys Town, Nebraska
2
2
2020
Teachers College, Columbia University, New York, New York
2
4
2007
Top Treatments for Cerebral Palsy Clinical Trials
Treatment Name
Active Cerebral Palsy Clinical Trials
All Time Trials for Cerebral Palsy
First Recorded Cerebral Palsy Trial
Trials
SurePace Powered Walker User
1
1
2020
Intensive bimanual therapy
1
2
2017
Top Cities for Cerebral Palsy Clinical Trials
City
Active Cerebral Palsy Clinical Trials
Top Active Site for Cerebral Palsy Clinical Trials
Trial List
Phase 3 Cerebral Palsy Clinical Trials
Clinical Trial
Began Recruiting Date
Phase
Pediatric Cerebral Palsy Clinical Trials
Senior Friendly Cerebral Palsy Clinical Trials
Recently Completed Studies with FDA Approved Treatments for Cerebral Palsy
Treatment
Year
Mechanism of Action
Sponsor
Active Cerebral Palsy Clinical Trials
Deutetrabenazine
2019
Deutetrabenazine
Teva Branded Pharmaceutical Products R&D, Inc.
1

About The Author

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 4th, 2021

Last Reviewed: August 18th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.