Stem Cell Therapy for Brain Injury
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial is testing the safety and effects of infusing special stem cells (HB-adMSC) into adults with brain injuries. The goal is to see if these stem cells can help repair brain damage and reduce inflammation, potentially improving thinking and movement abilities. Researchers will look at changes in brain structure and function to determine the treatment's effectiveness.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the study team to understand any specific requirements.
Is stem cell therapy safe for brain injury treatment?
Research on fetal human neural stem cells (hNSCs) in rats with brain injuries showed no evidence of tumor formation, suggesting they are safe for transplantation. Additionally, human amniotic mesenchymal stem cells (hAMSCs) have been studied in rats and showed positive effects without safety concerns, indicating potential safety in humans.12345
How is the treatment HB-adMSCs for brain injury different from other treatments?
The treatment HB-adMSCs (human bone marrow-derived stem cells) is unique because it involves using stem cells to potentially repair brain damage by promoting the growth of new neurons (nerve cells) and supporting brain recovery, which is different from traditional treatments that may not directly target brain repair.56789
What data supports the effectiveness of the treatment HB-adMSCs for brain injury?
Who Is on the Research Team?
Charles S Cox, MD
Principal Investigator
The University of Texas Health Science Center, Houston
Are You a Good Fit for This Trial?
Adults aged 18-55 with traumatic brain injury or hypoxic-ischemic encephalopathy for over 6 months, who have a moderate to severe disability (GOS-E score >2 and ≤6), can consent, and speak English/Spanish. Excludes those with cancer, immune or bleeding disorders, severe lung disease, normal brain scans, certain heart valves/prosthetic issues, kidney/liver disease, HIV+, substance dependency or other conditions that may increase risk.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
HB-adMSCs will be infused three times over a six week period, spaced 14 days apart
Follow-up
Participants are monitored for safety and effectiveness after treatment, with evaluations at 6 months and 1 year post-infusion
What Are the Treatments Tested in This Trial?
Interventions
- HB-adMSCs
Find a Clinic Near You
Who Is Running the Clinical Trial?
Hope Biosciences
Lead Sponsor
The University of Texas Health Science Center, Houston
Collaborator